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Integrative Neuropsychological Characteristics of Subcortical-Frontal Brain Regions as a Schizophrenia Liability Factor

Published online by Cambridge University Press:  10 April 2014

Vera A. Orlova ,
Nina I. Voskresenskaya ,
Nina P. Shcherbakova ,
Natalia K. Korsakova ,
Tatiana D. Savina ,
Elena P. Solenova ,
Natalia N. Efanova  and
Julia V. Malova
Vera A. Orlova*
Affiliation:
Mental Health Research Centre, Russian Academy of Medical Science, Moscow
Nina I. Voskresenskaya
Affiliation:
Mental Health Research Centre, Russian Academy of Medical Science, Moscow
Nina P. Shcherbakova
Affiliation:
Mental Health Research Centre, Russian Academy of Medical Science, Moscow
Natalia K. Korsakova
Affiliation:
Mental Health Research Centre, Russian Academy of Medical Science, Moscow
Tatiana D. Savina
Affiliation:
Mental Health Research Centre, Russian Academy of Medical Science, Moscow
Elena P. Solenova
Affiliation:
Mental Health Research Centre, Russian Academy of Medical Science, Moscow
Natalia N. Efanova
Affiliation:
Mental Health Research Centre, Russian Academy of Medical Science, Moscow
Julia V. Malova
Affiliation:
Mental Health Research Centre, Russian Academy of Medical Science, Moscow
*
Correspondence concerning this article should be addressed to V.A. Orlova: Mental Health Research Centre, Russian Academy of Medical Sciences (RAMS), Zagorodnoe shosse 2, 113152 Moscow, Russia. FAX: (495)114-49-25. E-mail: [email protected]
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Abstract

In order to study neuropsychological characteristics of subcortical-frontal brain regions function and assessment of their relation with vulnerability to schizophrenia 59 patients and 23 controls were investigated using Luria's neuropsychological methods. The analysis established bilateral abnormalities of the function of prefrontal and profound frontal lobe zones in patients as compared with controls. These abnormalities were more predominate in the left hemisphere. Point biserial correlation coefficients of determined integrative neuropsychological indicators with liability to schizophrenia were 0.39 ± 0.11 and 0.28 ± 0.09, for the left and right brain zones respectively. The obtained data permits discussion of the integrative neuropsychological indicators of subcortical-frontal brain regions as potential markers of liability to schizophrenia and confirms the role of structural and functional brain asymmetry in the pathogenesis of schizophrenia.

Para estudiar las características de las regiones cerebrales subcórtico-frontal, se investigaron la función y la evaluación de su relación con la vulnerabilidad a la esquizofrenia en 59 pacientes y 23 controles, empleando los métodos neuropsicológicos de Luria. El análisis estableció anormalidades bilaterales de la función de las zonas lobulares prefrontal y frontal profunda en pacientes comparados con los controles. Estas anormalidades eran más predominantes en el hemisferio izquierdo. Las coeficientes de correlación punto-biserial de algunos indicadores neuropsicológicos integrativos con la vulnerabilidad a la esquizofrenia eran de 0,39 ± 0,11 y 0,28 ± 0,09, respectivamente. Los datos obtenidos llevan a la discusión de los indicadores neuropsicológicos integrativos de regiones subcortical-frontales del cerebro que se revelan como marcadores potenciales de vulnerabilidad a la esquizofrenia y confirma el papel de la asimetría estructural y funcional del cerebro en la patogénesis de la esquizofrenia.

Keywords

neuropsychologysubcortical-frontal regionsschizophrenialiabilityneuropsicologíaregiones subcórtico-frontalesesquizofreniavulnerabilidad
Type
Articles
Information
The Spanish Journal of Psychology , Volume 10 , Issue 2 , November 2007 , pp. 430 - 435
Copyright
Copyright © Cambridge University Press 2007

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