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Biological Determinants of Difficult to Treat Patients with Schizophrenia

Published online by Cambridge University Press:  06 August 2018

Tonmoy Sharma*
Affiliation:
Institute of Psychiatry
Robert Kerwin
Affiliation:
Institute of Psychiatry
*
Dr T. Sharma, Institute of Psychiatry, London SE5 8AF

Extract

Numerous studies have attempted to relate brain morphology to treatment outcome in schizophrenia in an attempt to define subtypes of schizophrenia that may respond well to antipsychotic treatment (Brown & Herz, 1989). This has potential clinical significance since, if we can predict outcome based on brain structure, it would then influence treatment.

Type
Research Article
Copyright
Copyright © 1996 The Royal College of Psychiatrists 

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References

Baldessarini, R. J., Cohen, B. D. & Tercher, M. H. (1988) Significance of neuroleptic dose and plasma level in the pharmacological treatment of psychoses. Archives of General Psychiatry, 45, 7991.Google Scholar
Bilder, R. M., Wu, H., Chakos, M. H., et al (1994) Cerebral morphometry and clozapine treatment in schizophrenia. Journal of Clinical Psychiatry, 55 (Suppl. B), 5356.Google Scholar
Bogerts, B., Ashtari, M., Degreef, G., et al (1990) Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia. Psychiatry Research, 35, 113.CrossRefGoogle ScholarPubMed
Bogerts, B., Falkai, P. & Greve, B. (1991) Evidence of reduced temporolimbic structure volumes in schizophrenia [letter; comment]. Archives of General Psychiatry, 48, 956958.Google Scholar
Bogerts, B., Lieberman, J. A., Ashtari, M., et al (1993) Hippocampus-amygdala volumes and psychopathology in chronic schizophrenia. Biological Psychiatry, 33, 236246.CrossRefGoogle ScholarPubMed
Boronow, J., Pickar, D., Ninan, P. T., et al (1985) Atrophy limited to the third ventricle in chronic schizophrenic patients. Report of a controlled series. Archives of General Psychiatry, 42, 266271.Google Scholar
Breier, A., Buchanan, R. W., Elkashef, A., et al (1992) Brain morphology and schizophrenia. A magnetic resonance imaging study of limbic, prefrontal cortex, and caudate structures. Archives of General Psychiatry, 49, 921926.CrossRefGoogle ScholarPubMed
Brown, W. A. & Herz, L. R. (1989) Response to neuroleptic drugs as a device for classifying schizophrenia. Schizophrenia Bulletin, 15, 123129.CrossRefGoogle ScholarPubMed
Cazzullo, C. L. (1963) Biological and clinical studies on schizophrenia related to pharmacological treatment. Recent Advances in Biological Psychiatry, 5, 114143.Google Scholar
Coppens, H., Sloof, C. J., Paans, M. C., et al (1991) High central D2 dopamine receptor occupancy as assessed with positron emission tomography in medicated but therapy resistant patients. Biological Psychiatry, 29, 629634.Google Scholar
Curtis, V. A. & Kerwin, R. W. (1995) Evidence for a role for serotonin in schizophrenia – implications for pharmacological management. Journal of Serotonin Research, 2, 17.Google Scholar
DeLisi, L. E., Hoff, A. L., Kushner, M., et al (1992) Left ventricular enlargement associated with diagnostic outcome of schizophreniform disorder. Biological Psychiatry, 32, 199201.CrossRefGoogle ScholarPubMed
Friedman, L., Knutson, L., Shurell, M., et al (1991) Prefrontal sulcal prominence is inversely related to response to clozapine in schizophrenia. Biological Psychiatry, 29, 865877.CrossRefGoogle ScholarPubMed
Friedman, L., Lys, C. & Schulz, S. C. (1992) The relationship of structural brain imaging parameters to antipsychotic treatment response: a review. Journal of Psychiatry and Neuroscience, 17, 4254.Google ScholarPubMed
Honer, W., Smith, G. N., Lapointe, J. S., et al (1995) Regional cortical anatomy and clozapine response in refractory schizophrenia. Neuropsychopharmacology, 13, 8587.Google Scholar
Grodzicki, J., Pardo, M., Schued, C., et al (1990) Differences in 3H spiperone binding to peripheral blood lymphocytes from neuroleptic responsive and non-responsive patients. Biological Psychiatry, 27, 13271330.CrossRefGoogle Scholar
Jeste, D. V., Kleinman, J. E., Potkin, S. G., et al (1982) Ex uno multi: subtyping the schizophrenic syndrome. Biological Psychiatry, 17, 199222.Google Scholar
Jewart, R. D., Lewine, R. R. J., Manning, D. E., et al (1991) Brain MRI abnormalities associated with reduced antipsychotic response to clozapine. Pp. 44A. New Orleans, Louisiana: Society of Biological Psychiatry.Google Scholar
Johnstone, E. C., Crow, T. J., Frith, C. D., et al (1976) Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet, ii, 924926.Google Scholar
Kaiya, H., Uematsu, M., Ofuji, M., et al (1989) Computerised tomography in schizophrenia. Familial versus non-familial forms of illness. British Journal of Psychiatry, 155, 444450.CrossRefGoogle ScholarPubMed
Kolakowska, T., Williams, A. O., Ardern, M., et al (1985) Schizophrenics with good and poor outcome. I. Early clinical features, response to neuroleptics and signs of organic dysfunction. British Journal of Psychiatry, 146, 229234.Google Scholar
