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An Extended Trial of Oxypertine in Five Selected Cases of Chronic Schizophrenia

Published online by Cambridge University Press:  29 January 2018

A. Skarbek  and
G. B. Hill
A. Skarbek
Affiliation:
Psycholinguistic Research Unit, University College, London, W.C.1
G. B. Hill
Affiliation:
The Bayer Products Company, Winthrop House, Surbiton, Surrey; Somerset House, W.C.2
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Extract

The value of oxypertine in the treatment of chronic schizophrenia has been the subject of several clinical trials, the results of which have been reviewed recently (Skarbek and Jacobsen, 1965). In particular a comparison of the effects of oxypertine and trifluoperazine in thirty-five schizophrenic women revealed statistically significant differences between the drugs, oxypertine showing a tendency to activate the withdrawn cases (Calwell, Jacobsen and Skarbek, 1964). An opportunity arose to study five of these patients again under controlled conditions, and it was felt that this would be useful for two reasons. First, it would show whether the response to oxypertine was repeatable, as the patients had meanwhile resumed their previous treatment. Secondly, by a detailed examination over an extended period, using a battery of tests and flexible dosage, a more exact delineation of the optimal symptomatic response to oxypertine could be made.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 113 , Issue 503 , October 1967 , pp. 1107 - 1112
Copyright
Copyright © Royal College of Psychiatrists, 1967 

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References

Calwell, W. P. K., Jacobsen, M., and Skarbek, A. (1964). “A comparative study of oxypertine and trifluoperazine in chronic schizophrenia.” Brit. J. Psychiat., 110, 520–530.Google Scholar
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Venables, P. H. (1957). “A short scale for rating ‘activity-withdrawal’ in schizophrenics.” J. ment. Sci., 103, 197–199.Google Scholar
Wing, J. K. (1961). “A simple and reliable sub-classification of chronic schizophrenia.” Ibid., 107, 862–875.Google Scholar
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