1Parmley, WW.Pathophysiology and current therapy of congestive heart failure. J Am Coll Cardiol 1989; 13: 771–85.CrossRefGoogle ScholarPubMed

2Grossman, W.Diastolic dysfunction in congestive heart failure. N Engl J Med 1991; 325: 1557–64.Google ScholarPubMed

3Kannel, WB, Belanger, AJ.Epidemiology of heart failure. Am Heart J 1991; 121: 951–57.CrossRefGoogle ScholarPubMed

4Francis, GS, Cohn, JN.The autonomic nervous system in congestive heart failure. Annu Rev Med 1986; 37: 235–47.CrossRefGoogle ScholarPubMed

5Passik, CS, Ackerman, DM, Plut, H Jr, Edwards, WD.Temporal changes in the causes of aortic stenosis: a surgical pathologic study of 646 cases. Mayo Clin Proc 1987; 62: 119–23.CrossRefGoogle ScholarPubMed

6Nestico, PF, Depace, NL, Morganroth, J, Kotler, MN, Ross, J.Mitral annular calcification: clinical, pathophysiology and echocardiographic review. Am Heart J 1984; 107: 989–96.CrossRefGoogle ScholarPubMed

7Terpenning, MS, Buggy, BP, Kaufman, CA.Infective endocarditis: clinical features in young and elderly patients. Am J Med 1987; 83: 626–34.CrossRefGoogle ScholarPubMed

8Rodeheffer, RJ, Gerstenblith, G, Becker, LC, Fleg, JL, Weisfeldt, ML, Lakatta, EG.Exercise cardiac output is maintained with advancing age in healthy human subjects: cardiac dilation and increased stroke volume compensate for a diminished heart rate. Circulation 1984; 69: 203–209.CrossRefGoogle ScholarPubMed

9Miyatake, K, Okamoto, M, Kinoshita, N et al. Augmentation of atrial contribution to left ventricular inflow with aging as assessed by intracardiac Doppler flowmetry. Am J Cardiol 1984; 53: 586–89.Google Scholar

10Wong, WF, Gold, S, Fukuyama, O, Blanchette, PL.Diastolic dysfunction in elderly patients with congestive heart failure. Am J Cardiol 1989; 63: 1526–28.CrossRefGoogle ScholarPubMed

11Kuo, LC, Quinones, MA, Rokey, R, Sartori, M, Abinader, EG, Zoghbi, WA.Quantification of a trial contribution to left ventricular filling by pulsed dopper echocardiograph and the effect of age in normal and diseased heartS. Am J Cardiol 1987; 59: 1174–78.CrossRefGoogle Scholar

12Kannel, WB, Castelli, WP, McNamara, PM, McKee, PA, Feinleib, M.The role of blood pressure in the development of congestive heart failure. N Engl J Med 1972; 287: 781–87.CrossRefGoogle ScholarPubMed

13Topol, EJ, Traill, TA, Fortuin, NJ.Hypertensive hypertrophic cardiomyopathy of the elderly. N Engl J Med 1985; 312: 277–83.CrossRefGoogle ScholarPubMed

14Whiting, RB, Powell, WJ, Dinsmore, RE et al. Idiopathic hypertrophic subaortic stenosis in the elderly. N Engl J Med 1971; 285: 196–200.Google Scholar

15Lever, HM, Karam, RF, Currie, PJ, Healy, BP.Hypertrophic cardiomyopathy in the elderly. Distinctions from the young based on cardiac shape. Circulation 1989; 79: 580–89.CrossRefGoogle Scholar

16Shenoy, MM, Khanna, A, Nejat, M, Greif, E, Friedman, SA.Hypertrophic cardiomyopathy in the elderly. A frequently misdiagnosed disease. Arch Intern Med 1986; 146: 658–61.CrossRefGoogle ScholarPubMed

