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[18F]FDG PET Study in Obsessive–Compulsive Disorder

A Clinical/Metabolic Correlation Study after Treatment

Published online by Cambridge University Press:  02 January 2018

Daniela Perani ,
Cristina Colombo ,
Sergio Bressi ,
Annamaria Bonfanti ,
Franco Grassi ,
Silvio Scarone ,
Laura Bellodi ,
Enrico Smeraldi  and
Ferruccio Fazio
Daniela Perani*
Affiliation:
Istituto di Neuroscienze e Bioimmagini CNR
Cristina Colombo
Affiliation:
Istituto Scientifico H San Raffaele
Sergio Bressi
Affiliation:
Istituto Scientifico H San Raffaele
Annamaria Bonfanti
Affiliation:
Istituto Scientifico H San Raffaele
Franco Grassi
Affiliation:
Istituto Scientifico H San Raffaele
Silvio Scarone
Affiliation:
Università degli Studi di Milano
Laura Bellodi
Affiliation:
Università degli Studi di Milano
Enrico Smeraldi
Affiliation:
Università degli Studi di Milano
Ferruccio Fazio
Affiliation:
Università degli Studi di Milano
*
Dr Daniela Perani, Istituto di Neuroscienze and Bioimmagini CNR. c/o H San Raffaele, Via Olgettina 60, 20132 Milan, Italy
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Abstract

Background

We used [18F]FDG and PET in patients with obsessive–compulsive disorder (OCD) to evaluate cerebral metabolic involvement before and after treatment with serotonin-specific reuptake inhibitors.

Method

In 11 untreated, drug-free adults, regional cerebral metabolic rate for glucose (rCMRglu) was compared with that of 15 age-matched normal controls.

Results

rCMRglu values were significantly increased in the cingulate cortex, thalamus and pallidum/putamen complex. After treatment a significant improvement in obsessive–compulsive symptoms on the Y-BOC scale (t = 3.59, P < 0.01) was associated with a significant bilateral decrease of metabolism in the whole cingulate cortex (P < 0.001). Clinical and metabolic data were significantly intercorrelated (Kendall's τ = 0.65; P < 0.01).

Conclusions

These findings indicate that OCD is associated with functional hyperactivity of a selected neuronal network and that treatment to reduce symptoms may have a selective neuromodulatory effect on cingulate cortex.

Type
Papers
Information
The British Journal of Psychiatry , Volume 166 , Issue 2 , February 1995 , pp. 244 - 250
Copyright
Copyright © 1995 The Royal College of Psychiatrists 

