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Peri-operative management of older people undergoing surgery

Published online by Cambridge University Press:  20 November 2013

DJH Shipway*
Affiliation:
Proactive Care of Older Patients Undergoing Surgery (POPS), Department of Ageing and Health, Guy's and St Thomas’ NHS Foundation Trust, UK
D Harari
Affiliation:
Proactive Care of Older Patients Undergoing Surgery (POPS), Department of Ageing and Health, Guy's and St Thomas’ NHS Foundation Trust, UK Proactive Care of Older Patients Undergoing Surgery (POPS), Division of Social and Health Service Research, Kings College London, UK
JK Dhesi
Affiliation:
Proactive Care of Older Patients Undergoing Surgery (POPS), Department of Ageing and Health, Guy's and St Thomas’ NHS Foundation Trust, UK
*
Address for correspondence: Dr DJH Shipway, Older Persons Assessment Unit, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK. Email: [email protected]

Summary

Increasing numbers of older people are undergoing both emergency and elective surgery. However, they remain at increased risk of adverse outcome in comparison with younger patients. This may relate to the association of ageing with physiological deterioration, multi-morbidity and geriatric syndromes such as frailty, all of which are independent predictors of adverse post-operative outcome. Although there is an emerging evidence base for the identification and management of these predictors, this has not yet translated into routine clinical practice. Older patients undergoing surgery often receive sub-optimal care and surgical pathways are not well suited to complex older patients with multi-pathology. Evidence is emerging for alternative models of care that incorporate the evolving evidence base for optimal peri-operative management of the older surgical patient, including risk assessment and optimization. This article aims to provide a practical overview of the literature to all disciplines working in this field.

Type
Review Article
Copyright
Copyright © Cambridge University Press 2013 

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References

1United Nations Department of Economic and Social Affairs, Population Division (2012). Population ageing and development. United Nations, New York. Publication Sales No. E.12.XIII.6.Google Scholar
2Christensen, K, Doblhammer, G, Rau, R, Vaupel, JW. Ageing populations: the challenges ahead. Lancet 2009; 374: 1196–208.Google Scholar
3Birrell, F, Johnell, O, Silman, A. Projecting the need for hip replacement over the next three decades: influence of changing demography and threshold for surgery. Ann Rheum Dis 1999; 58: 569–72.Google Scholar
4Roche, JJ, Wenn, RT, Sahota, O, Moran, CG. Effect of comorbidities and postoperative complications on mortality after hip fracture in elderly people: prospective observational cohort study. BMJ 2005; 331: 1374.Google Scholar
5Farhat, JS, Velanovich, V, Falvo, AJet al.Are the frail destined to fail? Frailty index as predictor of surgical morbidity and mortality in the elderly. J Trauma Acute Care Surg 2012; 72: 1526–30; discussion 1530–31.CrossRefGoogle ScholarPubMed
6National Confidential Enquiry into Patient Outcome and Death. An Age Old Problem. A review of the care received by elderly patients undergoing surgery 2010. NCEPOD, London.Google Scholar
7Harari, D, Hopper, A, Dhesi, Jet al.Proactive care of older people undergoing surgery (‘POPS’): designing, embedding, evaluating and funding a comprehensive geriatric assessment service for older elective surgical patients. Age Ageing 2007; 36: 190–96.Google Scholar
8Chow, WB, Rosenthal, RA, Merkow, RPet al.Optimal preoperative assessment of the geriatric surgical patient: a best practices guideline from the American College of Surgeons National Surgical Quality Improvement Program and the American Geriatrics Society. J Am Coll Surg 2012; 215: 453–66.Google Scholar
9Harari, D, Dhesi, J. Surgery in older people: an update. Rev Clin Gerontol 2007; 17: 119–37.Google Scholar