17Fay, WP, Taliercio, CP, Ilstrup, DM, Tajik, AJ, Gersh, BJ.Natural history of hypertrophic cardiomyopathy in the elderly. J Am Coll Cardiol 1990; 16: 821–26.CrossRefGoogle ScholarPubMed

18Spodick, DH, Quarry-Poigott, VM.Fourth heart sound as a normal finding in older persons. N Engl J Med 1973; 288: 140–41.CrossRefGoogle ScholarPubMed

19Levy, D, Labib, SB, Anderson, KM, Christiansen, JC, Kannel, WB, Castelli, WP.Determinants of sensitivity and specificity of electrocardiographic criteria for left ventricular hypertrophy. Circulation 1990; 81: 815–20.CrossRefGoogle ScholarPubMed

20Matsuzaki, M, Toma, Y, Kusukawa, R.Clinical applications of transesophageal echocardiography. Circulation 1990; 82: 709–22.CrossRefGoogle ScholarPubMed

21Soufer, R, Wohlagelemer, D, Vita, NA et al. Intact systolic left ventricular function in clinical congestive heart failure. Am J Cardiol 1985; 55: 1032–36.Google Scholar

22Cohn, JN, Levine, TB, Olivari, MT et al. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med 1984; 311: 819–23.Google Scholar

23Goldsmith, SR, Francis, GS, Cowley, AW et al. Increased plasma arginine vasopressin in patients with congestive heart failure. J Am Coll Cardiol 1983; 1: 1385–90.Google Scholar

24Packer, M, Lee, WH, Kessler, PD et al. Role of neurohormonal mechanisms in determining survival in patients with severe chronic heart failure. Circulation 1987; 75: (suppl IV): IV80–92.Google Scholar

25Cohn, JN, Archibald, DG, Ziesche, S et al. Effect of vasodilator therapy on mortality in chronic congestive heart failure: Results of a Veterans Administration co-operative study. N Engl J Med 1986; 314: 1547–52.Google Scholar

26The Consensus Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure. N Engl J Med 1987; 316: 1429–35.CrossRefGoogle Scholar

27SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 1991; 325: 293–302.CrossRefGoogle Scholar

28Cohn, JN, Johnson, G, Ziesche, S et al. A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. NEngl JMed 1991; 325: 303–10.Google Scholar

29Franciosa, JA, Jordan, RA, Wilen, MM et al. Minoxidil in patients with left heart failure: contrasting hemodynamic and clinical effects in a controlled trial. Circulation 1984; 70: 63–69.Google Scholar

30Markham, RV, Corbett, JR, Gilmore, A et al. Efficacy of prazosin in the management of chronic congestive heart failure: a 6 month randomized double blind, placebo-controlled study. Am J Cardiol 1983; 51: 1346–52.Google Scholar

31Miller, AB, Conetta, SA, Bass, TA.Sublingual nifedipine: acute effects in severe chronic congestive heart failure secondary to idiopathic dilated cardiomyopathy. Am J Cardiol 1985; 55: 1359–62.CrossRefGoogle ScholarPubMed

32Walsh, RW, Porter, CB, Starling, MR et al. Beneficial hemodynamic effects of intravenous and oral diltiazem on severe congestive heart failure. J Am Coll Cardiol 1984; 3: 1044–50.Google Scholar

33Francis, GS.Calcium channel blockers and congestive heart failure. Circulation 1991; 83: 336–38.CrossRefGoogle ScholarPubMed

34Packer, M.Pathophysiological mechanisms underlying the adverse effects of calcium channel-blocking drugs in patients with chronic heart failure. Circulation 1989; 80 (suppl IV): IV59–67.Google ScholarPubMed

35Sica, DA, Gher, T. Diuretics in congestive heart failure. Cardiol Clin 1989; 7: 87–97.CrossRefGoogle ScholarPubMed

36Keermans, ALM, Tan, Y, Vanbaars, H, Van Ginmneken, GAM, Gribeau, FWJ.Furosemide kinetics and dynamics in aged patients. Clin Pharmacol Ther 1983; 34: 181–89.CrossRefGoogle Scholar

