Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-22T08:34:53.187Z Has data issue: false hasContentIssue false

Cytogenetic abnormalities on chromosome 18 associated with bipolar affective disorder or schizophrenia

Published online by Cambridge University Press:  03 January 2018

Ole Mors*
Affiliation:
Institute for Basic Psychiatric Research, Risskov, Denmark
Henrik Ewald
Affiliation:
Institute for Basic Psychiatric Research, Risskov, Denmark
Douglas Blackwood
Affiliation:
Edinburgh University Department of Psychiatry, and MRC Human Genetics Unit, The Royal Edinburgh, Morningside Park, Edinburgh EH10 5HF
Walter Muir
Affiliation:
Edinburgh University Department of Psychiatry, and MRC Human Genetics Unit, The Royal Edinburgh, Morningside Park, Edinburgh EH10 5HF
*
Dr Ole Mors, Institute for Basic Psychiatric Research, Department of Psychiatric Demography, Skovagervej 2, DK-8240 Risskov, Denmark. Fax: +86 177455

Abstract

Background

A few recent linkage studies have shown a possible locus for bipolar disorder on chromosome 18. Cytogenetic studies may assist in the further localisation of susceptibility loci on this chromosome.

Method

A search was made for abnormalities of chromosome 18 in two separate large cytogenetic databases. In Denmark detection of mental illness in subjects with chromosome abnormalities was done by cross-linking the two separate register of psychiatric and chromosome disorders. In Scotland the Cytogenetic Registry of the MRC Human Genetics Unit undertakes long-term clinical follow-up of all cases with chromosome abnormalities.

Results

Cross-linking the two Danish register's revealed a family with the rare karyotype abnormality inv(18) (p11.3;q21.1) with one inversion carrier who also suffered from bipolar disorder. In this family there were two other cases of bipolar disorder, but the karyotype of these cases could not be established. One family in Scotland showed a case of schizophrenia in a carrier of inv(18) with the same breakpoints as the Danish family.

Conclusions

We suggest further studies of the 18p11.3 and 18q21.1 regions in order to identify genes involved in bipolar affective disorder and schizophrenia.

Type
Papers
Copyright
Copyright © 1997 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association (1996) Diagnostic ond Statistical Manual of Mental Disorders (4th edn) (DSM-IV). Washington, DC: APA.Google Scholar
Berrettini, W H., Ferraro, T. N., Goldin, L. R., et al (1994) Chromosome 18 DNA markers and manic-depressive illness: Evidence for a susceptibility gene. Proceedings of the National Academy of Science of the United States of America. 91, 59185921.Google Scholar
Berrettini, W H., Ferraro, T. N., Goldin, L. R., et al (1997) A linkage study of bipolar illness. Archives of General Psychiatry, in press.Google Scholar
Calzolari, E., Alello, V., Palazzi, P., et al (1994) Psychiatric disorder in familial 15; 18 transkxation and subfocalization of myelin basic protein to 18q22.3. American Journal of Medical Genetics (Neuropsychiatric Genetics). 47, 154161.Google Scholar
Coon, H., Jonson, S., Holik, J., et al (1994) Genomic scan for genes predisposing to schizophrenia. American Journal of Medical Genetics (Neuropsychiatrie Genetics). 54, 5971.Google Scholar
Coon, H., Jonson, S., Hoff, M., Holik, J., et al (1994) Analysis of chromosome 18 DNA markers in multiplex pedigrees with manic depression. Biological Psychiatry, 39, 689696.Google Scholar
Do Bruyn, A., Souary, D., Mandalbaum, K., et al (1994) Linkage analysis of families with bipolar illness and chromosome 18 markers. Biological Psychiatry 39, 679688.Google Scholar
Dalisi, L., Lofthousa, R., Lahner, T., et al (1995) Failure to find a chromosome 18 pericentric linkage in families with schizophrenia. American Journal of Medical Genetics (Neuropsychiatric Genetics). 40, 532534.Google Scholar
Ewald, H., Mors, O., Kood, K., et al (1997) Susceptibility loci for bipolar affective disorder on chromosome 18? A review and a study of Danish families. Psychiatric Genetics, in press.Google Scholar
Freimer, N. B., Raus, V. I., Escamilla, M. A., et al (1994) Genetic mapping using hapkrtype. association and linkage nncthods suggests a locus for severe bipolar disorder (BP1) at 18q22-q23. Nature Genetics. 12, 436441.Google Scholar
Garshon, E. S. & Cloninger, C. R. (1994) Genetic Approaches to Mental Disorders, pp. 149192. Washington. DC: American Psychiatric Press.Google Scholar
Kandall, R. E. (1987) Diagnosis and classification of functional psychoses. British Medical Bulletin, 431, 499513.CrossRefGoogle Scholar
Krag-Olsan, B., Brask, B. H., Jacobson, P., et al (1981) Is there an increased risk of psychoses in patients with ring 18 and deletion king arm 18? In Human Behaviour and Genetics (eds Schmid, W. & Nielsen, J.), pp. 211220. Amsterdam: Elsevier/North-Holland Biomedical Press.Google Scholar
Mahr, R. N., Moberg, P. J., Ovarhausar, J., et al (1994) Neuropsychiatry of 18q-syndronne. American Journal of Medical Genetics (Neuropsychiatric Genetics), 47, 172178.Google Scholar
Malar, W., Hallmayar, J., Zill, P., et al (1995) Linkage analysis between pericentrometric markers on chromosome 18 and bipolar disorders: A replication test. Psychiatry Research, 59, 715.Google Scholar
Manuzza, S., Pyar, A., Klain, D. et al (1984) Schedule for affective disorders and schizophrenia – lifetime version modified for the study of anxiety disorders (SADS-LA). Rationale and conceptual development. Journal of Psychiatric Research, 20, 317325.Google Scholar
Mazlada, M., Dabraajakaar, M., Ganest, P., et al (1993) A balanced 2:18 translocation and familial schizophrenia: Falling short of an association. Archives of General Psychiatry, 50, 7373.Google Scholar
McGuffin, P., Farmar, A. & Harvay, I. (1991) A polydiagnostic application of operational criteria in studies of psychotic illness. Archives of General Psychiatry, 40, 764770.Google Scholar
Moises, H. W., Yang, L., Kristbjarnarson, H., et al (1995) An international two-stage genome-wide search for schizophrenia susceptibility genes. Nature Genetics. 11, 321324.Google Scholar
Munk-Jorgensen, P., Kastrup, M. & Mortansen, P. B. (1993) The Danish psychiatric register as a tool in epidemiology Acta Psychiatrica Scandinavica. Suppl. 370. 27 32.Google Scholar
Nialsan, J. (1900) The Danish Cytogenetk Central Register: Organization and results. In Topics in Human Genetics, vol. V (eds Becker, P. E., Lenz, W., Vogel, F., et al). New York: Georg Thieme Verlag Stuttgart.Google Scholar
Pauls, D. L., Ott, J., Paul, S. M., et al (1995) Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the Old Order Amish. American Journal of Human Genetics, 57, 636643.Google Scholar
St Clair, D., Blackwood, D., Mulr, W., et al (1909) No linkage to chromosome 5q11-q13 markers to schizophrenia in Scottish families. Nature. 339, 305309.CrossRefGoogle Scholar
Stine, O. C., Xu, J., Koskala, R., et al (1995) Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. American Journal of Human Genetics, 57, 13841394.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.