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Alzheimer's disease: progress in pathological and aetiological aspects

Published online by Cambridge University Press:  17 November 2008

David MA Mann*
Affiliation:
University of Manchester, Manchester, UK
*
David MA Mann, Department of Pathological Sciences, Division of Molecular Pathology, University of Manchester, Manchester M13 9PT, UK.

Abstract

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Type
Psychiatry of old age
Copyright
Copyright © Cambridge University Press 1994

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References

1Mann, DMA, Yates, PO.Neurotransmitter deficits in Alzheimer's disease and other dementing disorders. Hum Neurobiol 1986; 5: 147–58.Google ScholarPubMed
2Wisniewski, HM, Terry, RD.Re-examination of the pathogenesis of the senile plaque. Prog Neuropathol 1973; 2: 126.Google Scholar
3Glenner, GG, Wong, CW.Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular protein. Biochem Biophys Res Commun 1984; 120: 885–90.CrossRefGoogle ScholarPubMed
4Masters, CL, Simms, GL, Weinmann, NA, Multhaup, G, McDonald, BL, Beyreuther, K.Amyloid plaque core protein in Alzheimer's disease and Down's syndrome. Proc Natl Acad Sci USA 1985; 85: 4245–49.CrossRefGoogle Scholar
5Joachim, CL, Duffy, LK, Morris, JH, Selkoe, DJ.Protein chemical and immunocytochemical studies of meningovascular amyloid protein in Alzheimer's disease and normal aging. Brain Res 1988; 474: 100–11.CrossRefGoogle ScholarPubMed
6Selkoe, DJ, Abraham, CR, Podlisny, MB, Duffy, LK.Isolation of low-molecular-weight proteins from amyloid plaque fibres in Alzheimer's disease. J Neurochem 1986; 46: 1820–34.CrossRefGoogle ScholarPubMed
7Ikeda, S-I, Allsop, D, Glenner, GG.The morphology and distribution of plaque and related deposits in the brains of Alzheimer's disease and control cases: an immunohistochemical study using amyloid β protein antibody. Lab Invest 1989; 60: 113–22.Google ScholarPubMed
8Ogomori, K, Kitamoto, T, Tateishi, J, Sato, Y, Suetsugu, M, Abe, M.β protein amyloid is widely distributed in the central nervous system of patients with Alzheimer's disease. Am J Pathol 1989; 134: 243–51.Google ScholarPubMed
9Joachim, CL, Morris, JH, Selkoe, DJ.Diffuse amyloid plaques occur commonly in the cerebellum in Alzheimer's disease. Am J Pathol 1989; 135: 309–19.Google ScholarPubMed
10Mann, DMA, Jones, D, Prinja, D, Purkiss, MS.The prevalence of amyloid (A4) protein deposits within the cerebral and cerebellar cortex in Down's syndrome and Alzheimer's disease. Acta Neuropathol 1990; 80: 318–27.CrossRefGoogle ScholarPubMed
11Wisniewski, HM, Bancher, C, Barcikowska, M, Wen, GY, Currie, J.Spectrum of morphological appearance of amyloid deposits in Alzheimer's disease. Acta Neuropathol 1989; 78: 337–47.CrossRefGoogle ScholarPubMed
12Yamaguchi, H, Hirai, S, Morimatsu, M, Shoji, M, Ihara, Y.A variety of cerebral amyloid deposits in the brains of Alzheimer-type dementia demonstrated by β-protein immunostaining. Acta Neuropathol 1988; 76: 541–49.CrossRefGoogle ScholarPubMed
13Yamaguchi, H, Hirai, S, Morimatsu, M, Shoji, M, Nakazato, Y.Diffuse type of senile plaques in the cerebellum of Alzheimer-type dementia detected by β-protein immunostaining. Acta Neuropathol 1989; 77: 314–19.CrossRefGoogle Scholar
14Suenaga, T, Hirano, A, Llena, JF, Yen, S-H, Dickson, DW.Modified Bielschowsky staining andimmunohistochemical studies on striatal plaques in Alzheimer's disease. Acta Neuropathol 1990; 80: 280–86.CrossRefGoogle Scholar
15Powers, JM, Skeen, JT.Ultrastructural heterogeneity in cerebral amyloid of Alzheimer's disease. Acta Neuropathol 1988; 76: 613–23.CrossRefGoogle ScholarPubMed
16Davies, CA, Mann, DMA.Is the ‘preamyloid’ of diffuse plaques of Alzheimer's disease really non-fibrillar. Am J Pathol 1993 (in press).Google Scholar
17Duckett, S, Galle, P.Mise en évidence de l'aluminium dans les plaques séniles de la maladie d' Alzheimer, étude à la microsonde de Castaing. C R Acad Sci 1976; 282: 393–95.Google Scholar
18Candy, JM, Oakley, AE, Klinowski, J et al. Aluminiosilicates and senile plaque formation in Alzheimer's disease. Lancet 1986; i: 354–57.CrossRefGoogle Scholar
19Chafi, AH, Hauw, J-J, Rancurel, G, Berry, J-P, Galle, C.Absence of aluminium in Alzheimer's disease brain tissue: electron microprobe and ion microprobe studies. Neurosci Lett 1991; 123: 6164.CrossRefGoogle ScholarPubMed
20Landsberg, JP, McDonald, B, Watt, JF.Absence of aluminium in neuritic plaque cores in Alzheimer's disease. Nature 1992; 360: 6568.CrossRefGoogle ScholarPubMed
21Snow, AD, Mar, H, Nochlin, D et al. Early accumulation of heparan sulphate in neurones and in the β-amyloid protein containing lesions of Alzheimer's disease and Down's syndrome. Am J Pathol 1990; 137: 1253–70.Google ScholarPubMed
22Mann, DMA, Brown, AMT, Prinja, D et al. An analysis of the morphology of senile plaques in Down's syndrome patients of different ages using immunocytochemical and lectin histochemical techniques. Neuropathol Appl Neurobiol 1989; 15: 317–29.CrossRefGoogle ScholarPubMed
