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Ultrastructural and biochemical basis of Alzheimer's disease

Published online by Cambridge University Press:  17 November 2008

BH Anderton*
Affiliation:
Institute of Psychiatry, London, UK
Jean-Pierre Brion
Affiliation:
Université Libre de Bruxelles, Belgium
*
Professor BH Anderton, Department of Neuroscience, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK.

Abstract

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Type
Biological gerontology
Copyright
Copyright © Cambridge University Press 1991

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References

1Bowen, DM, Francis, PF. Neurochemistry, neuropharmacology and aetiological factors in Alzheimer's disease. Sem Neurosci 1990; 2 (in press).Google Scholar
2Wischik, CM, Crowther, RA, Stewart, M, Roth, M. Subunit structure of paired helical filaments in Alzheimer's disease. J Cell Biol 1985; 100: 1905–12.CrossRefGoogle ScholarPubMed
3Himmler, A, Drechsel, D, Kirschner, MW, Martin, DW. Tau consists of a set of proteins with replicated C-terminal microtubule-binding domains and variable N-terminal domains. Mol Cell Biol 1989; 9: 1381–88.Google Scholar
4Goedert, M, Spillantini, MG, Jakes, R, Rutherford, D, Crowther, RA. Sequences of multiple isoforms of human microtubule-associated protein tau and their presence in neurofibrillary tangles of Alzheimer's disease. Neuron 1989; 3: 519–26.CrossRefGoogle Scholar
5Brion, J-P, Passareiro, H, Nunez, J, Flament-Durand, J. Mise en évidence immunologique de la proteine tau au niveau des lesions de dégénérescence neurofibrillaire de la maladie d'Alzheimer. Arch Biol (Brux) 1985; 95: 229–35.Google Scholar
6Wischik, CM, Novak, M, Thogersen, HC et al. Isolation of a fragment of tau derived from the core of the paired helical filaments of Alzheimer disease. Proc Natl Acad Sci USA 1988; 85: 4506–10.CrossRefGoogle ScholarPubMed
7Delacourte, A, Defossez, A. Alzheimer's disease: tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments. J Neural Sci 1986; 76: 173–86.CrossRefGoogle ScholarPubMed
8Kosik, KS, Joachim, CL, Selkoe, DJ. The microtubule-associated protein, tau, is a major antigenic component of paired helical filaments in Alzheimer's disease. Proc Natl Acad Sci USA 1986; 83: 4044–48.CrossRefGoogle Scholar
9Kondo, L, Honda, T, Mori, et al. The carboxy third of tau is tightly bound to paired helical filaments. Neuron 1988; 1: 827–34.CrossRefGoogle ScholarPubMed
10Wischik, CM, Novak, M, Edwards, PC, Klug, A, Tichelaar, W, Crowther, RA. Structural characterization of the core of the paired helical filament of Alzheimer's disease. Proc Nail Acad Sci USA 1988; 85: 4884–88.CrossRefGoogle Scholar
11Mori, H, Kondo, J, Ihara, Y. Ubiquitin is a component of paired helical filaments in Alzheimer's disease. Science 1987; 325: 1641–44.CrossRefGoogle Scholar
12Brion, J-P, Power, D, Hue, D, Couck, AM, Anderton, BH, Flament-Durand, J. Heterogeneity of ubiquitin immunoreactivity in neurofibrillary tangles of Alzheimer's disease. Neurochem Int 1989; 14: 121–28.CrossRefGoogle ScholarPubMed
13Miller, CCJ, Brion, J-P, Calvert, R et al. Alzheimer's paired helical filaments share epitopes with neurofilaments side arms. EMBO J 1986; 5: 269–76.CrossRefGoogle ScholarPubMed
14Kosik, KS, Orecchio, LD, Bakalis, S, Duffy, L, Neve, RL. Partial sequence of MAP2 in the region of shared epitope with Alzheimer neurofibrillary tangles. J Neurochem 1988; 51: 587–98.CrossRefGoogle ScholarPubMed
15Lee, VM-Y, Otvos, L Jr, Schmidt, ML, Trojanowski, JQ. Alzheimer disease tangles share immunological similarities with multiphosphorylation repeats in the two large neurofilament proteins. Proc Natl Acad Sci USA 1988; 85: 7384–88.CrossRefGoogle ScholarPubMed
16Coleman, MP, Anderton, BH. Phosphate-dependent monoclonal antibodies to neurofilaments and Alzheimer neurofibrillary tangles recognize a synthetic phosphopeptide. J Neurochem 1990 (in press).CrossRefGoogle Scholar
17Kosik, KS, Duffy, LK, Dowling, MM, Abraham, C, McCluskey, A, Selkoe, DJ. Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles. Proc Natl Acad Sci USA 1984; 81: 7941–45.CrossRefGoogle ScholarPubMed
18Wolozin, BL, Pruchnicki, A, Dickson, DW, Davies, P. A neuronal antigen in the brains of Alzheimer patients. Science 1986; 232: 648–50.CrossRefGoogle ScholarPubMed
19Wolozin, BL, Davies, P. Alzheimer-related neuronal protein A68: Specificity and distribution. Ann Neural 1987; 22: 521–26.CrossRefGoogle ScholarPubMed
20Nukina, N, Kosik, KS, Selkoe, DJ. The monoclonal antibody, Alz 50, recognizes tau proteins in Alzheimer's disease brain. Neurosci Lett 1988; 87: 240–46.CrossRefGoogle ScholarPubMed
