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Brain Damage in Diabetes Mellitus

Published online by Cambridge University Press:  29 January 2018

R. N. Bale*
Affiliation:
St. James' Hospital, Portsmouth, PO4 8LD; Department of Clinical Psychiatry, The United Birmingham Hospitals, The General Hospital, Steelhouse Lane, Birmingham, 4

Extract

Several previous studies have demonstrated involvement of the central nervous system in diabetes mellitus. Reske-Nielsen and Lundbaek (1963) gave a description of cerebral changes seen in an autopsy study of three cases of long term diabetes and considered these to contribute a diabetic encephalopathy. Lawrence et al. (1942) demonstrated lesions in the brain following fatal hypoglycaemia, and Fineberg and Altschul (1952) described cases in which permanent brain damage followed non-fatal hypoglycaemia. Grunnet (1963) found cerebral atherosclerosis to develop at an earlier age and more severely in the diabetic than the non-diabetic, and a higher incidence of cerebrovascular accident was found in diabetic than non-diabetic subjects by Alex et al. (1962).

Type
Research Article
Copyright
Copyright © Royal College of Psychiatrists, 1973 

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References

Alex, M., Baron, Esther, Goldenberg, G., and Blunenthal, H. T. (1962). ‘An autopsy study of cerebrovascular accident in diabetes mellitus.’ Circulation, 25, 663–73.Google Scholar
Brierly, J. B. (1961). ‘Clinico-pathological correlations in amnesia.’ Gerontologia clin., 3, 97109.Google Scholar
Fineberg, S. K., and Altschul, A. (1952). ‘The encephalopathy of hyperinsulinism.’ Ann. intern. Med., 36, 536–50.Google Scholar
Grunnet, Margaret (1963). ‘Cerebrovascular disease; diabetes and cerebral atherosclerosis.’ Neurology, 13, 486–91.CrossRefGoogle ScholarPubMed
Kendrick, D. C., Parboosingh, Rose-Cecile and Post, F. (1965). ‘A Synonym Learning Test for use with elderly psychiatric subjects: a validation study.’ Brit. J. soc. clin. Psychol., 4, 6371.CrossRefGoogle ScholarPubMed
Lawrence, R. D., Meyer, A., and Nevtn, S. (1942). ‘The pathological changes in the brain in fatal hypoglycaemia.’ Quart. J. Med., 35, 181201.Google Scholar
Malins, J. (1968a). ‘Management of diabetes’, in Clinical Diabetes Mellitus. Eyre and Spottiswoode.Google Scholar
Malins, J. (1968b). ‘Hypoglycaemia’, in Clinical Diabetes Mellitus. Eyre and Spottiswoode.Google Scholar
Marks, V., and Rose, C. (1965). ‘Morbid anatomy of the brain in hypoglycaemia’, in Hypoglycaemia. Blackwell.Google Scholar
Reske-Nielsen, Edith, and Lundbaek, K. (1963). ‘Diabetic encephalopathy; diffuse and focal lesions of the brain in long-term diabetes.’ Acta neurol. Scand., 39, Supp. 4, 273–90.Google Scholar
Walton, D., and Black, D. A. (1957). ‘The validity of a psychological test of brain damage.’ Brit. J. med. Psychol., 30, 270–9.Google Scholar
Walton, D., and Black, D. A.(1959). The predictive validity of a psychological test of brain damage.’ J. ment. Sci., 105, 807–10.Google Scholar
Wechsler, D. (1955). Manual for the Wechsler Adult Intelligence Scale. New York: The Psychological Corporation.Google Scholar
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