23Kang, J, Lemaire, H-G, Unterbeck, A et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell surface receptor. Nature 1987; 326: 733–36.CrossRefGoogle Scholar
24Kitaguchi, N, Takahashi, Y, Tokushima, Y, Shiojiri, S, Ito, H.Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity. Nature 1988; 331: 530–32.CrossRefGoogle ScholarPubMed
25Ponte, P, Gonzalez De Whitt, P, Schilling, J et al. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature 1988; 331: 525–27.CrossRefGoogle ScholarPubMed
26Tanzi, RE, McClatchey, AI, Lamperti, ED, Villa-Komaroff, L, Gusella, JF, Neve, RL.Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease. Nature 1988; 331: 528–30.CrossRefGoogle ScholarPubMed
27Bahmanyar, S, Higgins, GA, Goldgaber, D et al. Localization of amyloid β protein messenger RNA in brains from patients with Alzheimer's disease. Science 1987; 237: 7780.CrossRefGoogle ScholarPubMed
28Goedert, M.Neuronal localization of amyloid β protein precursor mRNA in normal human brains and in Alzheimer's disease. EMBO J 1987; 6: 3627–32.CrossRefGoogle ScholarPubMed
29Shivers, BD, Hilbich, C, Multhaup, G, Salbaum, JM, Beyreuther, K, Seeburg, PH.Alzheimer's disease amyloidogenic glycoprotein expression pattern in rat brain suggests a role in cell contact. EMBO J 1988; 7: 1365–70.CrossRefGoogle ScholarPubMed
30Mita, S, Schon, EA, Herbert, J.Widespread expression of amyloid β protein precursor gene in rat brain. Am J Pathol 1989; 134: 1253–61.Google ScholarPubMed
31Johnson, SA, McNeill, T, Cordell, B, Finch, CE.Relationship of neuronal APP751/APP695 mRNA ratios to neuritic plaque density in Alzheimer's disease. Science 1990; 248: 854–57.CrossRefGoogle Scholar
32Card, JP, Meade, RP, Davis, LG.Immunocytochemical localization of the precursor protein for β-amyloid in the rat central nervous system. Neuron 1988; 1: 835–46.CrossRefGoogle ScholarPubMed
33Cras, P, Kawai, M, Siedlak, S et al. Neuronal and microglial involvement in β-amyloid protein deposition in Alzheimer's disease. Am J Pathol 1990; 137: 241–46.Google ScholarPubMed
34Arai, H, Lee, VM-Y, Messinger, ML et al. Expression patterns of β-amyloid precursor protein (β-APP) in neural and non neural human tissues from Alzheimer's disease and control subjects. Ann Neurol 1991; 30: 686–93.CrossRefGoogle ScholarPubMed
35Cummings, BJ, Su, JM, Geddes, JW et al. Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in Alzheimer's disease. Neuroscience 1992; 48: 763–77.CrossRefGoogle ScholarPubMed
36Ohyagi, Y, Takahashi, K, Satoh, Y, Makifuchi, T, Tabira, T.Cerebral cortical amyloid protein precursor mRNA expression is similar in Alzheimer's disease and other neurodegenerative diseases. J Neurol Sci 1991; 111: 3338.CrossRefGoogle Scholar
37Stern, RA, Otvos, L, Trojanowski, JQ, Lee, VM-Y.Monoclonal antibodies to a synthetic peptide homologous with the first 28 amino acids of Alzheimer's disease β protein recognize amyloid and diverse glial and neuronal cell types in the central nervous system. Am J Pathol 1989; 134: 973–78.Google ScholarPubMed
38Haass, C, Hung, AY, Selkoe, DJ.Processing of β-amyloid precursor protein in microglia and astrocytes favours an internal localization over constitutive secretion. J Neurosci 1991; 11: 3783–93.CrossRefGoogle ScholarPubMed
39Siman, RL, Card, JP, Welson, RB, Davis, LG.Expression of β-amyloid precursor protein in reactive astrocytes following neuronal damage. Neuron 1989; 3: 275–85.CrossRefGoogle ScholarPubMed
40Shigematsu, K, McGeer, PL.Accumulation of amyloid precursor protein in damaged neuronalprocesses and microglia following intracerebral administration of aluminium salts. Brain Res 1992; 593: 117–23.CrossRefGoogle Scholar
41Shigematsu, K, McGeer, PL.Accumulation of amyloid precursor protein in neurones after intraventricular injection of colchicine. Am J Pathol 1992; 140: 787–94.Google ScholarPubMed
42Kawarabayashi, T, Shoji, M, Harigaya, Y, Yamaguchi, H, Hirai, S.Expression of APP in early stages of brain damage. Brain Res 1991; 563: 334–38.CrossRefGoogle ScholarPubMed
43Kalaria, RN, Bhatti, SU, Palatinsky, EA et al. Accumulation of β-amyloid precursor protein at sites of ischemie injury in rat brain. Neuroreport 1993 (in press).CrossRefGoogle Scholar
44Koo, EH, Sisodia, SS, Archer, DR et al. Precursor of amyloid protein in Alzheimer's disease undergoes fast anterograde axonal transport. Proc Natl Acad Sci USA 1990; 87: 1561–65.CrossRefGoogle ScholarPubMed
45Shigematsu, K, McGeer, PL, McGeer, EG.Localization of amyloid precursor protein in selective postsynaptic densities of rat cortical neurones. Brain Res 1992; 592: 353–57.CrossRefGoogle Scholar
46Schubert, W, Prior, R, Weidemann, A et al. Localization of Alzheimer β/A4 amyloid precursor protein at central and peripheral sites. Brain Res 1991; 563: 184–94.CrossRefGoogle Scholar
47Esch, FS, Keim, PS, Beattie, EC et al. Cleavage of amyloid β peptide during constitutive processing of its precursor. Science 1990; 248: 1122–24.CrossRefGoogle ScholarPubMed
