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A Controlled Trial of Phenothiazine Withdrawal in Chronic Schizophrenic Patients

Published online by Cambridge University Press:  29 January 2018

P. Andrews ,
J. N. Hall  and
R. P. Snaith
P. Andrews
Affiliation:
Stanley Royd Hospital, Wakefield, Yorkshire
J. N. Hall
Affiliation:
Stanley Royd Hospital, Wakefield, Yorkshire
R. P. Snaith
Affiliation:
Stanley Royd Hospital, Wakefield, Yorkshire
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Summary

Phenothiazine drugs were withdrawn from 17 chronic schizophrenic in-patients, with a control group of 14 patients remaining on active medication. The trial was conducted under double blind conditions over a period of 42 weeks with weekly assessment of the patients by ward nurses. Of the placebo group 35 per cent relapsed, relapse being related to the level of previous active medication.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 128 , Issue 5 , May 1976 , pp. 451 - 455
Copyright
Copyright © Royal College of Psychiatrists, 1976 

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References

Cafffey, E. M., Diamond, L. S., Frank, T. V., Grasberger, J. C., Herman, L., Klett, G. J. & Rothstein, C. (1964) Discontinuation or reduction of chemotherapy in chronic schizophrenia. Journal of Chronic Diseases, 17, 347–58.Google Scholar
Cooper, J. E., Kendell, R. E., Gurland, B. J., Sharpe, L., Copeland, J. R. M. & Simon, R. (1972) Psychiatric Diagnosis in New York and London. Maudsley Monograph No 20, Oxford University Press.Google Scholar
Good, W. W., Sterling, M. & Holzman, W. H. (1958) Termination of chlorpromazine with schizophrenic patients. American Journal of Psychiatry, 115, 443–8.Google Scholar
Hughes, J. S. & Little, J. C. (1967) An appraisal of the continuing practice of prescribing tranquillizing drugs for long-stay psychiatric patients. British Journal of Psychiatry, 113, 867–73.Google Scholar
Prien, R. F., Cole, J. O. & Belkin, N. F. (1968) Relapse in chronic schizophrenics following abrupt withdrawal of tranquillizing medication. British Journal of Psychiatry, 115, 679–86.Google Scholar
Prien, R. F., & Klett, C. J. (1970) An Appraisal of the Longterm Use of Tranquillizing Medication with Hospitalized Chronic Schizophrenics . Pre-publication Report No 85, Central Neuropsychiatrie Research Laboratory. Perry Point, Maryland.Google Scholar
Rathod, N. H. (1958) Tranquillizers and patients' environment. Lancet, i, 611–13.Google Scholar
Tobias, L. L. & MacDohald, M. L. (1974) Withdrawal of maintenance drugs with long-term hospitalized mental patients: a critical review. Psychological Bulletin, 81, 107–23.Google Scholar
Wing, J. K. (1961) A simple and reliable subclassification of chronic schizophrenia. Journal of Mental Science, 107, 862–75.Google Scholar
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