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Decreased Imipramine Binding in the Brains of Patients with Depressive Illness

Published online by Cambridge University Press:  29 January 2018

E. K. Perry ,
E. F. Marshall ,
G. Blessed ,
B. E. Tomlinson  and
R. H. Perry
E. K. Perry
Affiliation:
Department of Neuropathology, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE
E. F. Marshall
Affiliation:
Department of Psychiatry, University of Newcastle upon Tyne
G. Blessed
Affiliation:
University Department of Psychiatry, Brighton Clinic, Newcastle General Hospital
B. E. Tomlinson
Affiliation:
Department of Pathology, Newcastle General Hospital
R. H. Perry
Affiliation:
MRC Neuroendocrinology Unit, Newcastle General Hospital
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Summary

The binding of tritiated imipramine was significantly reduced in the hippocampus and occipital cortex from a series of patients with depressive illness compared with age-matched patients with no psychiatric disorder. In contrast there was no change in imipramine binding in established cases of senile dementia of Alzheimer-type. Scatchard analysis indicated normal binding affinity but a reduction in the number of imipramine binding sites in depression. These observations parallel previous findings of decreased binding sites in platelets from depressed patients and suggest there may be an abnormality in the uptake mechanism for serotonin in depression.

Type
Papers
Information
The British Journal of Psychiatry , Volume 142 , Issue 2 , February 1983 , pp. 188 - 192
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

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