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Thalamocortical dysrhythmia syndrome: MEG imaging of neuropathic pain

Published online by Cambridge University Press:  11 October 2005

JOSHUA J. SCHULMAN
Affiliation:
Department of Physiology and Neuroscience, New York University School of Medicine
REY R. RAMIREZ
Affiliation:
Department of Physiology and Neuroscience, New York University School of Medicine
MARTIN ZONENSHAYN
Affiliation:
Department of Neurosurgery, New York University School of Medicine Current Address: Department of Neurosurgery, Weill Medical College of Cornell University
URS RIBARY
Affiliation:
Department of Physiology and Neuroscience, New York University School of Medicine
RODOLFO LLINAS
Affiliation:
Department of Physiology and Neuroscience, New York University School of Medicine

Abstract

Abnormal thalamocortical dynamics have been proposed as the underlying mechanism for a subset of neurological and psychiatric disorders that include centrally generated pain. Spectral analysis and independent component-based localization of neuromagnetic signals reveal ongoing theta-range activity localized to physiologically significant cortical regions in a group of subjects with well-characterized central and peripheral lesions. In addition, recordings from subjects who failed to obtain relief from spinal cord stimulation (SCS) and from those in whom SCS was successful further delineate thalamocortical dysrhythmias as a mechanism that underlies chronic pain.

Type
Research Article
Copyright
© 2005 Cambridge University Press

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