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Depression in people with first-episode schizophrenia

Published online by Cambridge University Press:  06 August 2018

Donald Addington*
Affiliation:
Department of Psychiatry, University of Calgary, Alberta, Canada
Jean Addington
Affiliation:
Department of Psychiatry, University of Calgary, Alberta, Canada
Scott Patten
Affiliation:
Department of Psychiatry, University of Calgary, Alberta, Canada
*
Correspondence: Donald Addington, Department of Psychiatry, University of Calgary, Foothills Hospital, 1403 29 Street NW Calgary, Alberta, Canada, T2N 2T9

Abstract

Background Depression has been described in people presenting with first-episode schizophrenia, a group at high relative risk of suicide.

Method This was a longitudinal cohort study of 113 people during an acute relapse and 13 having a first episode. Follow-up occurred at three months and at one year. This report compares level of depression in the first episode and in the relapsing group. Levels of depression were assessed using the Calgary Depression Scale for Schizophrenia (CDSS).

Results The median CDSS score was statistically significantly higher in the first-episode group both during the acute phase and at three month follow-up. At one year the first-episode group continued to have higher levels of depression than the multiple episode group.

Conclusions For people with a first episode of schizophrenia, depression is a major problem during the initial acute phase and during the first year of illness. In light of the high risk of suicide in this population, recognition and treatment of depression requires greater attention.

Type
Research Article
Copyright
Copyright © 1998 The Royal College of Psychiatrists 