37Chaudry, AY, Bing, RF, Castleden, CM, Swales, JD, Napier, CJ.The effect of aging on the response to furosemide in normal subjects. Eur J Clin Pharmacol 1984; 27: 303–306.CrossRefGoogle Scholar

38Kulick, DL, Rahmatoola, SH.Current role of digitalis therapy in patients with congestive heart failure. JAMA 1991; 265: 2995–97.CrossRefGoogle ScholarPubMed

39Captopril-Digoxin Multicenter Research Group. Comparative effects of therapy with captopril and digoxin in patients with mild to moderate heart failure. JAMA 1988; 259: 539–44.CrossRefGoogle Scholar

40Reg, JL, Gottlieb, SH, Lakatta, EG.Is digoxin really important in treatment of compensated heart failure? A placebo-controlled crossover study in patients with sinus rhythm. Am J Med 1982; 73: 244–50.Google Scholar

41Liang, CS, Sherman, LG, Doherty, JU, Wellington, K, Lee, VW, Hood, WB Jr.Sustained improvement of cardiac function in patients with congestive heart failure after short-term infusion of dobutamine. Circulation 1984; 69: 113–19.CrossRefGoogle ScholarPubMed

42Rich, MW, Imburgia, M. Inotropic response to dobutamine in elderly patients with decompensated heart failure. Am J Cardiol 1990; 65: 519–21.CrossRefGoogle Scholar

43Packer, M, Carver, JR, Rodeheffer, RJ et al. Effect of oral milrinone on mortality in severe chronic heart failure. N Eng U Med 1991; 325: 1468–75.Google Scholar

44Edmunds, LH Jr, Stephenson, LW, Edie, RN, Ratcliffe, MB. Open-heart surgery in octogenarians. N Engl J Med 1988; 319: 131–36.CrossRefGoogle ScholarPubMed

45Naunheim, KS, Dean, PA, Fiore, AC et al. Cardiac surgery in the octogenarian. Eur J Cardio-thoracSurg 1990; 4: 130–35.Google Scholar

46Freeman, WK, Schaff, HV, O'brien, PC, Orszulak, TA, Naessens, JM, Tajik, AJ.Cardiac surgery in the octogenarian: perioperative outcome and clinical follow-up. J Am Coll Cardiol 1991; 18: 29–35.CrossRefGoogle ScholarPubMed

47Cribier, A, Savin, T, Berland, J et al. Percutaneous transluminal balloon valvuloplasty of adult aortic stenosis: report of 92 cases. J Am Coll Cardiol 1987; 9: 381–86.Google Scholar

48Safian, RD, Berman, AD, Diver, DJ et al. Balloon aortic valvuloplasty in 170 consecutive patients. N Eng U Med 1988; 319: 125–30.Google Scholar

49Abascal, VM, Wilkins, ET, O'shea, JP et al. Prediction of successful outcome in 130 patientsundergoing percutaneous balloon mitral valvotomy. Circulation 1990; 82: 448–56.Google Scholar

50Herrmann, HC, Kleaveland, JP, Hill, JA et al. The M-Heart Percutaneous Balloon Mitral Valvuloplasty Registry: initial results and early follow-up. J Am Coll Cardiol 1990; 15: 1221–26.Google Scholar

51Palacios, IF, Block, PC, Wilkins, ET, Weyman, AE.Follow-up of patients undergoing percutaneous mitral balloon valvotomy: analysis of factors determining restenosis. Circulation 1989; 79: 573–79.CrossRefGoogle ScholarPubMed

52Litvack, F, Jakubowski, AT, Buchbinder, NA, Eigler, N.Lack of sustained improvement in an elderly population after percutaneous aortic valvuloplasty. Am J Cardiol 1988; 62: 270–75.CrossRefGoogle Scholar