10Poldermans, D, Bax, JJ, Boersma, Eet al.Guidelines for pre-operative cardiac risk assessment and perioperative cardiac management in non-cardiac surgery. Task Force for Preoperative Cardiac Risk Assessment and Perioperative Cardiac Management in Non-cardiac Surgery, European Society of Cardiology (ESC). Eur Heart J 2009; 30: 2769.Google Scholar
11Fleisher, LA, Beckman, JA, Brown, KAet al.American College of Cardiology; American Heart Association Task Force on Practice Guidelines (writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Non-cardiac Surgery). J Am Coll Cardiol 2007; 50: e159241.Google Scholar
12Vahanian, A, Baumgartner, H, Bax, Jet al.Guidelines on the management of valvular heart disease: the Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology. Eur Heart J 2007; 28: 230–68.Google ScholarPubMed
13Heyburn, G, McBrien, ME. Pre-operative echocardiography for hip fractures: time to make it a standard of care. Anaesthesia 2012; 67: 1189–93.Google Scholar
14Morris, CK, Ueshima, K, Kawaguchi, T, Hideg, A, Froelicher, VF. The prognostic value of exercise capacity: a review of the literature. Am Heart J 1991; 122: 1423–31.CrossRefGoogle ScholarPubMed
15Sicari, R, Nihoyannopoulos, P, Evangelista, Aet al.Stress Echocardiography Expert Consensus Statement – Executive Summary: European Association of Echocardiography. Eur Heart J 2009; 30: 278–89.Google Scholar
16Wijeysundera, DN, Wijeysundera, HC, Yun, Let al.Risk of elective major non-cardiac surgery after coronary stent insertion: a population-based study. Circulation 2012; 126: 1355.CrossRefGoogle Scholar
17Burger, W, Chemnitius, JM, Kneissl, GD, Rücker, G. Low-dose aspirin for secondary cardiovascular prevention – cardiovascular risks after its perioperative withdrawal versus bleeding risks with its continuation – review and meta-analysis. J Intern Med 2005; 257: 399414.CrossRefGoogle ScholarPubMed
18Kapetanakis, EI, Medlam, DA, Boyce, SWet al.Clopidogrel administration prior to coronary artery bypass grafting surgery: the cardiologist's panacea or the surgeon's headache? Eur Heart J 2005; 26: 576–83.CrossRefGoogle ScholarPubMed
19Douketis, JD, Spyropoulos, AC, Spencer, FAet al.Perioperative management of antithrombotic therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th edn: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141 (suppl): e326S.CrossRefGoogle Scholar
20Klamroth, R, Gottstein, S, Essers, E, Landgraf, H. Bridging with enoxaparin using a half-therapeutic dose regimen: safety and efficacy. Vasa 2010; 39: 243.CrossRefGoogle ScholarPubMed
21Spyropoulos, AC. Pro: ‘Bridging anticoagulation is needed during warfarin interruption in patients who require elective surgery’. Thromb Haemost 2012; 108: 213.Google ScholarPubMed
22Douketis, JD. Contra: ‘Bridging anticoagulation is needed during warfarin interruption when patients require elective surgery’. Thromb Haemost 2012; 108: 210.Google Scholar
23Heidbuchel, H, Verhamme, P, Alings, Met al.European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patient with non-valvular atrial fibrillation. Europace 2013; 15: 625–51.Google Scholar
24Poldermans, D, Boersma, E, Bax, JJet al.The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery. Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group. N Engl J Med 1999; 341: 1789–94.Google Scholar
25Devereaux, PJ, Yang, H, Yusuf, Set al.Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial. Lancet 2008; 371: 1839–47.Google Scholar
26Bangalore, S, Wetterslev, J, Pranesh, S, Sahney, S, Gluud, C, Messerli, FH. Perioperative b blockers in patients having non-cardiac surgery: a meta-analysis. Lancet 2008; 372: 1962–76.CrossRefGoogle Scholar
27Hindler, K, Shaw, AD, Samuels, J, Fulton, S, Collard, CD, Riedel, B. Improved postoperative outcomes associated with preoperative statin therapy. Anesthesiology 2006; 105: 1260–72.CrossRefGoogle ScholarPubMed
28Williams, TM, Harken, AH. Statins for surgical patients. Ann Surg 2008; 247: 3037.CrossRefGoogle ScholarPubMed
