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Correlations Between Akathisia and Residual Psychopathology: A By-product of Neuroleptic-Induced Dysphoria

Published online by Cambridge University Press:  02 January 2018

John W. Newcomer ,
L. Stephen Miller ,
William O. Faustman ,
Martin W. Wetzel ,
George P. Vogler  and
John G. Csernansky
John W. Newcomer*
Affiliation:
Department of Psychiatry, Washington University School of Medicine, 4940 Children's Place, St Louis, Missouri 63110, USA
L. Stephen Miller
Affiliation:
Department of Psychology, University of Georgia, Athens GA
William O. Faustman
Affiliation:
Department of Veteran Affairs Medical Center, Palo Alto, CA, and the Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Stanford, CA
Martin W. Wetzel
Affiliation:
Department of Psychiatry, Washington University School of Medicine
George P. Vogler
Affiliation:
Department of Biostatistics, Washington University School of Medicine
John G. Csernansky
Affiliation:
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
*
∗Correspondence
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Abstract

Patients developing neuroleptic-induced akathisia have been reported to show higher levels of psychopathology. We sought to replicate this finding and determine its symptom specificity. We confirmed a significant relationship between ratings of akathisia and total score on the Brief Psychiatric Rating Scale (BPRS) during both acute and maintenance neuroleptic treatment. Using stepwise regression models, BPRS anxious-depressive subscale scores were the strongest predictors of akathisia during both treatment conditions. Paranoid subscale scores predicted akathisia only during maintenance treatment. These results suggest that neuroleptic-induced dysphoria largely explains the relationship between akathisia and residual psychopathology during both acute and maintenance neuroleptic treatment.

Type
Short papers
Information
The British Journal of Psychiatry , Volume 164 , Issue 6 , June 1994 , pp. 834 - 838
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

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