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References

Alexander, G. E., Crutcher, M. D. & De Long, M. R. (1990) Basal ganglia-thalamo-cortical circuits: parallel substrates for motor, oculomotor, prefrontal and limbic functions. In Progress in Brain Research (eds Uylins, H. B. M., Van Eden, C. G., Corner, M. A. & Feenstra, M. G. P.). Amsterdam: Elsevier.Google Scholar
American Psychiatric Association (1967) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.Google Scholar
Baxter, L. R., Phelps, M. E., Mazziotta, J. C., et al (1987) Local cerebral glucose metabolic rates in obsessive–compulsive disorder. Archives of General Psychiatry, 44, 211–218.CrossRefGoogle ScholarPubMed
Baxter, L. R., Schwartz, J. M., Bergman, K. S., et al (1992) Caudate glucose metabolic rate changes with both drug and behaviour therapy for obsessive–compulsive disorder. Archives of General Psychiatry, 49, 681–689.CrossRefGoogle ScholarPubMed
Benkelfat, C., Nordahl, T. E., Semple, W. E., et al (1990) Local cerebral glucose metabolic rates in obsessive–compulsive disorder. Archives of General Psychiatry, 47, 840–848.CrossRefGoogle ScholarPubMed
Bettinardi, V., Scardaoni, R., Gilardi, M. C., et al (1991) Head holder for PET, CT and MR studies. Journal of Computed Assisted Tomography, 15, 886–892.CrossRefGoogle ScholarPubMed
Damasio, H., Damasio, A. (1989) Lesion Analysis in Neuropsychology. New York: Oxford University Press.Google Scholar
De Long, M. R., Georgopulos, A. P. (1981) Motor function of the basal ganglia. In Handbook of Physiology (eds Brookhart, J. M., Mountcastle, V. B. & Brooks, V. B.). The Nervous system, 1, pp. 1017–1061. Bethesda, MD: American Physiological Society.Google Scholar
Flament, M. F., Rapoport, J. L., Murphy, D. L., et al (1987) Biochemical changes during climipramine treatment of childhood obsessive–compulsive disorder. Archives of General Psychiatry, 44, 219–225.CrossRefGoogle Scholar
Ford, I., McColl, J. H., McCormack, G., et al (1991) Statistical issues in the analysis of neuroimages. Journal of Cerebral Blood Flow and Metabolism, 11, A89–A95.CrossRefGoogle ScholarPubMed
Friston, K. J., Frith, C. D., Liddle, P. F., et al (1990) The relationship between global and local changes in PET scans. Journal of Cerebral Blood Flow and Metabolism, 10, 458–466.CrossRefGoogle ScholarPubMed
Frith, C. D., Friston, K. J., Liddle, P. F., et al (1991) Willed action and the prefrontal cortex in man: a study with PET. Proceedings of the Royal Society, 224, 241–246.Google Scholar
Garber, H., Ananth, J., Chin, L., et al (1989) Nuclear magnetic resonance study of obsessive–compulsive disorder. American Journal of Psychiatry, 146, 1001–1005.Google ScholarPubMed
Gardner, M. J. & Altman, D. G. (1986) Confidence intervals rather than P values: estimation rather than hypothesis testing. British Medical Journal, 292, 746–750.CrossRefGoogle Scholar
Goodman, W. K., Price, L. H., Rasmussen, S. A., et al (1989a) The Yale-Brown obsessive compulsive scale. II: Validity. Archives of General Psychiatry, 46, 1012–1016.CrossRefGoogle ScholarPubMed
Goodman, W. K., Price, L. H., Rasmussen, S. A., et al (1989b) The Yale-Brown obsessive compulsive scale. I: Development, use and reliability. Archives of General Psychiatry, 46, 1006–1011.CrossRefGoogle ScholarPubMed
Goodman, W. K., Price, L. H., Delgado, P. L., et al (1990) Specificity of serotonin reuptake inhibitors in treatment of obsessive–compulsive disorder. Archives of General Psychiatry, 47, 577–585.CrossRefGoogle ScholarPubMed
Hoen-Saric, R., Pearlson, G. D., Harris, G. J., et al (1991) Effects of fluoxetine on regional cerebral blood flow in obsessive–compulsive patients. American Journal of Psychiatry, 148, 1243–1245.Google Scholar
Hymas, N., Lees, A., Bolton, D., et al (1991) The neurology of obsessional slowness. Brain, 114, 2203–2233.CrossRefGoogle ScholarPubMed
Insel, T. R. & Zohar, J. (1987) Psychopharmacological approaches to obsessive–compulsive disorder. In Psychopharmacology: The Third Generation of Progress (eds Meltzer, H. Y., Coyle, J. T., Kopin, I. J., et al), pp. 1205–1209. New York: Raven Press.Google Scholar
Kaufman, D. M. (1985) Involuntary Movement Disorders. In Clinical Neurology for Psychiatrists, pp. 315–354. Orlando, FL: Grune and Stratton.Google Scholar
Kettl, P. A. & Marks, I. M. (1986) Neurological factors in obsessive–compulsive disorders: two case reports and a review of the literature. British Journal of Psychiatry, 149, 315–319.CrossRefGoogle Scholar
