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Axis I comorbidity in bipolar disorder with psychotic features

Published online by Cambridge University Press:  03 January 2018

Stefano Pini ,
Liliana Dell'Osso ,
Concettina Mastrocinque ,
Giovanni Marcacci ,
Alessandra Papasogli ,
Serena Vignoli ,
Stefano Pallanti  and
Giovanni B. Cassano
Stefano Pini*
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Italy
Liliana Dell'Osso
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Italy
Concettina Mastrocinque
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Italy
Giovanni Marcacci
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Italy
Alessandra Papasogli
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Italy
Serena Vignoli
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Italy
Stefano Pallanti
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Italy
Giovanni B. Cassano
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Italy
*
Dr Stefano Pini. DPNFB–Department of Psychiatry, University of Pisa, via Roma 67, 56100 Pisa, Italy. Tel: +39 50 835–419; Fax: +39 50 21–581
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Abstract

Background

Axis I comorbidities are prevalent among patients with severe bipolar disorder but the clinical and psychopathological implications are not clear.

Aims

To investigate characteristics of four groups of patients categorised as follows: substance abuse only (group I), substance abuse associated with other Axis I disorders (group 2), non-substance-abuse Axis I comorbidity (group 3), no psychiatric comorbidity (group 4)

Method

Consecutive patients with bipolar disorder with psychotic features (n=125) were assessed using the Structured Clinical Interview for DSM–III–R – patient version, and several psychopathological scales.

Results

By comparison with group 4, group I had a higher risk of having mood-incongruent delusions, group 2 had an earlier age at onset of mood disorder, a more frequent onset with a mixed state and a higher risk of suicide, and group 3 had more severe anxiety and a better awareness of illness.

Conclusions

Substance abuse, non-substance-abuse Axis I comorbidity and their reciprocal association are associated with different characteristics of bipolar disorder.

Type
Papers
Information
The British Journal of Psychiatry , Volume 175 , Issue 5 , November 1999 , pp. 467 - 471
Copyright
Copyright © 1999 The Royal College of Psychiatrists 

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Footnotes

Declaration of interest

This study was supported by funds from the Department of Psychiatry, University of Pisa.

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