53Fleg, JL, Kennedy, HL.Cardiac arrhythmias in a healthy elderly population: detection by 24-hour ambulatory electrocardiography. Chest 1982; 81: 302–307.CrossRefGoogle Scholar

54Kantelop, JP, Sage, E, Duchene-Marallaz, P.Findings in ambulatory electrocardiographic monitoring in subjects older than 80 years. Am J Cardiol 1986; 57: 398–401.CrossRefGoogle Scholar

55Camm, AJ, Evans, KE, Ward, DE, Martin, A.The rhythm of the heart in active elderly subjects. Am Heart J 1980; 99: 598–603.CrossRefGoogle ScholarPubMed

56Kannel, WB, Abbott, RD, Savage, DD, McNamara, PM.Epidemiologic features of chronic atrial fibrillation: The Framingham Study. N Eng U Med 1982; 306: 1018–22.CrossRefGoogle ScholarPubMed

57Cerebral Embolism Task Force. Cardiogenic brain embolism. Arch Neural 1986; 43: 71–84.CrossRefGoogle Scholar

58Wolf, PA, Abbott, RD, Kannel, WB.Atrial fibrillation as an independent risk factor for stroke: The Framingham Study. Stroke 1991; 22: 983–88.CrossRefGoogle ScholarPubMed

59Petersen, P, Boysen, G, Gotfredsen, J, Andersen, ED, Andersen, B.Placebo-controlled, randomized trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK Study. Lancet 1989; 1: 175–79.CrossRefGoogle ScholarPubMed

60Stroke Prevention in Atrial Fibrillation Investigators. Stroke Prevention in Atrial Fibrillation Study: final results. Circulation 1991; 84: 527–39.CrossRefGoogle Scholar

61The Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators. The effect of low-dose warfarin on the risk of stroke in patients with nonrheumatic atrial fibrillation. N Eng U Med 1990; 323: 1505–11.CrossRefGoogle Scholar

62Platia, EV, Michelson, EL, Porterfield, JK, Das, G.Esmolol versus verapamil in the acute treatment of atrial fibrillation or atrial flutter. Am J Cardiol 1989; 63: 925–29.CrossRefGoogle ScholarPubMed

63Waxman, HL, Myerburg, RJ, Appel, R, Sung, RJ.Verapamil for control of ventricular rate of paroxysmal supraventricular tachycardia and atrial fibrillation or flutter. A double-blind randomized cross-over study. Ann Intern Med 1981; 94: 1–6.CrossRefGoogle ScholarPubMed

64Ditrich, HC, Erickson, JS, Schneiderman, T, Blacky, AR, Savides, T, Nicod, PH.Echocardiographic predictors for outcome of elective cardioversion of atrial fibrillation. Am J Cardiol 1989; 63: 193–97.CrossRefGoogle Scholar

65Brodsky, MA, Allen, BJ, Capparelli, EV, Luckett, CR, Morton, R, Henry, WL.Factors determining maintenance of sinus rhythm after chronic atrial fibrillation with left atrial dilatation. Am J Cardiol 1989; 63: 1065–68.CrossRefGoogle ScholarPubMed

66Hoglund, C, Rosenhamer, G.Echocardiographic left atrial dimension as a predictor of maintaining sinus rhythm after conversion of atrial fibrillation. Acta Med Scand 1985; 217: 411–15.CrossRefGoogle ScholarPubMed

67McLenachan, JM, Henderson, E, Morris, KL, Dargie, HJ.Ventricular arrhythmias in patients with hypertensive left ventricular hypertrophy. N Eng U Med 1987; 317: 787–92.CrossRefGoogle ScholarPubMed

68Messerli, FH, Ventura, HO, Elizardi, DG, Drelinski, GR, Dunn, FG, Frohlich, ED.Hypertension and sudden death: increased ventricular ectopic activity in left ventricular hypertrophy. Am J Med 1984; 77: 18–22.CrossRefGoogle ScholarPubMed

