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Myeloproliferative disorders in older people

Published online by Cambridge University Press:  03 January 2012

Wendy Osborne ,
Gail L Jones ,
Graham H Jackson  and
Helen Marr
Wendy Osborne
Affiliation:
Department of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, UK
Gail L Jones*
Affiliation:
Department of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, UK
Graham H Jackson
Affiliation:
Department of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, UK
Helen Marr
Affiliation:
Department of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, UK
*
Address for correspondence: Dr Gail L Jones, Department of Haematology, Freeman Hospital, Newcastle upon Tyne NE7 7DN. Email: [email protected]
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Summary

The term myeloproliferative disorders (MPDs) describes a group of conditions in which an intrinsic stem cell defect is present in the bone marrow. This leads to hypercellularity in one or more of the myeloid cell lines (red blood cells, platelets, granulocytes and their precursors), or increased bone marrow fibrosis. MPDs are rare; combined annual incidence is 6 per 100,000.

MPDs may present in asymptomatic patients as an incidental finding, or may be associated with constitutional features such as weight loss, sweats or lethargy. Splenomegaly is common but lymphadenopathy is not a feature. The most significant complications are: arterial thrombosis, venous thrombosis, secondary marrow fibrosis and transformation to acute myeloblastic leukaemia (AML). Treatment aims to reduce the risk of such complications.

Recent advances in the understanding of the pathogenesis of these disorders have radically changed the approach to the diagnosis of MPD and are the focus of new treatment developments.

Keywords

elderlymyeloproliferativemyelofibrosisessential thrombocythaemiapolycythaemia verachronic myeloid leukaemia
Type
Clinical geriatrics
Information
Reviews in Clinical Gerontology , Volume 22 , Issue 2 , May 2012 , pp. 108 - 118
Copyright
Copyright © Cambridge University Press 2012

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