Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-25T19:08:52.760Z Has data issue: false hasContentIssue false
  • English
  • Français

Clinical Trial of Mebanazine—A New Monoamine Oxidase Inhibitor

Published online by Cambridge University Press:  29 January 2018

S. J. G. Gilmour
S. J. G. Gilmour*
Affiliation:
Tyrone and Fermanagh Hospital, Omagh, N. Ireland
Get access Rights & Permissions [Opens in a new window]

Extract

At the time when this investigation was being considered (June, 1961) the efficacy of the monoamine oxidase inhibitors in the treatment of depressive illnesses was already well recognized. It was also evident from a study of the published papers on this group of drugs that their use was accompanied by a number of side-effects which often raised problems in treatment. The clinical trial of a new drug of this class which, from the pre-clinical toxicity studies in animals, held promise of being less toxic than M.A.O. inhibitors already in clinical use was therefore considered worth while. Such a trial also seemed a useful opportunity to follow up previous observations with phenelzine (Gilmour, 1960) and the suggestion of Sargant (1961) that, given concurrently, M.A.O. inhibitors may potentiate the effect of E.C.T. and reduce the number of exposures necessary, and that their continuance after a course of E.C.T. has been completed may reduce the relapse rate.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 111 , Issue 478 , September 1965 , pp. 899 - 902
Copyright
Copyright © Royal College of Psychiatrists, 1965 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Crowther, A. F., Spines, A., and Young, E. H. P. (1962). Int. J. Neuropharmacol., 1, 141–144.Google Scholar
Gilmour, S. J. G. (1960). Brit. med. J., i, 503.Google Scholar
Horne, P. M., and Forrest, A. D. (1962). Scot. med. J., 7, 224–229.Google Scholar
Sargant, W. (1961). Brit. med. J., i, 225–227.Google Scholar
Spinks, A., and Young, E. H. P. (1963). Proceedings of the First International Pharmacological Meeting, Vol. 7, 303–311. Oxford: Pergamon Press.Google Scholar
Spinks, A., and Young, E. H. P. (1963). Personal communication.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.