29Ryding, AD, Kumar, S, Worthington, AM, Burgess, D. Prognostic value of brain natriuretic peptide in noncardiac surgery: a meta-analysis. Anesthesiology 2009; 111: 311–19.Google Scholar
30Leibowitz, D, Planer, D, Rott, D, Elitzur, Y, Chajek-Shaul, T, Weiss, AT. Brain natriuretic peptide levels predict perioperative events in cardiac patients undergoing non-cardiac surgery: a prospective study. Cardiology 2008; 110: 266–70.Google Scholar
31Fox, AA, Body, SC. Assessment of preoperative B-type natriuretic peptide in adult surgeries: is it useful? Anesthesiology Analgesia 2011; 112: 1005–7.Google Scholar
32Stone, ME, Salter, B, Fischer, A. Perioperative management of patients with cardiac implantable electronic devices. Br J Anaesth. 2011; 107 (suppl 1): i1626.Google Scholar
33Smetana, GW. Postoperative pulmonary complications: an update on risk assessment and reduction. Cleve Clin J Med 2009; 76 (suppl 4): S6065.Google Scholar
34Myers, K, Hajek, P, Hinds, C, McRobbie, H. Stopping smoking shortly before surgery and postoperative complications: A systematic review and meta-analysis. Arch Intern Med 2011; 171: 983–89.Google Scholar
35Qaseem, A, Snow, V, Fitterman, Net al.Risk assessment for and strategies to reduce perioperative pulmonary complications for patients undergoing non-cardiothoracic surgery: a guideline from the American College of Physicians. Ann Intern Med. 2006; 144: 575–80.Google Scholar
36Cassidy, MR, Rosenkranz, P, McCabe, Ket al.Reducing postoperative pulmonary complications with a multidisciplinary patient care program. JAMA Surg 2013; 1: 16.Google Scholar
37Adesanya, AO, Lee, W, Greilich, NB, Joshi, GP. Perioperative management of obstructive sleep apnea. Chest 2010; 138: 1489–98.Google Scholar
38Lopes Neto, JM, Brandão, LO, Loli, A, Leite, CV, Weber, SA. Evaluation of obstructive sleep apnea in obese patients scheduled for bariatric surgery. Acta Cir Bras 2013; 28: 317–22.Google Scholar
39Feldman-Billard, S, Joubert, M, Morello, Ret al. High prevalence of diabetes mellitus and hospital-related hyperglycaemia in French general wards. Diabetes Metab 2013 (Epub ahead of print, 28 May).Google Scholar
40Management of adults with diabetes undergoing surgery and elective procedures: improving standards. NHS Diabetes. London. April 2011.Google Scholar
41Lipshutz, AK, Gropper, MA. Perioperative glycemic control: an evidence-based review. Anesthesiology 2009; 110: 408–21.Google Scholar
42National Patient Safety Agency. Insulin safety: reducing harm associated with the unsafe use of insulin products; 2010. Available at: http://www.patientsafetyfirst.nhs.uk/Content.aspx?path=/interventions/relatedprogrammes/ medicationsafety/insulin/Google Scholar
43Gustafsson, UO, Thorell, A, Soop, M, Ljungqvist, O, Nygren, J. Haemoglobin A1c as a predictor of postoperative hyperglycaemia and complications after major colorectal surgery. Br J Surg 2009; 96: 1358–64.Google Scholar
44Frisch, A, Chandra, P, Smiley, Det al.Prevalence and clinical outcome of hyperglycemia in the perioperative period in noncardiac surgery. Diabetes Care 2010; 33: 1783–88.Google Scholar
45Partridge, J, Harari, D, Gossage, J, Dhesi, J. Anaemia in the older surgical patient: a review of prevalence, causes, implications and management. J R Soc Med 2013 (Epub ahead of print, 6 June).Google Scholar
46Glance, LG, Dick, AW, Mukamel, DBet al.Association between intraoperative blood transfusion and mortality and morbidity in patients undergoing noncardiac surgery. Anesthesiology 2011; 114: 283–92.Google Scholar
47Goodnough, LT, Maniatis, A, Earnshaw, Pet al.Detection, evaluation, and management of preoperative anaemia in the elective orthopaedic surgical patient: NATA guidelines. J Anaesth 2011; 106: 1322.CrossRefGoogle ScholarPubMed
48Beris, P, Muñoz, M, García-Erce, JA, Thomas, D, Maniatis, A, Van der Linden, P. Perioperative anaemia management: consensus statement on the role of intravenous iron. Br J Anaesth 2008; 100: 599–60.Google Scholar