48Sisodia, SS, Koo, EH, Beyreuther, K, Unterbeck, A, Price, DL.Evidence that β amyloid protein in Alzheimer's disease is not derived by normal processing. Science 1990; 248: 492–95.CrossRefGoogle Scholar
49Anderson, JP, Esch, FS, Keim, PS, Sambamurti, K, Lieberburg, I, Robakis, NK.Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells. Neurosci Lett 1991; 128: 126–28.CrossRefGoogle ScholarPubMed
50Palmert, MR, Podlisny, MB, Witker, DS et al. The beta-amyloid protein precursor of Alzheimer's disease has soluble derivatives found in human brain and cerebrospinal fluid. Proc Natl Acad Sci USA 1989; 86: 6338–42.CrossRefGoogle ScholarPubMed
51Weidemann, A, Konig, G, Bunke, D et al. Identification, biogenesis and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell 1989; 57: 115–26.CrossRefGoogle ScholarPubMed
52Podlisny, MB, Mammen, AL, Schlossmacher, MG, Palmert, MR, Younkin, SG, Selkoe, DJ.Detection of soluble forms of the β amyloid precursor protein in human plasma. Biochem Biophys Res Commun 1990; 167: 1094–101.CrossRefGoogle ScholarPubMed
53Oltersdorf, T, Fritz, LC, Schenk, DG et al. The secreted form of the Alzheimer amyloid precursor protein with the Kunitz domain is protease nexin II. Nature 1989; 341: 144–47.CrossRefGoogle ScholarPubMed
54Van Nostrand, WE, Wagner, SL, Suzuki, M et al. Protease nexin-II, a potent anti-chymotrypsin, shows identity to amyloid β protein precursor. Nature 1989; 341: 546–49.CrossRefGoogle Scholar
55Busciglio, J, Gabuzda, DH, Matsudaira, P, Yankner, BA.Generation of β-amyloid in the secretory pathway in neuronal and non-neuronal cells. Proc Natl Acad Sci USA 1993; 90: 2092–96.CrossRefGoogle Scholar
56Sisodia, SS.β-amyloid precursor protein cleavage by a membrane-bound protease. Proc Natl Acad Sci USA 1992; 89: 6075–79.CrossRefGoogle ScholarPubMed
57Maruyama, K, Kametani, F, Usami, M, Yamao-Harigaya, W, Tanaka, K.‘Secretase’, Alzheimer amyloid precursor protein secreting enzyme is not sequence specific. Biochem Biophys Res Commun 1991; 179: 1670–76.CrossRefGoogle Scholar
58Oltersdorf, T, Ward, PJ, Beattie, EC, Blakeley, M, Fritz, LC, Lieberburg, I.In vitro mutagenesis of the β-amyloid precursor protein. Neurobiol Ageing 1990; 11: 219.Google Scholar
59Caporaso, GL, Gandy, SE, Buxbaum, JD, Ramabhadran, TV, Greengard, P.Protein phosphorylation regulates secretion of Alzheimer β/A4 amyloid precursor protein. Proc Natl Acad Sci USA 1992; 89: 3055–59.CrossRefGoogle ScholarPubMed
60Buxbaum, JD, Oishi, M, Chen, HI et al. Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer β/A4 amyloid precursor protein. Proc Natl Acad Sci USA 1992; 89: 10075–78.CrossRefGoogle Scholar
61Nitsch, RM, Slack, BE, Wurtman, RJ, Growdon, JH.Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science 1992; 258: 304307.CrossRefGoogle ScholarPubMed
62Kennedy, H, Kametani, K, Allsop, D.Only Kunitz inhibitor-containing isoforms of secreted Alzheimer amyloid precursor protein show amyloid immunoreactivity in normal cerebrospinal fluid. Neurodegeneration 1992; 1: 5964.Google Scholar
63Seubert, P, Oltersdorf, T, Lee, MG et al. Secretion of β-amyloid precursor protein cleaved at the aminoterminus of the β-amyloid peptide. Nature 1992; 361: 260–63.CrossRefGoogle Scholar
64Estus, S, Golde, TE, Kunishita, T et al. Potentially amyloidogenic carboxy-terminal derivatives of the amyloid protein precursor. Science 1992; 255: 726–28.CrossRefGoogle Scholar
65Golde, TE, Estus, S, Younkin, LH, Selkoe, DJ, Younkin, SG.Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science 1992; 155: 728–30.CrossRefGoogle Scholar
66Haass, C, Koo, EH, Mellon, A, Hung, AY, Selkoe, DJ.Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid bearing fragments. Nature 1992; 357: 500502.CrossRefGoogle ScholarPubMed
67Knops, J, Lieberburg, I, Sinha, S.Evidence for a nonsecretory, acidic degradation pathway for amyloid precursor protein in 293 cells. J Biol Chem 1992; 267: 16022–24.CrossRefGoogle ScholarPubMed
68Davis, D, Sinha, S, Schlossmacher, MG et al. Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids. Nature 1992; 359: 325–27.Google Scholar
69Haass, C, Schlossmacher, MG, Hung, Y et al. Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature 1992; 359: 322–25.CrossRefGoogle ScholarPubMed
70Shoji, M, Golde, TE, Ghiso, J et al. Production of Alzheimer amyloid β protein by normal proteolytic processing. Science 1992; 258: 126–29.CrossRefGoogle ScholarPubMed
71Tagliavini, F, Ghiso, J, Timmers, WF, Giaccone, G, Bugiani, O, Frangione, B.Co-existence of Alzheimer amyloid precursor protein and amyloid protein in cerebral vessel walls. Lab Invest 1990; 62: 791–97.Google Scholar
72Ko, L, Sheu, K-FR, Blass, JP.Immunohistochemical co-localization of amyloid precursor protein with cerebrovascular amyloid of Alzheimer's disease. Am J Pathol 1991; 139: 523–33.Google Scholar
