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“Discontinuous” Thioproperazine: A Controlled Trial in Chronic Schizophrenia

Published online by Cambridge University Press:  29 January 2018

J. Moffat  and
E. C. MacLeod
J. Moffat
Affiliation:
Glasgow Royal Mental Hospital
E. C. MacLeod
Affiliation:
Department of Psychological Medicine, Southern General Hospital, Glasgow
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Extract

It became apparent soon after the introduction of chlorpromazine and reserpine that these drugs were capable both of influencing psychoses and of producing neurological disturbances closely resembling those seen in post-encephalitic Parkinsonism. In classifying drugs with these effects as “neuroleptics” Delay et al. (2) indicated that they considered the two actions to be inseparable thus implying that both resulted from common or closely related neurophysiological changes. On this basis it seemed likely that drugs which more readily produced these neurological disturbances would prove more effective in psychotic illness. It also seemed possible that there might be therapeutic value in the deliberate provocation of such disturbances, as was first advocated by Fleugel (6). The theoretical issues involved were referred to in a previous paper (MacLeod and Moffat (8)).

Type
Research Article
Information
The British Journal of Psychiatry , Volume 110 , Issue 469 , November 1964 , pp. 851 - 854
Copyright
Copyright © Royal College of Psychiatrists, 1964 

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References

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