49Hardwick, ME, Morris, BM, Colwell, CW Jr.Two-dose epoetin alfa reduces blood transfusions compared with autologous donation. Clin Orthop Relat Res 2004; 423: 240–44.Google Scholar
50Carson, JL, Carless, PA, Hebert, PC. Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database Syst Rev 2012; 4: CD002042.Google Scholar
51Carson, JL, Terrin, ML, Noveck, Het al.Liberal or restrictive transfusion in high-risk patients after hip surgery. N Engl J Med 2011; 365: 2453–62.Google Scholar
52Foss, NB, Kristensen, MT, Jensen, PS, Palm, H, Krasheninnikoff, M, Kehlet, H. The effects of liberal versus restrictive transfusion thresholds on ambulation after hip fracture surgery. Transfusion 2009; 49: 227–34.Google Scholar
53Carson, JL, Terrin, ML, Noveck, Het al.Liberal or restrictive transfusion in high-risk patients after hip surgery. N Engl J Med 2011; 365: 2453–62.Google Scholar
54Carson, JL, Grossman, BJ, Kleinman, Set al. Clinical Transfusion Medicine Committee of the AABB. Red blood cell transfusion: a clinical practice guideline from the AABB. Ann Intern Med 2012; 157: 4958.Google Scholar
55Partridge, JS, Harari, D, Dhesi, JK. Frailty in the older surgical patient: a review. Age Ageing 2012; 41: 142–47.Google Scholar
56Makary, MA, Segev, DL, Pronovost, PJet al.Frailty as a predictor of surgical outcomes in older patients. J Am Coll Surg 2010; 210: 901–8.CrossRefGoogle ScholarPubMed
57Dasgupta, M, Rolfson, DB, Stolee, P, Borrie, MJ, Speechley, M. Frailty is associated with postoperative complications in older adults with medical problems. Arch Gerontol Geriatr 2009; 48: 7883.Google Scholar
58Xue, QL. The frailty syndrome: definition and natural history. Clin Geriatr Med 2011; 27: 115.Google Scholar
59Peterson, MJ, Giuliani, C, Morey, MCet al.Health, Aging and Body Composition Study Research Group. Physical activity as a preventative factor for frailty: the health, aging, and body composition study. J Gerontol A Biol Sci Med Sci 2009; 64: 6168.Google Scholar
60O'Doherty, , West, M, Jack, S, Grocott, M. Preoperative aerobic exercise training in elective intra-cavity surgery: a systematic review. Br J Anaesth 2013; 110: 679–89.Google Scholar
61Rolland, Y, Dupuy, C, Abellan van Kan, G, Gillette, S, Vellas, B. Treatment strategies for sarcopenia and frailty. Med Clin North Am 2011; 95: 427–38.Google Scholar
62Singh, NA, Quine, S, Clemson, LMet al.Effects of high-intensity progressive resistance training and targeted multidisciplinary treatment of frailty on mortality and nursing home admissions after hip fracture: a randomized controlled trial. J Am Med Dir Assoc 2012; 13: 2430.Google Scholar
63Cameron, ID, Fairhall, N, Langron, Cet al.A multifactorial interdisciplinary intervention reduces frailty in older people: randomized trial. BMC Med 2013; 11: 65.Google Scholar
64Rait, G, Fletcher, A, Smeeth, L et al. Prevalence of cognitive impairment: results from the MRC trial of assessment and management of older people in the community. Age Ageing. 2005; 34: 242–48.Google Scholar
65Borson, S, Scanlan, JM, Chen, P, Ganguli, M. The Mini-Cog as a screen for dementia: validation in a population-based sample. J Am Geriatr Soc 2003; 51: 1451–54.Google Scholar
66Crosby, G, Culley, DJ, Hyman, BT. Preoperative cognitive assessment of the elderly surgical patient: a call for action. Anesthesiology 2011; 114: 1265–68.Google Scholar
67Robinson, TN, Raeburn, CD, Tran, ZV, Angles, EM, Brenner, LA, Moss, M. Postoperative delirium in the elderly: risk factors and outcomes. Ann Surg 2009; 249: 173–78.Google Scholar
68Marcantonio, ER, Flacker, JM, Wright, RJ, Resnick, NM. Reducing delirium after hip fracture: a randomized trial. J Am Geriatr Soc 2001; 49: 516–22.Google Scholar
69Chen, CC, Lin, MT, Tien, YW, Yen, CJ, Huang, GH, Inouye, SK. Modified hospital elder life program: effects on abdominal surgery patients. J Am Coll Surg 2011; 213: 245–52.Google Scholar