73Shoji, M, Hirai, S, Harigaya, Y, Kawarabayashi, T, Yamaguchi, H.The amyloid β precursor protein is localized in smooth muscle cells of leptomeningeal vessels. Brain Res 1990; 530: 113–16.CrossRefGoogle ScholarPubMed
74Kawai, M, Kalaria, RN, Cras, P et al. Degeneration of amyloid precursor protein containihng smooth muscle cells in cerebral amyloid angiopathy. Brain Res 1993 (in press).Google Scholar
75Yamaguchi, H, Yamazaki, T, Lemere, CA, Frosch, MP, Selko, DJ.Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. Am J Pathol 1992; 141: 249–59.Google ScholarPubMed
76Perlmutter, LS, Barron, E, Chui, HC.Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease. Neurosci Lett 1990; 119: 3236.CrossRefGoogle ScholarPubMed
77Wegiel, J, Wisniewski, HM.The complex of microglial cells and amyloid star in three-dimensional reconstruction. Acta Neuropathol 1990; 81: 116–24.CrossRefGoogle ScholarPubMed
78McGeer, PL, Akiyama, H, Kawamata, T, Yamada, T, Walker, DG, Ishii, T.Immunohistochemical localization of β-amyloid precursor protein sequences in Alzheimer and normal brain tissue by light and electron microscopy. J Neurosci Res 1992; 31: 428–42.CrossRefGoogle ScholarPubMed
79Wisniewski, HM, Wegiel, J, Wang, KC, Lach, B.Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease. Acta Neuropathol 1992; 84: 117–27.CrossRefGoogle ScholarPubMed
80Mann, DMA, Younis, N, Jones, D, Stoddart, RW.The time course of pathological events in Down's syndrome with particular reference to the involvement of microglial cells and deposits of β/A4. Neurodegeneration 1992; 1: 201–15.Google Scholar
81Murphy, GM, Eng, LF, Ellis, WG, Perry, G, Meissner, LC, Tinklenberg, JR.Antigenic profile of plaques and neurofibrillary tangles in the amygdala in Down's syndrome: a comparison with Alzheimer's disease. Brain Res 1990; 537: 102108.CrossRefGoogle ScholarPubMed
82Allsop, D, Haga, S-I, Haga, C, Ikeda, S-I, Mann, DMA, Ishii, T.Early senile plaques in Down's syndrome brains show a close relationship with cell bodies of neurones. Neuropathol Appl Neurobiol 1989; 15: 531–42.CrossRefGoogle Scholar
83Mann, DMA, Brown, AMT, Prinja, D, Jones, D, Davies, CA.A morphological analysis of senile plaques in the brains of non-demented persons of different ages using silver, immunocytochemical and lectin histochemical staining techniques. Neuropathol Appl Neurobiol 1990; 16: 1725.CrossRefGoogle ScholarPubMed
84Ohgami, T, Kitamoto, T, Shin, R-W, Kaneko, Y, Ogomori, K, Tateishi, J.Increased senile plaques without microglia in Alzheimer's disease. Acta Neuropathol 1991; 81: 242–47.CrossRefGoogle ScholarPubMed
85Rozemuller, JM, Bots, GTAM, Roos, RAC, Eikelenboom, P.Acute phase proteins but not activated microglial cells are present in parenchymal β/A4 deposits in the brains of patients with hereditary cerebral haemorrhage with amyloidosis-Dutch type. Neurosci Lett 1992; 140: 137–40.CrossRefGoogle ScholarPubMed
86Shigematsu, K, McGeer, PL, Walker, DG, Ishii, T, McGeer, EG.Reactive microglia phagocytose amyloid precursor protein produced by neurones following neural damage. J Neurosci Res 1992; 31: 443–53.CrossRefGoogle ScholarPubMed
87Araujo, DM, Cotman, CW.Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease. Brain Res 1992; 569: 141–45.CrossRefGoogle ScholarPubMed
88Giulian, D, Woodward, J, Young, DG, Krebs, JF, Lachman, LB.Interleukin l injected into mammalian brain stimulates astrogliosis and neovascularization. J Neurosci 1988; 8: 2485–90.CrossRefGoogle Scholar
89Probst, A, Langui, D, Ipsen, S, Robakis, NK, Ulrich, J.Deposition of β/A4 protein along neuronal plasma membranes in diffuse senile plaques. Acta Neuropathol 1991; 83: 2129.CrossRefGoogle ScholarPubMed
90Pappolla, MA, Omar, RA, Sambamurti, K, Anderson, JP, Robakis, NK.The genesis of the senile plaque. Further evidence in support of its neuronal origin. Am J Pathol 1992; 141: 1151–59.Google ScholarPubMed
91Cras, P, Kawai, M, Lowery, DE, Gonzalez-de Whitt, P, Greenberg, B, Perry, G.Senile plaque neurites in Alzheimer's disease accumulate amyloid precursor protein. Proc Natl Acad Sci 1991; 88: 7552–56.CrossRefGoogle ScholarPubMed
92Shoji, M, Hirai, S, Yamaguchi, H, Harigaya, Y, Kawarabayashi, T.Amyloid β-protein precursor accumulates in dystrophic neurites of senile plaques in Alzheimer's disease. Brain Res 1990; 512: 164–68.CrossRefGoogle Scholar
93Tate-Ostroff, B, Majocha, Re, Marotta, CA.Identification of cellular and extracellular sites of amyloid precursor protein extracytoplasmic domain in normal and Alzheimer's disease brains. Proc Natl Acad Sci USA 1989; 86: 745–49.CrossRefGoogle Scholar
94Joachim, CL, Games, D, Morris, J, Ward, P, Frenkel, D, Selkoe, D.Antibodies to non-Beta regiosn of the beta-amyloid precursor protein detect a subset of plaques. Am J Pathol 1991; 138: 373–84.Google Scholar
95Kawai, M, Cras, P, Richey, P et al. Subcellular localization of amyloid precursor protein in senile plaques of Alzheimer's disease. Am J Pathol 1992; 140: 947–58.Google ScholarPubMed
