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Are subjective cognitive complaints relevant in preclinical Alzheimer's disease? A review and guidelines for healthcare professionals

Published online by Cambridge University Press:  06 November 2012

Ruth E Mark  and
Margriet M Sitskoorn
Ruth E Mark*
Affiliation:
Department of Cognitive Neuropsychology, Tilburg University, The Netherlands
Margriet M Sitskoorn
Affiliation:
Department of Cognitive Neuropsychology, Tilburg University, The Netherlands
*
Address for correspondence: Ruth Elaine Mark, Department of Cognitive Neuropsychology, Tilburg University, Postbox 90153, 5000 LE Tilburg, The Netherlands. Email: [email protected]
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Summary

Identifying what makes people vulnerable to developing Alzheimer's disease (AD) is at the forefront of many research programmes, while early diagnosis is the goal in clinical practice. What individuals themselves tell their general practitioners (GPs) is clearly important because these subjective complaints may be a clue that something is wrong. More specifically, subjective cognitive complaints (SCC) may be the first sign of AD in individuals whose cognitive performance on standard neuropsychological tasks is normal for their age. The challenge for researchers in this field is twofold: (a) determining when SCC do or do not predict current cognitive functioning and future dementia; and (b) estimating how relevant they are for patients and their proxies. The current article addresses these issues, while guidelines are also provided in an attempt to help clinicians interpret and make treatment decisions about their patients’ SCC.

Keywords

subjective cognitive complaintsobjective cognitive performancemild cognitive impairmentAlzheimer's diseaserisk factorspredictor variables
Type
Neuropsychiatry of old age
Information
Reviews in Clinical Gerontology , Volume 23 , Issue 1 , February 2013 , pp. 61 - 74
Copyright
Copyright © Cambridge University Press 2012

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