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References

Addington, D., Addington, J. & Schissel, B. A. (1990) A depression rating scale for schizophrenics. Schizophrenia Research, 3, 247251.Google Scholar
Addington, D. & Addington, J. (1992) Attempted suicide and depression in schizophrenia. Acta Psychiatrica Scandinavica, 85, 288291.Google Scholar
Addington, D., Addington, J. & Maticka-Tyndale, E. (1992) Reliability and validity of a depression rating scale for schizophrenics. Schizophrenia Research, 6, 201208.Google Scholar
Addington, D., Addington, J. & Maticka-Tyndale, E. (1993) Assessing depression in schizophrenia: the Calgary Depression Scale. British Journal of Psychiatry, 163 (suppl. 22), 3944.Google Scholar
Addington, D., Addington, J. & Maticka-Tyndale, E. (1994) Specificity of the Calgary Depression Scale. Schizophrenia Research, II, 239244.Google Scholar
American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM–III–R). Washington, DC: APA.Google Scholar
American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM–IV). Washington, DC: APA.Google Scholar
Beck, A.T., Ward, C. H., Mendelson, M., et al (1961) An inventory for measuring depression. Archives of General Psychiatry, 4, 561571.CrossRefGoogle ScholarPubMed
Bromet, E. J., Schwartz, J. E., Fennig, S., et al (1992) The epidemiology of psychosis: the Suffolk County Mental Health Project. Schizophrenia bulletin, 18, 243255.Google Scholar
Bustamante, S., Maurer, K., Loffler, W., et al (1994) Depression in the early course of schizophrenia. Fortschritte der Neurologie-Psychiatrie, 62, 317329.Google Scholar
Gaffan, E. A., Tsaousis, I. & Kemp-Wheeler, S. M. (1995) Researcher allegiance and meta-analysis: the case of cognitive therapy for depression. Journal of Consulting and Clinical Psychology, 63, 966980.Google Scholar
Ganguli, R. & Brar, J. S. (1992) Generalizability of first-episode studies in schizophrenia. Schizophrenia Bulletin, 18, 463469.CrossRefGoogle ScholarPubMed
Gift, T. E., Strauss, J. S., Kokes, R. F., et al (1990) The temporal relationship between depressive and psychotic symptoms in recent-onset schizophrenia. American journal of Psychiatry, 147, 179182.Google Scholar
Hamilton, M. (1967) Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology, 6, 278296.Google Scholar
House, A., Bostock, J. & Cooper, J. E. (1987) Depressive syndromes in the first year following onset of a first schizophrenic illness. British Journal of Psychiatry, 151, 773779.Google Scholar
Jablensky, A., Sartorius, N., Ernberg, G., et al (1992) Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organization Ten Country Study. Psychological Medicine, Monograph suppl. 20, 195 Google Scholar
Jackson, H., McGorry, P., Edwards, J., et al (1998) Cognitively-oriented psychotherapy for early psychosis (COPE). Preliminary results. British Journal of Psychiatry, 172 (suppl. 33), 93100.CrossRefGoogle ScholarPubMed
Johnson, D. A.W. (1981) Studies of depressive symptoms in schizophrenia. I. The prevalence of depression and its possible causes. British Journal of Psychiatry, 139, 89101.Google Scholar
Johnstone, E. C., Crow, T. J., Johnson, A. L., et al (1986) The Northwick Park study of first-episode schizophrenia: Presentation of the illness and problems relating to admission. British Journal of Psychiatry, 148, 115120.Google Scholar
Kingdon, D., Turkington, D. & John, C. (1994) Cognitive behaviour therapy of schizophrenia. British Journal of Psychiatry, 164, 581587.Google Scholar
Koreen, A. R., Siris, S. G., Chakos, M., et al (1993) Depression in first-episode schizophrenia. American Journal of Psychiatry, 150, 16431648.Google ScholarPubMed
Montgomery, S. A. & Äsberg, M. (1979) A new depression scale designed to be sensitive to change. British Journal of Psychiatry, 134, 382389.Google Scholar
Mortensen, P. B. & Juel, K. (1993) Mortality and causes of death in first admitted schizophrenic patients. British Journal of Psychiatry, 163, 183189.CrossRefGoogle ScholarPubMed
Overall, J. E. & Gorham, D. R. (1962) The Brief Psychiatric Rating Scale. Psychological Reports, 10, 799812.Google Scholar
Perris, C. & Skagerlind, L. (1994) Cognitive therapy with schizophrenic patients. Acta Psychiatrica Scandinavica, suppl. 89, 6570.Google Scholar
Roy, A. (1986) Depression, attempted suicide, and suicide in patients with chronic schizophrenia. Psychiatric Clinics of North America, 9, 193206.Google Scholar
Ryan, B. F. & Joiner, B. L. (1994) Minitab Handbook (3rd edn). Belmont, CA: Duxberry Press.Google Scholar
Salokangas, R. K. R. & Stengard, E. (1990) Gender and short-term outcome in schizophrenia. Schizophrenia Research, 3, 333345.Google Scholar
Shepherd, M., Watt, D., Falloon, I., et al (1989) The natural history of schizophrenia: a five year follow-up study of outcome and prediction in a representative sample of schizophrenics. Psychological Medicine, Monograph suppl. 15, 146.Google Scholar
Shtasel, D. L., Gur, R. E., Gallacher, F., et al (1992) Phenomenology and functioning in first-episode schizophrenia. Schizophrenia Bulletin, 18, 449462.Google Scholar
Siris, S. G., Morgan, V., Fagerstrom, R., et al (1987) Adjunctive imipramine in the treatment of post psychotic depression. Archives of General Psychiatry, 44, 533539.Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1978) Research diagnostic criteria rationale and reliability. Archives of General Psychiatry, 35, 773782.CrossRefGoogle ScholarPubMed
Spitzer, R. L., Williams, J. B., Gibbon, M., et al (1992) The structured clinical interview for DSM–III–R (SCID) I: history, rationale, and description. Archives of General Psychiatry, 49, 624629.Google Scholar
Williams, J. B., Gibbon, M., First, M. B., et al (1992) The structured clinical interview for DSM–III–R (SCID) II: multisite test-retest reliability. Archives of General Psychiatry, 49, 630636.Google Scholar
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