Inflammation is an innate immunological response that fends off or repairs injuries caused by foreign agents as part of an essential defence mechanism. There are two main classifications of the inflammatory process, based on its intensity and time-dependent responses: an acute, rapid response with resolution or a low-grade, chronic process without resolution. In this review, the latter case of a long sustaining inflammatory process is discussed in relation to aging. Many epidemiological and experimental studies in recent years report on the age-related activation of inflammatory processes by showing age-related increases in the activities of many pro-inflammatory mediators such as, NFkß, TNFα, IL-1, IL-6, C-reactive protein (CRP), thromboxane A, adhesion molecules, and free fatty acids.