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Brain White-Matter Lesions and Psychosis

Published online by Cambridge University Press:  02 January 2018

Bruce L. Miller ,
Ira M. Lesser ,
Kyle Boone ,
Mark Goldberg ,
Elizabeth Hill ,
Milton H. Miller ,
D. Frank Benson  and
Mark Mehringer
Bruce L. Miller*
Affiliation:
Department of Neurology
Ira M. Lesser
Affiliation:
Department of Psychiatry
Kyle Boone
Affiliation:
Department of Psychiatry
Mark Goldberg
Affiliation:
Department of Neurology
Elizabeth Hill
Affiliation:
Department of Psychiatry
Milton H. Miller
Affiliation:
Department of Psychiatry
D. Frank Benson
Affiliation:
Department of Radiology at Harbor-UCLA Medical Center
Mark Mehringer
Affiliation:
Department of Radiology at Harbor-UCLA Medical Center
*
∗Harbor-UCLA Medical Center, 1000 W. Carson, Torrance, CA 90509, USA.
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Abstract

In a prospective study of late-life onset psychosis, five of the first 27 patients studied had extensive white-matter lesions demonstrated by MRI and/or CT. None of 60 age-matched psychiatrically healthy controls demonstrated such lesions. All five patients had a mild dementia and a frontal behavioural syndrome. In addition, every patient performed poorly on neuropsychological tests of frontal function. Dysfunction of the frontal cortex associated with white-matter lesions appears to contribute to the clinical picture of some cases of late-life psychosis.

Type
Papers
Information
The British Journal of Psychiatry , Volume 155 , Issue 1 , July 1989 , pp. 73 - 78
Copyright
Copyright © The Royal College of Psychiatrists 

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