70Teslyar, P, Stock, VM, Wilk, CM, Camsari, U, Ehrenreich, MJ, Himelhoch, S. Prophylaxis with antipsychotic medication reduces the risk of post-operative delirium in elderly patients: a meta-analysis. Psychosomatics. 2013; 54: 124–31.Google Scholar
71Al-Aama, T, Brymer, C, Gutmanis, I, Woolmore-Goodwin, SM, Esbaugh, J, Dasgupta, M. Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial. Int J Geriatr Psychiatry. 2011; 26: 687–94.Google Scholar
72American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders (5th edn), pp. 525. Arlington, VA: American Psychiatric Publishing. ISBN 978-0-89042-555-8.Google Scholar
73Moller, JT, Cluitmans, P, Rasmussen, LSet al.Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction. Lancet 1998; 351: 857–61.Google Scholar
74Sztark, F, Le Goff, M, André, D, Ritchie, K, Dartigues, JF, Helmer, C. Exposure to general anaesthesia could increase the risk of dementia in elderly. Euroanaesthesia 2013; abstract 18AP1-4.Google Scholar
75Kristjansson, SR, Spies, C, Veering, BTHet al.Perioperative care of the elderly oncology patient: a report from the SIOG task force on the perioperative care of older patients with cancer. J Ger Oncol 2012; 3: 147–62.Google Scholar
76Gnjidic, D, Hilmer, SN, Blyth, FMet al.Polypharmacy cut-off and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. J Clin Epidemiol 2012; 65: 989–95.Google Scholar
77Balentine, CJ, Hermosillo-Rodriguez, J, Robinson, CN, Berger, DH, Naik, AD. Depression is associated with prolonged and complicated recovery following colorectal surgery. J Gastrointest Surg 2011; 15: 1712–17.Google Scholar
78Bozic, KJ, Lau, E, Kurtz, S, Ong, K, Berry, DJ. Patient-related risk factors for postoperative mortality and periprosthetic joint infection in medicare patients undergoing TKA. Clin Orthop Relat Res 2012; 470: 130–37.Google Scholar
79Auerbach, AD, Vittinghoff, E, Maselli, J, Pekow, PS, Young, JQ, Lindenauer, PK. Perioperative use of selective serotonin reuptake inhibitors and risks for adverse outcomes of surgery. JAMA Intern Med 2013; 173: 1075–81.Google Scholar
80Kudoh, A, Katagai, H, Takazawa, T. Antidepressant treatment for chronic depressed patients should not be discontinued prior to anesthesia. Can J Anaesth 2002; 49: 132–36.Google Scholar
81Abdulla, A, Adams, N, Bone, M, Elliott, AM, Gaffin, J, Jones, D, Knaggs, R, Martin, D, Sampson, L, Schofield, P. Guidance on the management of pain in older people. Age Ageing 2013; 42 (suppl 1): i157.CrossRefGoogle ScholarPubMed
82Post-operative pain management. In Bader, P, Echtle, D, Fonteyne, V, Livadas, K, De Meerleer, G, Paez Borda, A, Papaioannou, EG, Vranken, JH. Guidelines on Pain Management, pp. 6182. Arnhem, The Netherlands: European Association of Urology (EAU); 2010.Google Scholar
83Farrell, C, McConaghy, P. Perioperative management of patients taking treatment for chronic pain. BMJ 2012; 345: 3942.Google Scholar
84Ho, KY, Gan, TJ, Habib, AS. Gabapentin and postoperative pain – a systematic review of randomized controlled trials. Pain 2006; 126: 91101.Google Scholar
85Aubrun, F, Marmion, F. The elderly patient and postoperative pain treatment. Best Pract Res Clin Anaesthesiol 2007; 21: 109–27.Google Scholar
86Lisi, DM. Patient-controlled analgesia and the older patient. US Pharm 2013; 38: HS26.Google Scholar
87Edington, J, Boorman, J, Durrant, ERet al.Prevalence of malnutrition on admission to four hospitals in England. The Malnutrition Prevalence Group. Clin Nutr 2000; 19: 191–95.Google Scholar
88Charlton, K, Nichols, C, Bowden, Set al.Poor nutritional status of older subacute patients predicts clinical outcomes and mortality at 18 months of follow-up. Eur J Clin Nutr 2012; 66: 1224–28.Google Scholar
89Banh, L. Serum proteins as markers of nutrition: what are we treating? Practical Gastroenterology October 2006; 4664.Google Scholar
90Lomivorotov, VV, Efremov, SM, Boboshko, VAet al.Evaluation of nutritional screening tools for patients scheduled for cardiac surgery. Nutrition 2013; 29: 436–42.Google Scholar