96Ohgami, T, Kitamoto, T, Weidemann, A, Beyreuther, K, Tateishi, J.Alzheimer amyloid precursor protein-positive degenerative neurites exist even within Kuru plaques not specific to Alzheimer's disease. Am J Pathol 1991; 139: 1245–50.Google Scholar
97Ohgami, T, Kitamoto, T, Tateishi, J.Alzheimer amyloid precursor protein accumulates within axonal swellings in human brain lesions. Neurosci Lett 1992; 136: 7578.CrossRefGoogle ScholarPubMed
98Cochran, E, Bacci, B, Chen, Y, Patton, A, Gambetti, P, Autilio-Gambetti, L.Amyloid precursor protein and ubiquitin immunoreactivity in dystrophic axons is not unique to Alzheimer's disease. Am J Pathol 1991; 139: 485–89.Google Scholar
99Mann, DMA, Jones, D.Deposition of amyloid (A4) protein within the brains of persons with dementing disorders other than Alzheimer's disease and Down's syndrome. Neurosci Lett 1990; 109: 6875.CrossRefGoogle ScholarPubMed
100Mann, DMA, Jones, D, South, PW, Snowden, JS, Neary, D.Deposition of amyloid β protein in non-Alzheimer dementias: Evidence for a neuronal origin of parenchymal deposits of β protein in neurodegenerative disease. Acta Neuropathol 1992; 83: 415–19.CrossRefGoogle ScholarPubMed
101Tan, N, Mastaglia, F, Masters, CL, Beyreuther, K, Kakulas, BA.Amyloid (A4) protein deposition in brain in progressive supranuclear palsy (PSP). Alzheimer Dis Assoc Disord 1988; 2: 264.CrossRefGoogle Scholar
102Mastaglia, FL, Masters, CL, Beyreuther, K, Kakulas, BA.Deposition of amyloid (A4) protein in the cerebral cortex in Parkinson's disease (PD). Alzheimer Dis Assoc Disord 1988; 2: 245.CrossRefGoogle Scholar
103Dickson, DW, Ruan, D, Crystal, H et al. Hippocampal degeneration differentiates diffuse Lewy body disease (DLDB) from Alzheimer's disease: light and electron microscopic immunocytochemistry of CA2–3 neurites specific to DLDB. Neurology 1991; 41: 1402–409.CrossRefGoogle Scholar
104Candy, JM, McArthur, FK, Oakley, AE et al. Aluminium accumulation in relation to senile plaque and neurofibrillary tangle formation in the brains of patients with renal failure. J Neurol Sci 1992; 107: 210–18.CrossRefGoogle ScholarPubMed
105Roberts, GW, Gentleman, SM, Lynch, A, Graham, D.β/A4 amyloid protein deposition in brain after head trauma. Lancet 1991; 338: 1422–23.CrossRefGoogle ScholarPubMed
106Trojanowski, JQ, Schmidt, ML, Shin, R-W, Bramblett, GT, Rao, D, Lee, VM-Y.Altered tau and neurofilament proteins in neurodegenerative diseases: diagnostic implications for Alzheimer's disease and Lewy body dementia. Brain Pathol 1993; 3: 4554.CrossRefGoogle Scholar
107Tabaton, M, Cammarata, S, Mandybur, T et al. Senile plaques in cerebral amyloid angiopathy show accumulation of amyloid precursor protein without cytoskeletal abnormalities. Brain Res 1992; 593: 299303.CrossRefGoogle ScholarPubMed
108Maat-Schieman, MLC, Van Duinen, SG, Haan, J, Roos, RAC.Morphology of cerebral plaque-like lesions in hereditary cerebral haemorrhage with amyloidosis (Dutch). Acta Neuropathol 1992; 84: 674–79.CrossRefGoogle Scholar
109Hendriks, L, Van Duijn, CM, Cras, P et al. Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β-amyloid percursor protein gene. Nature Genet 1992; 1: 218–21.CrossRefGoogle Scholar
110Levy, E, Carman, MD, Fernandez-Madrid, IJ et al. Mutation of the Alzheimer's disease, amyloid gene in hereditary cerebral haemorrhage, Dutch-type. Science 1990; 248: 1124–26.CrossRefGoogle ScholarPubMed
111Fernandez-Madrid, I, Levy, E, Marder, K, Frangione, B.Codon 618 variant of Alzheimer amyloid gene associated with inherited cerebral haemorrhage. Ann Neurol 1991; 30: 730–33.CrossRefGoogle Scholar
112Crowther, RA.Straight and paired helical filaments in Alzheimer's disease have a common structural unit. Proc Natl Acad Sci USA 1991; 88: 2288–92.CrossRefGoogle ScholarPubMed
113Wischik, CM, Novak, M, Thogerson, HC et al. Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer's disease. Proc Natl Acad Sci USA 1988; 85: 4506–10.CrossRefGoogle Scholar
114Wischik, CM, Novak, M, Edwards, PC, Klug, A, Tichelaar, RW, Crowther, RA.Structural characterization of the core of the paired helical filament of Alzheimer's disease. Proc Natl Acad Sci USA 1988; 85: 4884–88.CrossRefGoogle Scholar
115Kosik, KS.The molecular and cellular pathology of Alzheimer neurofibrillary lesions. J Gerontol 1989; 44: B55–B58.CrossRefGoogle ScholarPubMed
116Goedert, M, Spillantini, MG, Jakes, R, Rutherford, D, Crowther, RA.Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron 1989; 3: 519–26.CrossRefGoogle ScholarPubMed
117Kowall, KW, Kosik, KS.Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease. Ann Neurol 1987; 22: 639–43.CrossRefGoogle ScholarPubMed
118Mercken, M, Vandermeeren, M, Lubke, U et al. Monoclonal antibodies with selective specificity for Alzheimer tau are directed against phosphatase-sensitive epitopes. Acta Neuropathol 1992; 84: 265–72.CrossRefGoogle ScholarPubMed
