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Vitamin D in older people

Published online by Cambridge University Press:  03 March 2014

Miles D Witham  and
Gavin Francis
Miles D Witham*
Affiliation:
Ageing and Health, Medical Research Institute, University of Dundee, UK
Gavin Francis
Affiliation:
Ageing and Health, Medical Research Institute, University of Dundee, UK
*
Address for correspondence: Dr Miles Witham, Ageing and Health, Medical Research Institute, University of Dundee, Ninewells Hospital, Dundee DD1 9SY. Email: [email protected]
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Summary

Vitamin D has a wide range of biological effects beyond calcium and bone metabolism, and low 25-hydroxyvitamin D levels have been associated with many disease states in recent years, including cardiovascular disease, diabetes, infections and cancer. Association studies of vitamin D are notoriously prone to confounding and to reverse causality, however, and current intervention trial data for non-skeletal indications have been disappointing. Vitamin D is indicated for treatment of osteomalacia in older people, falls prevention in institutionalized older people, and as adjunctive therapy for osteoporosis. Large trials currently underway will ascertain whether potentially beneficial effects of vitamin D supplementation on all-cause mortality in older people are borne out.

Keywords

vitamin Dolder peopleclinical trials
Type
Review Article
Information
Reviews in Clinical Gerontology , Volume 24 , Issue 2 , May 2014 , pp. 158 - 171
Copyright
Copyright © Cambridge University Press 2014 

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