69Parmley, WW, Chatterjee, K.Congestive heart failure and arrhythmias: an overview. Am J Cardiol 1986; 57: 34–378.CrossRefGoogle ScholarPubMed

70The CAST Investigators. Effect of encainide and flecainide on mortality in a randomized trial of arrhythmic suppression after myocardial infarction. N Engl J Med 1989; 321: 406–12.CrossRefGoogle Scholar

71Pratt, CM, Delclos, G, Wierman, AM et al. The changing baseline of complex ventricular arrhythmias: a new consideration in assessing long-term antiarrhythmic drug therapy. N Engl J Med 1985; 313: 1444–49.Google Scholar

72Toivomen, L.Spontaneous variability in the frequency of ventricular premature complexes over prolonged intervals and implications for antiarrhythmic treatment. Ami Cardiol 1987; 60: 608–12.CrossRefGoogle Scholar

73Shibata, T, Kubota, I, Ikeda, K, Tsuiki, K, Yasui, S.Body surface mapping of high frequency components in the terminal portion during QRS complex for the prediction of ventricular tachycardia in patients with previous myocardial infarction. Circulation 1990; 82: 2084–92.CrossRefGoogle ScholarPubMed

74Wellens, HJJ, Brusader, P, Stevenson, WG.Programmed electrical stimulation of the heart in patients with life threatening ventricular arrhythmias: what is the significance of induced arrhythmias and what is the correct stimulation protocol? Circulation 1985; 72: 1–7.CrossRefGoogle ScholarPubMed

75Kastor, JA, Horowitz, LN, Harken, AH, Josephson, ME.Clinical electrophysiology of ventricular tachycardia. N Engl J Med 1981; 304: 1004–20.CrossRefGoogle ScholarPubMed

76Tresch, DD, Troup, PJ, Thaker, RK et al. Comparison of efficacy of automatic implantable cardioverter defibrillator in patients older and younger than 65 years of age. Am J Med 1991; 90: 717–24.Google Scholar

77Singh, BN, Kaplinsky, E, Kirsten, E, Guerrero, J.Effects of propafenone on ventricular arrhythmias: double-blind, parallel, randomized, placebo-controlled dose-ranging study. Am Heart J 1988; 116: 1542–51.CrossRefGoogle ScholarPubMed

78Kowey, PR, Stohler, JL, Friehling, TD, Marinchak, RA.Propafenone in the treatment of patients with malignant ventricular tachyarrhythmias. Can J Cardiol 1991; 7: 175–80.Google ScholarPubMed

79Gonzalez, R, Scheinman, MM, Herre, JM, Griffin, JC, Sauve, MJ, Sharkey, H.Usefulness of sotalol for drug-refractory malignant ventricular arrhythmias. Am Coll Cardiol 1988; 12: 1568–72.CrossRefGoogle ScholarPubMed

80Kehoe, RF, Zheutlin, TA, Dunnington, CS, Mattini, TA, Yu, G, Spangenberg, RB.Safety and efficacy of sotalol in patients with drug-refractory sustained ventricular tachyarrhythmias. Am J Cardiol 1990; 65: 58–64A.CrossRefGoogle ScholarPubMed

81Nademanee, K, Singh, BN, Hendrickson, J et al. Amodarone in refractory life-threatening ventricular arrhythmias. Ann Intern Med 1983; 98: 577–84.Google Scholar

82McGovern, B, Garan, H, Malacoff, RF et al. Long-term clinical outcome of ventricular tachycardia or fibrillation treated with amiodarone. Am J Cardiol 1984: 53: 1558–63.Google Scholar

83Kulbertus, HE, Deleval-Turren, F, Demoulin, JC.Sinoatrial disease: a report on 13 cases. J Electrocardiol 1973; 6: 303–12.CrossRefGoogle ScholarPubMed