119Dickson, DW, Ksiezak-Reding, H, Liu, W-K, Davies, P, Crowe, A, Yen, S-HC.Immunocytochemistry of neurofibrillary tangles with antibodies to subregions of tau protein: Identification of hidden and cleaved tau epitopes and a new phosphorylation site. Acta Neuropathol 1992; 84: 596605.CrossRefGoogle Scholar
120Vincent, IJ, Davies, P.A protein kinase associated with paired helical filaments in Alzheimer's disease. Proc Natl Acad Sci USA 1992; 89: 2878–82.CrossRefGoogle Scholar
121Wille, H, Drewes, G, Biernat, J, Mandelkow, E-M, Mandelkow, E.Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro. J Cell Biol 1992; 118: 573–84.CrossRefGoogle ScholarPubMed
122Crowther, RA, Olesen, OF, Jakes, R, Goedert, M.The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease. FEBS Lett 1992; 309: 199202.CrossRefGoogle ScholarPubMed
123Lowe, J, Mayer, RJ, Landon, M.Ubiquitin in neurodegenerative diseases. Brain Pathol 1993; 3: 5565.CrossRefGoogle ScholarPubMed
124Perry, G, Siedlak, SL, Richey, P et al. Association of heparan sulphate proteoglycan with the neurofibrillary tangles of Alzheimer's disease. J Neurosci 1991; 11: 3679–83.CrossRefGoogle ScholarPubMed
125Mann, DMA, Bonshek, RE, Marcyniuk, B, Stoddart, RW, Torgersen, E.Saccharides of senile plaques and neurofibrillary tangles in Alzheimer's disease. Neurosci Lett 1988; 85: 277–82.CrossRefGoogle ScholarPubMed
126Kosik, KS, Crandall, JE, Mufson, EJ, Neve, RL.Tau in situ hybridization in normal and Alzheimer brain: localization in the somatodendritic compartment. Ann Neurol 1989; 26: 352–61.CrossRefGoogle ScholarPubMed
127Sumpter, PQ, Mann, DMA, Davis, CA, Yates, PO, Snowden, JS, Neary, D.An ultrastructural analysis of the effects of accumulation of neurofibrillary tangle in pyramidal cells of the cerebral cortex in Alzheimer's disease. Neuropath Appl Neurobiol 1986; 12: 305–19.CrossRefGoogle ScholarPubMed
128Cras, P, Kawai, M, Siedlak, S, Perry, G.Microglia are associated with the extra cellular neurofibrillary tangles of Alzheimer's disease. Brain Res 1991; 558: 312–14.CrossRefGoogle Scholar
129Ikeda, K, Akiyama, M, Haga, C, Haga, S.Evidence that neurofibrillary tangles undergo glial modification. Acta Neuropathol 1992; 85: 101104.CrossRefGoogle ScholarPubMed
130Mann, DMA, Prinja, D, Davies, CA et al. Immunocytochemical profile of neurofibrillary tangles in Down's syndrome patients of different ages. J Neurol Sci 1989; 92: 247–60.CrossRefGoogle ScholarPubMed
131Bondareff, W, Wischik, CM, Novak, M, Amos, WB, Klug, A, Roth, M.Molecular analysis of neurofibrillary degeneration in Alzheimer's disease: an immunohistochemical study. Am J Pathol 1990; 137: 711–23.Google ScholarPubMed
132Tabaton, M, Cammarata, S, Mancardi, G et al. Ultrastructural localization of β-amyloid, tau and ubiquitin epitopes in extracellular neurofibrillary tangles. Proc Natl Acad Sci USA 1991; 88: 2098–102.CrossRefGoogle ScholarPubMed
133Yamaguchi, H, Nakazato, Y, Kawarabayashi, T et al. Extracellular neurofibrillary tangles associated with degenerating neurites and neuropil threads in Alzheimer-type dementia. Acta Neuropathol 1991; 81: 603609.CrossRefGoogle ScholarPubMed
134Endoh, R, Ogawara, M, Iwatsubo, T, Nakano, I, Mori, H.Lack of carboxyl terminal sequence of tau in ghost tangles of Alzheimer's disease. Brain Res 1993; 601: 164–72.CrossRefGoogle ScholarPubMed
135Blessed, G, Tomlinson, BE, Roth, M.The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiat 1968; 114: 797811.CrossRefGoogle ScholarPubMed
136McKee, AC, Kosik, KS, Kowall, NW.Neuritic pathology and dementia in Alzheimer's disease. Ann Neurol 1991; 30: 156–65.CrossRefGoogle ScholarPubMed
137Arriagada, PV, Growdon, JH, Hedley-White, ET, Hyman, BT.Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 1992; 42: 631–39.CrossRefGoogle ScholarPubMed
138Neary, D, Snowden, JS, Mann, DMA et al. Alzheimer's disease: a correlative study. J Neurol Neurosurg Psychiat 1986; 49: 229–37.CrossRefGoogle ScholarPubMed
139Van Nostrand, WE, Wagner, SL, Shankle, WR et al. Decreased levels of soluble amyloid β protein precursor in cerebrospinal fluid of live Alzheimer's disease patients. Proc Natl Acad Sci USA 1992; 89: 2551–55.CrossRefGoogle Scholar
140Farlow, M, Ghetti, B, Benson, MD et al. Low cerebrospinal-fluid concentrations of soluble amyloid β-protein precursor in hereditary Alzheimer's disease. Lancet 1992; 340: 453–54.CrossRefGoogle ScholarPubMed
141Francis, PT, Webster, M-T, Procter, AW et al. Soluble β-amyloid precursor protein and pyramidal neuron loss. Lancet 1993; 341: 431.CrossRefGoogle ScholarPubMed
142Wang, GP, Iqbal, K, Bucht, G, Winblad, B, Wisniewski, HM, Grundke-Iqbal, I.Alzheimer's disease: paired helical filament immunoreactivity in cerebrospinal fluid. Acta Neuropathol 1991; 82: 612.CrossRefGoogle ScholarPubMed
143Davies, CA, Mann, DMA, Sumpter, PQ, Yates, P.A quantitative analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease. J Neurol Sci 1987; 78: 151–64.CrossRefGoogle ScholarPubMed
144Terry, Rd, Masliah, E, Salmon, P et al. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 1991; 30: 572–80.CrossRefGoogle ScholarPubMed
