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Cerebrospinal Fluid Vasopressin—Changes in Depression

Published online by Cambridge University Press:  29 January 2018

Annette Gjerris ,
Per Vendsborg ,
Mogens Hammer ,
Niels Juel Christensen  and
Ole J. Rafaelsen
Annette Gjerris
Affiliation:
University Department of Psychiatry, Rigshospitalet, 9 Blegdamsvej, 2100-DK Copenhagen, Denmark
Per Vendsborg
Affiliation:
Sct. Hans Hospital, Roskilde
Mogens Hammer
Affiliation:
University Department of Medicine, Rigshospitalet, Copenhagen
Niels Juel Christensen
Affiliation:
University Department of Medicine, Herlev Hospital, Copenhagen
Ole J. Rafaelsen
Affiliation:
Rigshospitalet, Copenhagen
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Abstract

Cerebrospinal flud (CSF), thyrotropin releasing hormone (TRH), CSF-vasopressin (AVP), plasma-AVP, CSF-osmolality, plasma-osmolality, CSF-adrenaline (A) and -noradrenaline (NA) were measured in psychiatric patients and controls. Psychiatric patients were classified according to ICD-9 and grouped into endogenous depression, non-endogenous depression, mania and schizophrenia. The depressive groups were classified according to the Newcastle Rating Scale for Depression 1965. Severity of disease was quantified by BRMES, BRMS and BPRS. No difference in CSF-TRH levels was seen among the different diagnostic groups and controls. A positive correlation between CSF-TRH and CSF-A was demonstrated. CSF-AVP concentrations were significantly lowered in both endogenous and non-endogenous depression; no correlation with CSF-A or -NA was seen. Neither did any difference between plasma levels of AVP, plasma-osmolality or CSF-osmolality appear among the groups investigated.

Type
Papers
Information
The British Journal of Psychiatry , Volume 147 , Issue 6 , December 1985 , pp. 696 - 701
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

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