New insight into RNase P RNA structure from comparative analysis of the archaeal RNA

J. KIRK HARRIS; ELIZABETH S. HAAS; DANIEL WILLIAMS; DANIEL N. FRANK; JAMES W. BROWN

doi:10.1017/S1355838201001777

Abstract

A detailed comparative analysis of archaeal RNase P RNA structure and a comparison of the resulting structural information with that of the bacterial RNA reveals that the archaeal RNase P RNAs are strikingly similar to those of Bacteria. The differences between the secondary structure models of archaeal and bacterial RNase P RNA have largely disappeared, and even variation in the sequence and structure of the RNAs are similar in extent and type. The structure of the cruciform (P7–11) has been reevaluated on the basis of a total of 321 bacterial and archaeal sequences, leading to a model for the structure of this region of the RNA that includes an extension to P11 that consistently organizes the cruciform and adjacent highly-conserved sequences.

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New insight into RNase P RNA structure from comparative analysis of the archaeal RNA

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New insight into RNase P RNA structure from comparative analysis of the archaeal RNA

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