145De Kosky, ST, Scheff, SW.Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann Neurol 1990; 27: 457–64.CrossRefGoogle ScholarPubMed
146Scheff, SW, Price, DA.Synapse loss in the temporal lobe in Alzheimer's disease. Ann Neurol 1993; 33: 190–99.CrossRefGoogle ScholarPubMed
147De Kosky, ST, Harbaugh, RE, Schmitt, FA et al. Cortical biopsy in Alzheimer's disease: diagnostic accuracy and neurochemical, neuropathological and cognitive correlations. Ann Neurol 1992; 32: 625–32.CrossRefGoogle ScholarPubMed
148Mann, DMA, Marcyniuk, B, Yates, PO, Neary, D, Snowden, JS.The progression of the pathological changes of Alzheimer's disease in frontal and temporal neocortex examined both in biopsy and at autopsy. Neuropathol Appl Neurobiol 1988; 14: 177–95.CrossRefGoogle ScholarPubMed
149Goate, A, Chartier-Harlin, M-C, Mullan, M et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991; 349: 704706.CrossRefGoogle ScholarPubMed
150Chartier-Harlin, M-C, Crawford, F, Houlden, H et al. Early onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene. Nature 1991; 353: 844–45.CrossRefGoogle ScholarPubMed
151Murrell, J, Farlow, M, Ghetti, B, Benson, MD.A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease patients. Science 1991; 254: 9799.CrossRefGoogle Scholar
152Naruse, S, Igarashi, S, Aoki, K et al. Missense mutation val → ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease. Lancet 1991; 337: 978–79.CrossRefGoogle ScholarPubMed
153Karlinsky, H, Vaula, G, Haines, JL et al. Molecular and prospective phenotypic characterization of a pedigree with familial Alzheimer's disease and a missense mutation in codon 717 of the β-amyloid precursor protein gene. Neurology 1992; 42: 1445–53.CrossRefGoogle Scholar
154Mullan, M, Crawford, F, Axelman, K et al. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of β-amyloid. Nature Genet 1992; 1: 345–47.CrossRefGoogle ScholarPubMed
155Adroer, R, Lopez-Acedo, C, Oliva, R, Hardy, J, Fidani, L.A novel silent variant at codon 711 and a variant at codon 708 of the APP sequence detected in Spanish Alzheimer and control cases. Neurosci Lett 1993; 150: 3334.CrossRefGoogle Scholar
156Balbin, M, Abrahamson, M, Gustafson, L, Nilsson, K, Brun, A.A novel mutation in the β-protein coding region of the amyloid β-protein precursor (APP) gene. Hum Genet 1992; 89: 580–82.CrossRefGoogle ScholarPubMed
157Lantos, P, Luthert, PJ, Hanger, D, Anderton, BH, Mullan, M, Rossor, M.Familial Alzheimer's disease with the amyloid precursor protein position 717 mutation and sporadic Alzheimer's disease have the same cytoskeletal pathology. Neurosci Lett 1992; 137: 221–24.CrossRefGoogle ScholarPubMed
158Mann, DMA, Jones, D, Snowden, JS, Neary, D, Hardy, J.Pathological changes in the brain of a patient with familial Alzheimer's disease having a missense mutation at codon 717 in the amyloid precursor protein gene. Neurosci Lett 1992; 137: 225–28.CrossRefGoogle ScholarPubMed
159Cairns, NJ, Chadwick, A, Lantos, PL, Levy, R, Rossor, MN.β/A4 protein deposition in familial Alzheimer's disease with the mutation in codon of the β/A4 amyloid precursor protein gene and sporadic Alzheimer's disease. Neurosci Lett 1993; 149: 137–40.CrossRefGoogle ScholarPubMed
160Ghetti, B, Murrell, J, Benson, MD, Farlow, MR.Spectrum of amyloid β-protein immunoreactivity in hereditary Alzheimer's disease with a guanine to thymine missense change at position 1924 of the APP gene. Brain Res 1992; 571: 133–39.CrossRefGoogle ScholarPubMed
161StGeorge-Hyslop, PM, Haines, JL, Fairer, LA et al. Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. Nature 1990; 347: 194–97.CrossRefGoogle Scholar
162Schellenberg, GD, Bird, TD, Wijsman, E et al. Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science 1992; 258: 668–71.CrossRefGoogle ScholarPubMed
163Mullan, M, Houlden, H, Windelspecht, M et al. A major locus for familial early onset Alzheimer's disease is on the long arm of chromosome 14, proximal to antichymotrypsin. Nature Genet 1992; 2: 340430.CrossRefGoogle Scholar
164Pericak-Vance, MA, Bebout, JL, Gaskell, PC et al. Linkage studies in familial Alzheimer's disease: evidence for chromosome 19 linkage. Am J Hum Genet 1991; 48: 1034–50.Google ScholarPubMed
165Percy, ME, Markovic, VD, Crapper-McLachlan, DR et al. Family with 22-derived marker chromosome and late onset dementia of the Alzheimer type: 1 application of a new model for estimation of the risk of disease associated with the marker. Am J Med Genet 1991; 39: 307–13.CrossRefGoogle ScholarPubMed
166Schellenberg, GD, Boehinke, M, Wijsman, EM, Moore, DK, Martin, GM, Bird, TD.Genetic association and linkage analysis of the apolipoprotein CII locus and familial Alzheimer's disease. Ann Neurol 1992; 31: 223–27.CrossRefGoogle ScholarPubMed
167Namba, Y, Tomonaga, M, Kawasaki, H, Otomo, E, Ikeda, K.Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and Kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res 1991; 541: 163–66.CrossRefGoogle ScholarPubMed
