Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-07T15:22:31.524Z Has data issue: false hasContentIssue false
  • English
  • Français

The prescribing of nonsteroidal anti-inflammatory drugs in the elderly

Published online by Cambridge University Press:  17 November 2008

R Goorah  and
H Wynne
R Goorah
Affiliation:
University of Newcastle upon Tyne, Newcastle upon Tyne, UK
H Wynne*
Affiliation:
University of Newcastle upon Tyne, Newcastle upon Tyne, UK
*
H Wynne, King Edward Ward Offices, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NEl 4LP, UK.
Get access Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Occasional paper
Information
Reviews in Clinical Gerontology , Volume 5 , Issue 3 , August 1995 , pp. 357 - 363
Copyright
Copyright © Cambridge University Press 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Committee on Safety of Medicines. Update – nonsteroidal anti-inflammatory drugs and serious gastrointestinal adverse reactions. BMJ 1986; 292: 614.Google Scholar
2Baum, C, Kennedy, DL, Forbes, MB. Utilisation of nonsteroidal anti-inflammatory drugs. Arthritis Rheum 1985; 28: 686–92.CrossRefGoogle Scholar
3Walt, R, Katschinski, B, Logan, R, Ashley, J, Langman, M. Rising frequency of ulcer perforations in elderly people in the United Kingdom. Lancet 1986; 8: 489–92.Google Scholar
4Collier, D St J, Pain, JA. Nonsteroidal antiinflammatory drugs and peptic ulcer perforations. Gui 1985; 26: 359–63.Google Scholar
5Sommerville, K, Faulkner, G, Langman, MJS. Nonsteroidal anti-inflammatory drugs and bleeding peptic ulcer. Lancet 1986; i: 462–64.CrossRefGoogle Scholar
6Fries, JF, Williams, CA, Bloch, DA, Michel, BA. Nonsteroidal anti-inflammatory drug associated gastropathy: incidence and risk factor models. Am J Med 1991; 91: 213–22.CrossRefGoogle ScholarPubMed
7Griffin, MR, Piper, JM, Daugherty, JR, Snowden, M, Ray, WA. Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons. Ann Intern Med 1991; 114: 257–63.CrossRefGoogle ScholarPubMed
8Castleden, CM, Pickles, H. Suspected adverse drug reactions in elderly patients reported to the Committee on Safety of Medicines. Br J Clin PHarmacol 1988; 26: 347–51.CrossRefGoogle Scholar
9Lawrence, JS, Bremner, JM, Bier, F. Osteoarthritis: prevalence in the population and relationship between symptoms and X-ray changes. Ann Rheum Res 1966; 25: 1–24.CrossRefGoogle ScholarPubMed
10Felson, DT, Naimark, A, Anderson, J, Kazis, L, Castelli, W, Meenan, RF. The prevalence of knee osteoarthritis in the elderly. Arthritis Rheum 1987; 30: 914–18.CrossRefGoogle ScholarPubMed
11Felson, DT, Anderson, JJ, Naimark, A, Kannel, W, Meenan, RF. The prevalence of chondrocalcinosis in the elderly and its association with knee osteoarthritis. J Rheumatol 1990; 16: 1241–45.Google Scholar
12Dieppe, PA, Frankel, SJ, Toth, B. Is research into the treatment of osteoarthritis with nonsteroidal anti-inflammatory drugs misdirected? Lancet 1993; 341: 353–54.CrossRefGoogle ScholarPubMed
13Amadio, P, Cummings, DM. Evaluation of acetaminophen in the management of osteoarthritis of the knee. Clin Ther Res 1983; 34: 59–66.Google Scholar
14Bradley, JD, Brandt, KD, Katz, BP, Kalisinski, LA, Ryan, SI. Comparison of an anti-inflammatory dose of ibuprofen, an analgesic dose of ibuprofen and acetaminophen in the treatment of patients with osteoarthritis of the knee. N Engl J Med 1991; 325: 87–91.CrossRefGoogle ScholarPubMed
15Parr, G, Darekar, B, Fletcher, A, Bulpitt, CJ. Joint pain and quality fo life: results of a randomised trial. Br J Clin Pharmacol 1989; 27: 235–42.CrossRefGoogle Scholar
16March, L, Irwig, L, Schwarz, J, Simpson, J, Chock, C, Brooks, P. n of 1 trials comparing a nonsteroidal antiinflammatory drug with paracetamol in osteoarthritis. BMJ 1994; 309: 1041–46.CrossRefGoogle ScholarPubMed
17Day, RO, Graham, GG, Williams, KM, Brookes, PM. Variability in response to NSAIDs. Fact or Fiction. Drugs 1988; 36: 643–51.Google Scholar
18Bloom, BS. Cost of treating arthritis and NSAID-related gastrointestinal side effects. Aliment Pharmacol Ther 1988; 2S: 131–39.Google Scholar
19Langman, MJS, Weil, J, Wainwright, P et al. Risks of bleeding peptic ulcer associated with individual nonsteroidal anti-inflammatory drugs. Lancet 1994; 343: 1075–78.CrossRefGoogle Scholar
20Garcia-Rodriguez, LA, Jick, K. Risk of upper gastrointestinal bleeding and perforation associated with individual nonsteroidal anti-inflammatory drugs. Lancet 1994; 343: 769–72.CrossRefGoogle Scholar
