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48-Hour Depressive Cycling induced by Antidepressant

Published online by Cambridge University Press:  29 January 2018

B. Lerer ,
B. Birmacher ,
R. P. Ebstein  and
R. H. Belmaker
B. Lerer
Affiliation:
Department of Psychiatry, Hadassah University Hospital, Jerusalem, Israel; Now Research Fellow, Jerusalem Mental Health Center, POB 140, Jerusalem, Israel
B. Birmacher
Affiliation:
Department of Psychiatry, Hadassah University Hospital, Jerusalem
R. P. Ebstein
Affiliation:
Jerusalem Mental Health Center
R. H. Belmaker
Affiliation:
Jerusalem Mental Health Center, POB 140, Jerusalem, Israel
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Extract

Several cases of increases in frequency of mood cycling have recently been reported in women as a result of tricyclic antidepressant treatment (Siris et al, 1979; Wehr and Goodwin, 1979). We report here the occurrence of 48-hour rapid cycling in a man with recurrent unipolar depression after treatment with dibenzepin (Noveril), an atypical tricyclic antidepressant. Alterations in urinary cyclic adenosine monophosphate (AMP) have been reported with mood changes and were therefore evaluated at the same time.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 137 , Issue 2 , August 1980 , pp. 183 - 185
Copyright
Copyright © Royal College of Psychiatrists, 1980 

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