168Strittmatter, WJ, Saunders, AN, Schmechel, D et al. Apolipoprotein E: high-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer's disease. Proc Natl Acad Sci USA 1993; 90: 1977–81.CrossRefGoogle Scholar
169Mann, DMA.The pathological association between Down's syndrome and Alzheimer's disease. Mech Ageing Dev 1988; 43: 99136.CrossRefGoogle Scholar
170Arriagada, PV, Marzloff, K, Hymann, BT.Distribution of Alzheimer-type pathologic changes in non-demented elderly individuals matches the pattern of Alzheimer's disease. Neurology 1992; 42: 1681–88.CrossRefGoogle Scholar
171Hof, PR, Bierer, LM, Perl, DP et al. Evidence for early vulnerability of the medial and inferior aspects of the temporal lobe in an 82 year old with preclinical signs of dementia. Arch Neurol 1992; 49: 946–53.CrossRefGoogle Scholar
172Braak, H, Braak, E.Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 1991; 82: 239–59.CrossRefGoogle ScholarPubMed
173Citron, M, Oltersdorf, T, Haass, C et al. Mutation of the β amyloid precursor protein in familial Alzheimer's disease increases β-protein production. Nature 1992; 360: 672–74.CrossRefGoogle ScholarPubMed
174Rumble, B, Retallack, R, Hilbich, C et al. Amyloid (A4) protein and its precursor in Down's syndrome and Alzheimer's disease. N Engl J Med 1989; 320: 1446–52.CrossRefGoogle ScholarPubMed
175Nixon, RA, Cataldo, RM, Mann, DMA et al. Abnormalities of lysosomal proteolysis in neurons in Alzheimer's disease and Down's syndrome: possible relationship to β-amyloid deposition. In: Corain, B, Iqbal, K, Nicolini, M, Winblad, B, Wisniewski, HM, Zatta, P eds. Alzheimer's disease: advances in clinical and basic research. Chichester: Wiley, 1993: 441–50.Google Scholar
176Hanger, DP, Mann, DMA, Neary, D, Anderton, BH.Tau pathology in a case of familial Alzheimer's disease with a valine to glycine mutation at position 717 of the amyloid precursor protein. Neurosci Lett 1992; 145: 178–80.CrossRefGoogle Scholar
177Yoshikawa, K, Aizawa, T, Hayashi, Y.Degeneration in vitro of postmitotic neurones overexpressing the amyloid protein precursor. Nature 1992; 359: 6467.CrossRefGoogle ScholarPubMed
178Yankner, BA, Dawes, LR, Fisher, S, Villa-Komaroff, L, Oster-Granite, ML, Neve, RL.Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 1989; 245: 417–20.CrossRefGoogle ScholarPubMed
179Maruyama, K, Terakado, K, Usami, M, Yoshikawa, K.Formation of amyloid-like fibrils in COS cells overexpressing part of the Alzheimer amyloid protein precursor. Nature 1990; 347: 566–68.CrossRefGoogle ScholarPubMed
180Kammesheidt, A, Boyce, M, Spanoyannis, AF et al. Deposition of β/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxy-terminal fragment of Alzheimer amyloid precursor in the brain. Proc Natl Acad Sci USA 1992; 89: 10857–61.CrossRefGoogle Scholar
181 Various Authors: Is β amyloid neurotoxic? Neurobiol Ageing 1992; 13: 535625.Google Scholar
182Neve, RL, Kammesheidt, A, Hohmann, CF.Brain transplants of cells expressing the carboxyl-terminal fragment of the Alzheimer amyloid protein precursor cause specific neuropathology in vivo. Proc Natl Acad Sci USA 1992; 89: 3448–52.CrossRefGoogle ScholarPubMed
183Tabaton, M, Mandybur, TI, Perry, G, Onorato, M, Autilio-Gambetti, L, Gambetti, P.The widespread alteration of neurites in Alzheimer's disease may be unrelated to amyloid deposition. Ann Neurol 1989; 26: 771–78.CrossRefGoogle ScholarPubMed
184Kiuchi, A, Otsuka, N, Namba, Y, Nakano, I, Tomonaga, M.Presenile appearance of abundant neurofibrillary tangles without senile plaques in the brain in myotonic dystrophy. Acta Neuropathol 1991; 82: 15.CrossRefGoogle ScholarPubMed
185Roberts, GW, Allsop, D, Burton, C.The occult aftermath of boxing. J Neurol Neurosurg Psychiatry 1990; 53: 373–78.CrossRefGoogle ScholarPubMed
186Dale, GE, Leigh, PN, Luthert, P, Anderton, BH, Roberts, GW.Neurofibrillary tangles in dementia pugilistica are ubiquitinated. J Neurol Neurosurg Psychiatry 1991; 54: 116–18.CrossRefGoogle ScholarPubMed
187Masliah, E, Terry, RD, Mallory, M, Alford, M, Hansen, LA.Diffuse plaques do not accentuate synapse loss in Alzheimer's disease. Am J Pathol 1990; 137: 1293–97.Google Scholar
188Hsaio, K, Dloughy, S, Ghetti, B, Farlow, M.Mutant prion proteins in Gerstmann-Straussler-Scheinker disease with neurofibrillary tangles. Nature Genet 1992; 1: 6871.CrossRefGoogle Scholar
189Giaccone, G, Tagliavini, L, Verga, L et al. Neurofibrillary tangles of the Indiana kindred of Gerstmann-Straussler-Sheinker disease share antigenic determinants with those of Alzheimer's disease. Brain Res 1990; 530: 325–29.CrossRefGoogle Scholar
190Amano, N, Yagishita, S, Yokoi, S et al. Gerstmann-Straussler syndrome - a variant type: amyloid plaques and Alzheimer's neurofibrillary tangles in the cerebral cortex. Acta Neuropathol 1992; 84: 1523.CrossRefGoogle Scholar
191Nochlin, D, Sumi, SM, Bird, TD et al. Familial dementia with PrP positive amyloid plaques: a variant of Gerstmann-Straussler syndrome. Neurology 1989; 39: 910–18.CrossRefGoogle ScholarPubMed