21Morgan, GJ, Poland, M, De Lapp, RE. Efficacy and safety of nabumetone versus diclofenac, naproxen, ibuprofen and piroxicam in the elderly. Am J Med 1993; 95 (suppl 2A): 195–265.CrossRefGoogle ScholarPubMed
22Roth, SH, Tindall, EA, Jain, AK et al. A controlled study comparing the effects of nabumetone, ibuprofen, and ibuprofen plus misoprostol on the upper gastrointestinal tract mucosa. Arch Intern Med 1993; 153: 2565–71.Google Scholar
23Laporte, JR, Carne, X, Vidal, X. Upper gastrointestinal bleeding in relation to previous use of analgesics and NSAIDs. Lancet 1991; 337: 85–89.Google Scholar
24Patrono, C, Dunn, MJ. The clinical significance of inhibition of renal prostaglandin synthesis. Kidney Int 1987; 32: 1–12.CrossRefGoogle ScholarPubMed
25Stillman, MT, Schlesinger, PA. Nonsteroidal anti-inflammatory drug nephrotoxicity: should we be concerned? Arch Intern Med 1990; 150: 268–70.Google Scholar
26McCallion, J, McLaren, B, Belch, JJF, Erwin, L. Effects of fenbufen and indomethacin on renal function and prostaglandin synthesis in elderly patients. J Clin Exp Gerontol 1989; 11: 97–105.Google Scholar
27Wilkieson, CA, Erwin, L, Belch, JJF. Effects of nabumetone and indomethacin on renal function and serum prostaglandin synthesis. J Clin Exp Gerontol 1992; 14: 57–63.Google Scholar
28Ritter, MA, Gioe, TJ. The effect of indomethacin on para-articular ectopie ossification following total hip arthroplasty. Clin Orthop 1982; 167: 113–17.Google Scholar
29Rashad, S, Revell, P, Hemingway, A et al. Effects of NSAIDs on the course of osteoarthritis. Lancet 1989; ii: 519–22.CrossRefGoogle Scholar
30Palmoski, MJ, Brandt, KD. Effects of some nonsteroidal anti-inflammatory drugs on prosteoglycan metabolism and organisation in canine articular cartilage. Arthritis Rheum 1983; 23: 1010–20.CrossRefGoogle Scholar
31Wynne, HA, Rawlins, MD. Are systemic levels of NSAIDs relevant to acute upper gastrointestinal haemorrhage? Eur J Clin Pharmacol 1993; 44: 309–13.CrossRefGoogle ScholarPubMed
32Hazes, JMW, Wilman, AJ. Review of UK data on the rheumatic diseases – 2. Rheumatoid arthritis. Br J Rheumatol 1990; 29: 310–12.CrossRefGoogle Scholar
33Capell, HA, Rennie, JAN, Rooney, PJ et al. Patient compliance: a novel method of testing NSAID in RA. J Rheumatol 1979; 6: 584–92.Google Scholar
34Woodhouse, KW, Wynne, H. The pharmacokinetics of nonsteroidal anti-inflammatory drugs in the elderly. Clin Pharmacokinet 1987; 12: 111–22.CrossRefGoogle ScholarPubMed
35Graham, D, Jaszewski, R, Stromatt, S, Brown, J. Treatment of NSAID induced gastric ulcer with misoprostol. Gastroenterology 1990; 98: A52.Google Scholar
36Ballinger, AB, Kumar, PJ, Scott, DL. Misoprostol in the prevention of gastroduodenal damage in rheumatology. Ann Rheum Dis 1992; 51: 1089–93.CrossRefGoogle ScholarPubMed
37Agrawal, NM, Dajani, EZ. Prevention and treatment of ulcers induced by nonsteroidal anti-inflammatory drugs. J Assoc Acad Minor Phys 1992; 3: 142–48.Google ScholarPubMed
38Hawkey, CJ. Nonsteroidal anti-inflammatory drugs and peptic ulcers. BMJ 1990; 300: 278–84.Google Scholar
39Roth, SH, Bennett, RE, Mitchell, CS, Hartman, RJ. Cimetidine therapy in NSAID gastropathy-double blind long term evaluation. Arch Intern Med 1987; 147: 1798–810.Google Scholar
40Graham, DY, Agrawal, N, Roth, SH. Prevention of NSAID-induced gastric ulcer with synthetic prostaglandin, misoprostol – a multicentre double blind, placebo controlled trial. Lancet 1988; ii: 1277–281.CrossRefGoogle Scholar
41Pullar, T, Capell, HA, Millar, A, Brooks, RG. Alternative Medicine: cost and subjective benefit in rheumatoid arthritis. BMJ 1982; 285: 1629–31.Google Scholar
42Mazzuca, SA. Does patient education in chronic disease have therapeutic value? J Chronic Dis 1982; 35: 521–29.CrossRefGoogle ScholarPubMed
43Wynne, H, Campbell, M. Pharmacoeconomics of NSAIDs. Pharmacoeconomics 1993; 31: 107–23.CrossRefGoogle Scholar
44Andersson, S, Fredin, H, Lindbery, H, Sanzen, L, Westlin, N. Ibuprofen and compression bandage treatment of ankle sprains. Acta Orthop Scand 1983; 54: 322–25.CrossRefGoogle ScholarPubMed
45Diebschlag, W, Nocker, W, Bullingham, R. A double-blind study of the efficacy of topical ketorolac tromathamine gel in the treatment of ankle sprain in comparison to placebo and etofenamate. J Clin Pharmacol 1990; 30: 82–89.CrossRefGoogle ScholarPubMed
46Akermark, C, Forsskahl, B. Topical indomethacin in overuse injuries in athletes. Int J Sports Med 1990; 11: 393–96.Google ScholarPubMed
47Goodwin, JS, Regan, M. Cognitive dysfunction associated with naproxen and ibuprofen in the elderly. Arthritis Rheum 1982; 25: 1013–14.CrossRefGoogle ScholarPubMed