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Monitoring the Stable at the Pasteur Institute

Published online by Cambridge University Press:  01 June 2008

Jonathan Simon
Jonathan Simon*
Affiliation:
Université de Lyon, France
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Argument

Diphtheria serum production in France was dominated by the Pasteur Institute, which equipped a facility at Garches to produce the antitoxin on a large scale. This article treats the background to the founding of this facility, as well as its day-to-day functioning around 1900. The treatment integrates an examination of the practical undertaking of serum production by the Pasteur Institute with an analysis of the popular perception of the Institute and the mixed financing of the whole venture. We particularly emphasize the “industrial” features of this manufacturing process that involved living units of production, showing how bioassays influenced the destiny of the animals producing the serum. Finally, we argue that this monitoring of the horses, seen as serum-producing units, also provided information on the diseases the sera were intended to treat.

Type
Research Article
Information
Science in Context , Volume 21 , Issue 2 , June 2008 , pp. 181 - 200
Copyright
Copyright © Cambridge University Press 2008

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References

Archives de l'Institut Pasteur a. Direction (1888–1940) File “Création du Service de Sérothérapie.”Google Scholar
Archives de l'Institut Pasteur b. Roux, Series 9381–9382.Google Scholar
Anon. 1894a. “L'Écurie du Dr Roux.” Le Matin, 31 October 1894.Google Scholar
Anon. 1894b. Le Petit Journal, 19 October 1894.Google Scholar
Anon. 1894c. Le Petit Journal, 23 October 1894.Google Scholar
Behring, Emil, and Kitasato, Shibasaburo. 1890. “Ueber das Zustandekommen der Diphtherie-Immunität und der Tetanus-Immunität bei Thieren.” Deutsche Medicinische Wochenschrift 16:1113–1114.Google Scholar
Calmette, Gaston. 1894a. Le Figaro, 6 September 1894.Google Scholar
Calmette, Gaston. 1894b. Le Figaro, 29 October 1894.Google Scholar
Calmette, Gaston. 1895. Le Figaro, 2 January 1895.Google Scholar
Galison, Peter. 1987. How Experiments End. Chicago: Chicago University Press.Google Scholar
Gaudillière, Jean-Paul, and Löwy, Ilana, eds. 1998. The Invisible Industrialist: Manufactures and the Production of Scientific Knowledge. Basingstoke: Palgrave Macmillan.CrossRefGoogle Scholar
Geison, Gerald. 1995. The Private Science of Louis Pasteur. Princeton: Princeton University Press.Google Scholar
Gibbons, Michael, Limoges, Camille, Nowotny, Helga, Schwartzman, Simon, Scott, Peter, and Trow, Martin, eds. 1994. The New Production of Knowledge: The Dynamics of Science and Research in Contemporary Societies. London: Sage.Google Scholar
Gradmann, Christoph. 2005. Krankheit im Labor: Robert Koch und die medizinische Bakteriologie, Göttingen: Wallstein.Google Scholar
Hammonds, Evelynn. 1999. Childhood's Deadly Scourge: The Campaign to Control Diphtheria in New York City, 1880–1930. Baltimore: Johns Hopkins University Press.Google Scholar
Hardy, Anne. 2006. “Paul Ehrlich und die Serumproduzenten. Zur Kontrolle des Diphtherieserums in Labor und Fabrik.” Medizinhistorisches Journal 34:51–84.Google Scholar
Lancial, Louis. 1895. Du Nouveau traitement de la diphtérie par le sérum du Dr Roux. Paris: Bapaume.Google Scholar
Lesch, John. 2007. The First Miracle Drugs: How the Sulfa Drugs Transformed Medicine. Oxford: Oxford University Press.Google Scholar
Löwy, Ilana. 1994. “On Hybridizations, Networks and New Disciplines: The Pasteur Institute and the Development of Microbiology in France.” Studies in the History and Philosophy of Science 25:655–688.CrossRefGoogle ScholarPubMed
Madsen, Thorvald. 1897. “Ueber Messung der Stärke des antidiphtherischen Serums.” Zeitschrift für Hygiene und Infektionskrankheiten 24:425–442.Google Scholar
Martin, Louis. 1897. “Production de la toxine diphtérique.” M.D. thesis, Paris Faculty of Medicine.Google Scholar
Mendelsohn, John Andrew. 1996. Cultures of Bacteriology: Formation and Transformation of a Science in France and Germany, 1870–1914. Ph.D. thesis, Princeton University.Google Scholar
Mollaret, Henri H., and Brossollet, Jacqueline. 1993. Yersin. Un pasteurien en Indochine. Paris: Belin.Google Scholar
Pickering, Andrew. 1995. The Mangle of Practice. Chicago: University of Chicago Press.CrossRefGoogle Scholar
Rader, Karen. 2004. Making Mice: Standardizing Animals for American Biomedical Research, 1900–1955. Princeton: Princeton University Press.CrossRefGoogle Scholar
Rheinberger, Hans-Jörg. 1997. Toward a History of Epistemic Things: Synthesizing Proteins in the Test Tube. Stanford University Press.Google Scholar
Roux, Emile, and Martin, Louis. 1894. “Contribution à l'étude de la diphtérie (Sérum-thérapie) (3e Mémoire).” Annales de l'Institut Pasteur 8:609–639.Google Scholar
Shapin, Steven, and Schaffer, Simon. 1985. Leviathan and the Air-Pump: Hobbes, Boyle, and the Experimental Life. Princeton: Princeton University Press.Google Scholar
Silverstein, Arthur M. 1989. A History of Immunology. San Diego: Academic Press.Google Scholar
Simon, Jonathan. 2005. Chemistry, Pharmacy and Revolution in France, 1777–1809. Aldershot: Ashgate.Google Scholar
Throm, Carola. 1995. Das Diphtherieserum. Ein neues Therapieprinzip, seine Entwicklung und Markteinführung. Stuttgart: WVG.Google Scholar
Weindling, Paul. 1991. “Emile Roux et la diphtérie.” In L'Institut Pasteur. Contributions à son histoire, edited by Morange, Michel, 136–143. Paris: La Découverte.Google Scholar
Weindling, Paul. 1992. “Scientific Elites and Laboratory Organisation in fin de siècle Paris and Berlin.” In The Laboratory Revolution in Medicine, edited by Cunningham, Andrew and Williams, Perry, 170–188. Cambridge: Cambridge University Press.Google Scholar