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Clinical use of the DST in a Psychogeriatric Population

Published online by Cambridge University Press:  29 January 2018

Ian G. McKeith
Ian G. McKeith*
Affiliation:
Brighton Clinic, Newcastle General Hospital
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Summary

The dexamethasone suppression test (DST) was administered to 95 patients referred to a psychogeriatric assessment service. Non-suppression of plasma cortisol was found in 28 out of 48 patients (58%) with senile dementia and all patients with arteriosclerotic dementia or acute confusional states. Non-suppression could not be explained by associated depressive symptoms. The DST was confirmed as a valid diagnostic test for endogenous depression in the elderly, but its value in distinguishing true dementing illnesses from depressive pseudodementia was not supported. The clinical implications of these findings for interpreting DST results in the elderly are discussed.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 145 , Issue 4 , October 1984 , pp. 389 - 393
Copyright
Copyright © 1984 The Royal College of Psychiatrists 

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References

Balldin, J., Gottfries, C. G., Karlsson, I., Lindstedt, G., Langstrom, G. & Walinder, J. (1983) D.S.T. and serum prolactin in dementia. British Journal of Psychiatry, 143, 277–81.CrossRefGoogle Scholar
Blessed, G., Tomlinson, B. E. & Roth, M. (1968) The association between quantitive measures of dementia and of senile change in the cerebral grey matter of elderly subjects. British Journal of Psychiatry, 114, 797–811.CrossRefGoogle ScholarPubMed
Carney, M. W. P., Roth, M. & Garside, R. F. (1965) The diagnosis of depressive syndromes and the prediction of ECT response. British Journal of Psychiatry, 111, 659–74.CrossRefGoogle Scholar
Carroll, B. J., Feinberg, M., Greden, J. F., Tarika, J., Albala, A., Haskett, R. F., McIJames, N., Kronfol, Z., Lohr, N., Steiner, M., de Vigne, J. P. & Young, E. (1981) A specific laboratory test for the diagnosis of melancholia. Standardization, validation and clinical utility. Archives of General Psychiatry. 38, 15–22.CrossRefGoogle ScholarPubMed
Coppen, A., Abou-Saleh, M., Millin, P., Metcalfe, M., Harwood, J. & Bailey, J. (1983) Dexamethasone suppression in depression and other psychiatric illness. British Journal of Psychiatry. 142, 498–504.CrossRefGoogle ScholarPubMed
Feinberg, M. & Carroll, B. J. (1982) Separation of subtypes of depression using discriminant analysis. British Journal of Psychiatry, 140, 384–91.CrossRefGoogle ScholarPubMed
Hällström, T., Samuelsson, S., Balldin, J., Wålinder, J., Bengtsonn, C., Nystrom, E., Andersch, B., Lindstedt, G. & Lundberg, P. A. (1983) Abnormal dexamethasone suppression in normal females. British Journal of Psychiatry, 142, 489–97.CrossRefGoogle ScholarPubMed
Lipsey, J. R., Robinson, R. G., Pearlson, G. D., Rao, K. & Price, T. R. (1983) Mood change following bilateral hemisphere brain injury. British Journal of Psychiatry. 143, 266–73.CrossRefGoogle ScholarPubMed
McAllister, T. W., Ferrell, R. B., Price, T. R. P. & Neville, M. B. (1982) The dexamethasone suppression test in two patients with severe depressive pseudodementia. American Journal of Psychiatry. 139, 479–81.Google ScholarPubMed
Nelson, W. M. (1982) Effect of age on DST results (Letter) American Journal of Psychiatry, 139, 1376.Google Scholar
Raskind, M., Peskind, E., Rivard, M. F., Veith, R. & Barnes, R. (1982) Dexamethasone suppression test and cortisol rythm in primary degenerative dementia. American Journal of Psychiatry, 139, 1468–71.Google Scholar
Robinson, R. G. & Szetela, B. (1981) Mood change following left hemispheric injury. Annals of Neurology, 9, 447–53.CrossRefGoogle Scholar
Roth, M. (1955) The natural history of mental disorders in the senium. Journal of Mental Science, 101, 281–301.CrossRefGoogle Scholar
Rudörfer, M. V. & Clayton, P. J. (1982) Pseudodementia — use of the DST in diagnosis and treatment monitoring. Psychosomatics, 23, 429–31.CrossRefGoogle ScholarPubMed
Spar, J. E. & Gerner, R. (1982) Does the dexamethasone suppression test distinguish dementia from depression? American Journal of Psychiatry, 139, 238–40.Google ScholarPubMed
Spar, J. E. & Gerner, R. & La Rue, A. (1983) Major depression in the elderly, DSM III criteria and the DST as predictors of treatment response. American Journal of Psychiatry, 140, 844–7.Google Scholar
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