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Depot Injections and Tardive Dyskinesia

Published online by Cambridge University Press:  29 January 2018

Alan C. Gibson
Alan C. Gibson*
Affiliation:
East Dorset Health Care District (St Ann's Hospital, Canford Cliffs, Poole, Dorset); Hon. Lecturer, University of Southampton
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Summary

A prospective study was undertaken on 374 out-patients receiving depot fluphenazine or depot flupenthixol to determine the incidence of tardive dyskinesia. In three years the percentage showing the bucco-linguo-masticatory syndrome rose from 8 per cent to 22 per cent, though patients had received various neuroleptics for a mean of 13 years previously. Fluphenazine and flupenthixol were equally involved though 75 per cent of affected patients had the condition in mild degree. Six additional cases of generalized chorea were all receiving flupenthixol. Reduction of dose or the substitution of pimozide produced marked improvement, but results suggest that it is unlikely that this will be permanent. Substitution of depot fluspirilene also produced favourable results. Careful monitoring, minimal neuroleptic dosage, and periods of neuroleptic abstinence are recommended.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 133 , Issue 4 , October 1978 , pp. 361 - 365
Copyright
Copyright © Royal College of Psychiatrists, 1978 

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