Lieberman, J., Bogerts, B, Degreef, G., et al (1992) Qualitative assessment of brain morphology in acute and chronic schizophrenia. American Journal of Psychiatry, 149, 784794.Google Scholar
Lieberman, J., Jody, D., Geisler, S., et al (1993a) Time course and biologic correlates of treatment response in first-episode schizophrenia. Archives of General Psychiatry, 50, 369376.Google Scholar
Lieberman, J., Jody, D., Alvir, J. M., et al (19936) Brain morphology, dopamine, and eye-tracking abnormalities in first-episode schizophrenia. Prevalence and clinical correlates. Archives of General Psychiatry, 50, 357368.Google Scholar
Luchins, D. J. & Meltzer, H. Y. (1983) A blind, controlled study of occipital cerebral asymmetry in schizophrenia. Psychiatry Research, 10, 8795.Google Scholar
Luchins, D. J., Lewine, R. R. & Meltzer, H. Y. (1984) Lateral ventricular size, psychopathology, and medication response in the psychoses. Biological Psychiatry, 19, 2944.Google Scholar
MacDonald, H. L. & Best, J. J. (1989) The Scottish First Episode Schizophrenia Study. VI. Computerised tomography brain scans in patients and controls. British Journal of Psychiatry, 154, 492498.Google Scholar
Naber, D., Albus, M., Burke, H., et al (1985) Neuroleptic withdrawal in chronic schizophrenia: CT and endocrine variables relating to psychopathology. Psychiatry Research, 16, 207219.Google Scholar
Nasrallah, H. A., Kuperman, S., Hamra, B. J., et al (1983) Clinical differences between schizophrenic patients with and without large cerebral ventricles. Journal of Clinical Psychiatry, 44, 407409.Google Scholar
Nimgaonkar, V. L., Wessely, S., Tune, L. E., et al (1988) Response to drugs in schizophrenia: the influence of family history, obstetric complications and ventricular enlargement. Psychological Medicine, 18, 583592.Google Scholar
Pandurangi, A. K., Goldberg, S. C., Brink, D. D., et al (1989) Amphetamine challenge test, response to treatment, and lateral ventricle size in schizophrenia. Biological Psychiatry, 25, 207214.Google Scholar
Pilowsky, L. S., Costa, D. C., Ell, P. J., et al (1993) Antipsychotic medication, D2 dopamine receptor blockade and clinical response to 123I-IBZM SPET (Single Photon Emission Tomography) study. Psychological Medicine, 23, 791797.CrossRefGoogle ScholarPubMed
Schulz, S. C., Sinicrope, P., Kishore, P., et al (1983) Treatment response and ventricular brain enlargement in young schizophrenic patients. Psychopharmacology Bulletin, 19, 510512.Google Scholar
Smith, R. C., Largen, J., Calderon, M., et al (1983) CT scans and neuropsychological tests as predictors of clinical response in schizophrenics. Psychopharmacology Bulletin, 19, 505509.Google Scholar
Smith, R. C., Baumgartner, R., Ravichandran, G. K., et al (1985) Lateral ventricular enlargement and clinical response in schizophrenia. Psychiatry Research, 14, 241253.Google Scholar
Smith, R. C., Baumgartner, R., Ravichandran, G. K., et al (1987) Cortical atrophy and white matter density in the brains of schizophrenics and clinical response to neuroleptics. Acta Psychiatrica Scandinavica, 75, 1119.Google Scholar
Uematsu, M. & Kaiya, H. (1988) Cerebellar vermal size predicts drug response in schizophrenic patients: a magnetic resonance imaging (MRI) study. Progress in Neuropsychopharmacology and Biological Psychiatry, 12, 837848.Google Scholar
Uematsu, M. & Kaiya, H. (1989) Midsagittal cortical pathomorphology of schizophrenia: a magnetic resonance imaging study. Psychiatry Research, 30, 1120.Google Scholar
Van Kammen, D. P. (1991) The biochemical basis of relapse and drug response in schizophrenia: a review and hypothesis. Psychological Medicine, 21, 881895.CrossRefGoogle ScholarPubMed
Vita, A., Sacchetti, E., Calzeroni, A., et al (1988) Cortical atrophy in schizophrenia. Prevalence and associated features. Schizophrenia Research, 1, 329337.CrossRefGoogle ScholarPubMed
Vita, A., Dieci, M., Giobbio, G. M., et al (1991) CT scan abnormalities and outcome of chronic schizophrenia. American Journal of Psychiatry, 148, 15771579.Google ScholarPubMed
Wilms, G., Van Ongeval, C., Baert, A. L., et al (1992) Ventricular enlargement, clinical correlates and treatment outcome in chronic schizophrenic patients. Acta Psychiatrica Scandinavica, 85, 306312.Google Scholar
Weinberger, D. R., Fuller Torrey, E., Neophytides, A. N., et al (1979) Structural abnormalities in the cerebral cortex of chronic schizophrenic patients. Archives of General Psychiatry, 36, 935939.Google Scholar
Weinberger, D. R., Cannon-Spoor, E., Potkin, S. G., et al (1980) Poor premorbid adjustment and CT scan abnormalities in chronic schizophrenia. American Journal of Psychiatry, 137, 14101413.Google Scholar
Weinberger, D. R., DeLisi, L. E., Perman, G. P., et al (1982) Computed tomography in schizophreniform disorder and other acute psychiatric disorders. Archives of General Psychiatry, 39, 778783.Google Scholar
Wolkin, A., Barouche, F., Wolf, A. P., et al (1989) Dopamine blockade and clinical response: evidence for two biological subgroups of schizophrenia. American Journal of Psychiatry, 146, 905908.Google Scholar
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