Kupfermann, I. (1991) Localization of higher cognitive and affective functions: the association cortices. In Principles of Neural Science 3rd edn 53 (eds Kandel, E. R., Schwartz, J. H. & Jessell, T. M.), pp. 823–838.Google Scholar
Laplane, D., Degos, J. D., Baulac, M., et al (1981) Bilateral infarction of the anterior cingulate gyri and of the fornices. Journal of Neurological Sciences, 51, 289–300.CrossRefGoogle ScholarPubMed
Luxenberg, J. S., Swedo, S. E., Flament, M. F., et al (1989) Neuroanatomical abnormalities in obsessive–compulsive disorder detected with quantitative X-ray computed tomography. American Journal of Psychiatry, 146, 1089–1093.Google Scholar
McKeon, J., McGuffin, P., Robinson, P. (1984) Obsessive–compulsive neurosis following head injury: a report of four cases. British Journal of Psychiatry, 144, 190–192.CrossRefGoogle ScholarPubMed
Modell, J. G., Mountz, J. M., Curtis, G. C., et al (1989) Neurophysiologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenetic mechanism of obsessive–compulsive disorder. Journal of Neuropsychiatry and Clinical Neurosciences, 1, 27–36.Google ScholarPubMed
Nemeth, G., Hegedus, K. & Molnar, L. (1988) Akinetic mutism associated with bicingular lesions: clinicopathological and functional anatomical correlates. European Archives of Psychiatric and Clinical Neuroscience, 237, 218–222.Google ScholarPubMed
Pardo, J. V., Pardo, P. J., Janer, K. W., et al (1990) The anterior cingulate mediates processing selection in the stroop attentional conflict paradigm. Proceedings of the National Academy of Sciences, 87, 256–259.CrossRefGoogle ScholarPubMed
Passingham, R. E. (1993) The Frontal Lobes and Voluntary Actions. Oxford: Oxford University Press.CrossRefGoogle Scholar
Paus, T., Petrides, M., Evans, A. C., et al (1993) Role of the human anterior cingulate cortex in the control of oculomotor, manual, and speech responses: a positron emission tomography study. Journal of Neurophysiology, 70, 453–469.CrossRefGoogle ScholarPubMed
Peroutka, S. J. & Snyder, S. H. (1980) Chronic antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding. Science, 210, 88–90.CrossRefGoogle Scholar
Reivich, M., Alavi, A., Wolf, A., et al (1985) Glucose metabolic rate kinetic model parameter determination in humans: the lumped constants and rate constants for 18F-fluorodeoxyglucose and 11C-deoxy glucose. Journal of Cerebral Blood Flow and Metabolism, 5, 179–192.CrossRefGoogle ScholarPubMed
Robertson, M. M. (1989) The Gilles de La Tourette Syndrome: the current status. British Journal of Psychiatry, 154, 147–169.CrossRefGoogle ScholarPubMed
Robins, L. N., Heltzer, J., Cottler, L., et al (1989) Diagnostic Interview Schedule. Version III–R (DIS–III–R). St Louis: Washington University School of Medicine.Google Scholar
Sachdev, P., Hay, P. & Cumming, S. (1992) Psychosurgical treatment of obsessive–compulsive disorder. Archives of General Psychiatry, 49, 582–584.CrossRefGoogle ScholarPubMed
Scarone, S., Colombo, C., Livian, S., et al (1992) Increased right caudate nucleus size in obsessive compulsive disorder: detection with magnetic resonance imaging. Psychiatry Research – Neuroimaging, 45, 115–121.CrossRefGoogle ScholarPubMed
Schilder, P. (1938) The organic background of obsessions and compulsions. American Journal of Psychiatry, 94, 1397–1416.CrossRefGoogle Scholar
Swedo, S. E., Schapiro, M., Grady, C., et al (1989) Cerebral glucose metabolism in childhood-onset obsessive–compulsive disorder. Archives of General Psychiatry, 46, 518–522.CrossRefGoogle ScholarPubMed
Swedo, S. E., Pietrini, P., Leonard, H. L., et al (1992) Cerebral glucose metabolism in childhood-onset obsessive–compulsive disorder. Revisualization during pharmacotherapy. Archives of General Psychiatry, 49, 690–694.CrossRefGoogle ScholarPubMed
Talairach, J., Bancaud, J., Geier, S., et al (1973) The cingulate gyrus and human behaviour. Electroencephalography and Clinical Neurophysiology, 34, 45–52.CrossRefGoogle ScholarPubMed
Tork, I. (1990) Anatomy of the Serotonergic System. In The Neuropharmacology of Serotonin. Annals of the New York Academy of Sciences, pp. 9–35. New York: New York Academy of Sciences.Google Scholar
Winer, B. J. (1971) Statistical Principles in Experimental Design (2nd edn). New York: McGraw-Hill.Google Scholar
Zohar, J., Mueller, E. A., Insel, T. R., et al (1987) Serotonergic responsivity in obsessive compulsive disorder: comparison of patients and healthy controls. Archives of General Psychiatry, 44, 946–951.CrossRefGoogle ScholarPubMed
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