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Clomipramine versus Phenelzine in Obsessive–Compulsive Disorder

A Controlled Clinical Trial

Published online by Cambridge University Press:  02 January 2018

J. Vallejo ,
J. Olivares ,
T. Marcos ,
A. Bulbena  and
J. M. Menchón
J. Vallejo*
Affiliation:
Hospital de Prínceps d'Espanya
J. Olivares
Affiliation:
Hospital Clinic i Provincial, Barcelona
T. Marcos
Affiliation:
Department of Psychiatry, Hospital Clínic i Provincial, Barcelona
A. Bulbena
Affiliation:
Hospital del Mar, Barcelona, and Professor of Psychiatry, University of País Vasco, Barcelona
J. M. Menchón
Affiliation:
Hospital de Prínceps d'Espanya, Ciutat Sanitaria i Universitària de Bellvitge, Barcelona, Spain
*
∗Hospital de Bellvitge, Servicio de Psiquiatria, Feixa Llarga s/n, 08907 Hospitalet de Llobregat (Barcelona), Spain
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Abstract

A double-blind clinical trial of clomipramine versus phenelzine was carried out on 30 patients suffering from DSM–III obsessive–compulsive disorder. The study period was 12 weeks, and the maximum doses used (from the fifth week on) were 225 mg/day for clomipramine (14 patients) and 75 mg/day for phenelzine (12 patients); four patients dropped out. Obsessive symptoms improved significantly in both drug groups, but there was no significant difference between groups. Depressive symptoms improved before obsessive ones.

Type
Papers
Information
The British Journal of Psychiatry , Volume 161 , Issue 5 , November 1992 , pp. 665 - 670
Copyright
Copyright © 1992 The Royal College of Psychiatrists 

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