84World Survey on Cardiac Pacing (1981). PACE 1983; 6: A157–172.Google Scholar

85Rokseth, R, Hattle, L.Sinus arrest in acute myocardial infarction. Br Heart J 1971; 33: 639–42.CrossRefGoogle ScholarPubMed

86Shaw, DB, Linker, NJ, Heaver, PA, Evans, I.Chronic sinoatrial disorder (sick sinus syndrome) a possible result of cardiac ischemia. Br Heart J 1987; 53: 598–607.CrossRefGoogle Scholar

87Jose, AD, Collison, D.The normal range and determinants of the intrinsic heart rate in man. Cardiovasc Res 1970; 4: 160–67.CrossRefGoogle ScholarPubMed

88Johnston, FA, Robinson, JF, Fyfe, T.Exercise testing in the diagnosis of sick sinus syndrome in the elderly: implications for treatment. PACE 1987; 10: 831–38.CrossRefGoogle ScholarPubMed

89Benditt, DG, Garnick, CC, Dunbar, D, Almquist, A, Pool-Schneider, S.Indications for electrophysiologic testing in the diagnosis and assessment of sinus node dysfunction. Circulation 1987; 75: (suppl 3, pt II): 11193–99.Google ScholarPubMed

90Cain, ME.Electrophysiologic assessment of sinus node function. Circulation 1987; 75: (suppl 3, pt II): III100–102.Google Scholar

91Yee, R, Strauss, HC.Electrophysiologic mechanisms: sinus node dysfunction. Circulation 1987; 75: (suppl 3, pt II): III12–18.Google ScholarPubMed

92Viersma, JW, Van Den Bers, MD, Van-Gilst, WH, Lie, KI.Intrinsic sympatholmimetic activity (ISA) of pindolol in patients with sinus node dysfunction. Eur Heart J 1986; 7: 42–46.CrossRefGoogle ScholarPubMed

93Lippestade, CT, Forfang, K.Production of sinus arrest by lignocaine. Br Med J 1971; 1: 537.CrossRefGoogle Scholar

94Lemke, B, Holtman, BJ, Selbach, H, Barmeyer, J.The atrial pacemaker: retrospective analysis of complications and life expectancy in patients with sinus node dysfunction. Int J Cardiol 1989; 22: 185–93.CrossRefGoogle ScholarPubMed

95Mitsuoka, T, Kenny, RA, Yeung, TA, Chan, SL, Perrins, JE, Sutton, R.Benefits of dual-chamber pacing in sick sinus syndrome. Br Heart J 1988; 60: 338–47.CrossRefGoogle ScholarPubMed

96Rediker, DE, Eagle, KA, Homma, S, Gillam, LD, Harthorne, JW.Clinical and hemodynamic comparison of WI versus DDD pacing in patients with DDD pacemakers. Am J Cardiol 1988; 61: 323–92.CrossRefGoogle Scholar

97Sasaki, Y, Shimotori, M, Akahane, K et al. Long-term follow-up of patients with sick sinus syndrome: a comparison of clinical aspects among unpaced, ventricular inhibited paced and physiologically paced groups. PACE 1988; 11: 1575–83.Google Scholar

98Morgan, JM, Joseph, SP, Bahri, AK, Ramdial, J, Crowthar, A.Choosing the pacemaker; a rational approach to the use of modern pacemaker technology. Ear Heart J 1990; 11: 753–64.CrossRefGoogle Scholar

99Breivik, K, Ohm, OJ, Segadal, L.Sick sinus syndrome treated with permanent pacemaker in 109 patients. A follow-up study. Acta Med Scand 1979; 206: 153–59.CrossRefGoogle ScholarPubMed

100Alt, E, Volker, R, Wirtzfeld, A, Ulm, K.Survival and follow-up after pacemaker implantation: a comparison of patients with sick sinus syndrome, complete heart block and atrial fibrillation. PACE 1985; 8: 849–55.CrossRefGoogle ScholarPubMed