91Braga, M, Ljungqvist, O, Soeters, P, Fearon, K, Weimann, A, Bozzetti, F. ESPEN Guidelines on Parenteral Nutrition: surgery. Clin Nutr 2009; 28: 378–86.Google Scholar
92Brady, M, Kinn, S, Stuart, P. Preoperative fasting for adults to prevent peri-operative complications. Cochrane Database Syst Rev 2003; 4: CD004423.Google Scholar
93Gustafsson, UO, Scott, MJ, Schwenk, Wet al. Enhanced Recovery After Surgery (ERAS) Society, for Perioperative Care; European Society for Clinical Nutrition and Metabolism (ESPEN); International Association for Surgical Metabolism and Nutrition (IASMEN). Guidelines for perioperative care in elective colonic surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations. World J Surg 2013; 37: 259–84.Google Scholar
94Genther, DJ, Gourin, CG. The effect of alcohol abuse and alcohol withdrawal on short-term outcomes and cost of care after head and neck cancer surgery. Laryngoscope 2012; 122: 1739–47.CrossRefGoogle ScholarPubMed
95Oppedal, K, Møller, AM, Pedersen, B, Tønnesen, H. Preoperative alcohol cessation prior to elective surgery. Cochrane Database Syst Rev 2012; 7: CD008343.Google Scholar
96Agabio, R, Gessa, GL, Montisci, Aet al.Use of the screening suggested by the National Institute on Alcohol Abuse and Alcoholism and of a newly derived tool for the detection of unhealthy alcohol drinkers among surgical patients. J Stud Alcohol Drugs 2012; 73: 126–33.Google Scholar
97Nguyen, YL, Angus, DC, Boumendil, A, Guidet, B. The challenge of admitting the very elderly to intensive care. Ann Intensive Care 2011; 1: 29.CrossRefGoogle ScholarPubMed
98Tabah, A, Philippart, F, Timsit, JFet al. Quality of life in patients aged 80 or over after ICU discharge. Crit Care 2010; 14: R2.Google Scholar
99Simchen, E, Sprung, CL, Galai, Net al.Survival of critically ill patients hospitalized in and out of intensive care units under paucity of intensive beds. Crit Care Med 2004; 32: 1654–61.Google Scholar
100Cavaliere, F, Conti, G, Costa, R, Masieri, S, Antonelli, M, Proietti, R. Intensive care after elective surgery: a survey on 30-day postoperative mortality and morbidity. Minerva Anestesiol 2008; 74: 459–68.Google Scholar
101Stringer, W, Casaburi, R, Older, P. Cardiopulmonary exercise testing: does it improve perioperative care and outcome? Curr Opin Anaesthesiol 2012; 25: 178–84.Google Scholar
102Tran Ba Loc, P, du Montcel, ST, Duron, JJet al.Elderly POSSUM, a dedicated score for prediction of mortality and morbidity after major colorectal surgery in older patients. Br J Surg 2010; 97: 396403.Google Scholar
103Kamath, AF, McAuliffe, CL, Baldwin, KD, Lucas, JB, Kosseim, LM, Israelite, CL. Unplanned admission to the intensive care unit after total hip arthroplasty. J Arthroplasty 2012; 27: 1027–32.Google Scholar
104Kamath, AF, Gutsche, JT, Kornfield, ZN, Baldwin, KD, Kosseim, LM, Israelite, CL. Prospective study of unplanned admission to the intensive care unit after total hip arthroplasty. J Arthroplasty 2013 (Epub ahead of print, 15 March).Google Scholar
105Khuri, SF, Henderson, WG, DePalma, RG, Mosca, C, Healey, NA, Kumbhani, DJ; Participants in the VA National Surgical Quality Improvement Program. Determinants of long-term survival after major surgery and the adverse effect of postoperative complications. Ann Surg 2005; 242: 326–41.Google Scholar
106Department of Health. Delivering enhanced recovery: helping patients to get better sooner after surgery; 2010. Available at: http://www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/@dh/@en/@ps/documents/digitalasset/dh_115156.pdfGoogle Scholar
107The Association of Anaesthetists of Great Britain and Ireland. Pre-operative assessment and patient preparation – the role of the Anaesthetist; 2010. Available at: www.aagbi.org/sites/default/files/preop2010.pdfGoogle Scholar
108Kamal, T, Conway, RM, Littlejohn, I, Ricketts, D. The role of a multidisciplinary pre-assessment clinic in reducing mortality after complex orthopaedic surgery. Ann R Coll Surg Engl 2011; 93: 149–51.Google Scholar