A new, NSF-supported, General Education (GE) science curriculum, synthesizes and unifies the key theories and evidence of seven natural sciences using natural systems processes as Integrative Themes. The considerably reformulated subject matter is completely built on interdisciplinary concepts and methods fundamental to newly emerging cross-disciplinary fields like bioastronomy. The year of ISGE study incorporates 15 built-in computer based multimedia features and 10 special learning features to help non-science students learn more science, faster, and with better understanding. Results from seven test course offerings are reported. ISGE intends to be an initial example of the “living, evolving” knowledge bases needed for a space-faring species.