Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-31T20:59:45.919Z Has data issue: false hasContentIssue false
  • English
  • Français

Cytogenetic Investigation in Twins with Manic-Depressive Disorders (22 Monozygotic and 27 Dizygotic Twin Pairs)

Published online by Cambridge University Press:  29 January 2018

Johannes Nielsen ,
Akira Homma  and
Aksel Bertelsen
Johannes Nielsen
Affiliation:
The Cytogenetic Laboratory and the Institute of Psychiatric Demography, Aarhus Psychiatric Hospital, Risskov, Denmark
Akira Homma
Affiliation:
The Cytogenetic Laboratory and the Institute of Psychiatric Demography, Aarhus Psychiatric Hospital, Risskov, Denmark
Aksel Bertelsen
Affiliation:
The Cytogenetic Laboratory and the Institute of Psychiatric Demography, Aarhus Psychiatric Hospital, Risskov, Denmark
Get access Rights & Permissions [Opens in a new window]

Summary

Chromosome examination was made in 22 monozygotic and 27 dizygotic twin pairs of whom one or both of each pair suffered or had suffered from manic-depressive disorder. We found a significantly higher frequency of chromosome variations among dizygotic twin pairs than was expected from population studies, but not in monozygotic pairs. There was no association between the chromosome variations and manic-depressive disorders. We found no greater intra-pair correlation in monozygotic twins compared with dizygotic twins as regards hypodiploidy, hyperdiploidy and unstable chromosome aberrations, which indicates that the aetiology of such aberrations is mainly of exogenic nature.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 130 , Issue 4 , April 1977 , pp. 352 - 354
Copyright
Copyright © Royal College of Psychiatrists, 1977 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bertelsen, A., Harvald, B. & Hauge, M. (1977) A Danish twin study of manic-depressive disorders. British Journal of Psychiatry. In press.Google Scholar
Bochkov, N. P., Kuleshov, N. P., Chebotarev, A. N., Alekhin, V. I. & Midian, S. A. (1974) Population cytogenetic investigation of newborns in Moscow. Humangenetik, 22, 139–52.CrossRefGoogle ScholarPubMed
Ebaugh, I. A., Freiman, M., Woolf, R. B., Sherman, A. I. & Winokur, G. (1968) Chromosome studies in patients with affective disorder (manic-depressive illness). Archives of General Psychiatry, 19, 751–2.Google Scholar
Hamerton, J. L., Canning, N., Ray, M. & Smith, S. (1975) A cytogenetic survey of 14,069 newborn infants. Incidence of chromosome abnormalities. Clinical Genetics, 8, 223–43.CrossRefGoogle Scholar
Homma, A. & Nielsen, J. Chromosome aneuploidy associated with aging. Neuropsychobiology. In press.Google Scholar
Jarvik, L. F. & Kato, T. (1970) Chromosome examinations in aged twins. The American Journal of Human Genetics, 22, 562–73.Google Scholar
Jarvik, L. F., Altschuler, K. Z., Kato, T. & Blumner, B. (1971) Organic brain syndrome and chromosome loss in aged twins. Diseases of the Nervous System, 32, 159–70.Google Scholar
Nielsen, J. (1968) Chromosomes in senile dementia. The British Journal of Psychiatry, 114, 303–9.Google Scholar
Nielsen, J. (1970) Chromosomes in senile, presenile, and arteriosclerotic dementia. Journal of Gerontology, 25, 312–15.Google Scholar
Nielsen, J. (1975) Chromosome examination of male patients in a psychiatric hospital. British Journal of Psychiatry, 127, 404–9.Google Scholar
Nielsen, J. & Sillesen, I. (1975) Incidence of chromosome aberrations among 11, 148 newborn children. Humangenetik, 30, 1–12.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.