21Masters, CL, Multhaup, G, Simms, G, Pottgiesser, J, Martins, RN, Beyreuther, K. Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid plaque cores and blood vessels. EMBO J 1985; 4: 2757–63.CrossRefGoogle ScholarPubMed
22Grundke-Iqbal, I, Iqbal, IK, Tung, YC, Quinlan, M, Wisniewski, HM, Binder, U. Abnormal phosphorylation of the microtubule-associated protein tau in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA 1986; 83: 4913–17.CrossRefGoogle ScholarPubMed
23Flament, S, Delacourte, A, Hemon, B, Defossez, A. Characterization of two pathological tau protein variants in Alzheimer brain cortices. J Neural Sci 1989; 92: 133–41.CrossRefGoogle ScholarPubMed
24Kowall, NW, Kosik, KS. Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease. Ann Neural 1987; 22: 639–43.CrossRefGoogle ScholarPubMed
25Richard, S, Brion, J-P, Couck, A, Flament-Durand, J. Accumulation of smooth endoplasmic reticulum in Alzheimer's disease: new morphological evidence of axoplasmic flow disturbances. J Submicrosc Cytol 1989; 21: 461–67.Google ScholarPubMed
26Glenner, GG, Wong, CW. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 1984; 120: 885–90.CrossRefGoogle ScholarPubMed
27Masters, CL, Simms, G, Winman, NA, Multhaup, G, McDonald, BL, Beyreuther, K. Amyloid plaque core protein in Alzheimer's disease and Down syndrome. Proc Natl Acad Sci USA 1985; 82: 4245–49.CrossRefGoogle ScholarPubMed
28Kirschner, DA, Inouye, H, Duffy, LK, Sinclair, A, Lind, M, Selkoe, DJ. Synthetic peptide homologous to B protein from Alzheimer disease forms amyloid-like fibrils in vitro. Proc Natl Acad Sci USA 1987; 84: 6953–57.CrossRefGoogle Scholar
29Candy, JM, Oakley, AE, Klinowski, J et al. Aluminosilicates and senile plaque formation in Alzheimer's disease. Lancet 1986; i: 354–57.CrossRefGoogle Scholar
30Martyn, CN, Osmond, C, Edwardson, JA, Barker, DJP, Harris, EC, Lacey, RF. Geographical relation between Alzheimer's disease and aluminium in drinking water. Lancet 1989; i: 5962.CrossRefGoogle Scholar
31Kang, J, Lemaire, HF, Unterbeck, A et al. The precursor of Alzheimer's disease amyloid A4 resembles a cell-surface receptor. Nature 1987; 325: 733–36.CrossRefGoogle ScholarPubMed
32Tanzi, RE, McClatchey, AJ, Lampert, ED. Villa-Komaroff, L, Gusella, JF, Neve, RE. Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease. Nature 1988; 331: 528–30.CrossRefGoogle ScholarPubMed
33Kitaguchi, N, Takahashi, Y, Tokushima, Y, Shiojiri, S, Ito, H. Novel precursor of Alzheimer's disease amyloid protein shows inhibitory activity. Nature 1988; 331: 530–32.CrossRefGoogle ScholarPubMed
34Ponte, P, Gonzalez-DeWhitt, P, Schilling, J et al. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature 1988; 331: 525–27.CrossRefGoogle ScholarPubMed
35De Sauvage, F, Octave, JN. A novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein. Science 1989; 245: 651–53.CrossRefGoogle ScholarPubMed
36Goedert, M. Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and Alzheimer's disease. EMBO J 1987; 6: 3627–32.CrossRefGoogle Scholar
37Smith, RP, Higuchi, DA, Broze, GJ. Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor protein. Science 1990; 248: 1126–28.CrossRefGoogle ScholarPubMed
38Van Nostrand, WE, Wagner, SL, Suzuki, M et al. Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid B-protein precursor. Nature 1989; 341: 546–49.CrossRefGoogle Scholar
39Van Nostrand, WE, Cunningham, DD. Purification of protease nexin II from human fibroblasts. J Biol Chem 1987; 262: 8508–14.CrossRefGoogle ScholarPubMed
40Saitoh, T, Sundsmo, M, Roch, JM et al. Secreted form of amyloid beta precursor is involved in the growth regulation of fibroblasts. Cell 1989; 58: 615–22.CrossRefGoogle ScholarPubMed
41Monard, D. Cell-derived proteases and protease inhibitors as regulators of neurite outgrowth. TINS 1988; 11: 541–44.Google ScholarPubMed
42Doyle, E, Bruce, MT, Breen, KC, Smith, DC, Anderton, BH, Regan, CM. Intraventricular infusion of antibodies to amyloid-beta-protein precursor impair the acquisition of a passive avoidance response in the rat. Neurosci Lett 1990 (in press).CrossRefGoogle Scholar
43Allsop, D, Wong, CW, Ideda, SI, Landon, M, Kidd, M, Glenner, GG. Immunohistochemical evidence for the derivation of a peptide ligand from the amyloid B-protein precursor of Alzheimer's disease. Proc Natl Acad Sci USA 1988; 85: 2790–94.CrossRefGoogle Scholar
44Van Broeckhoven, C, Genthe, AM, Vandenberghe, A et al. Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families. Nature 1987; 329: 153–55.CrossRefGoogle ScholarPubMed
45Van Broeckhoven, C, Haan, J, Bakker, E et al. Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch). Science 1990; 248: 1120–22.CrossRefGoogle ScholarPubMed
46Levy, E, Carman, MD, Fernandez-Madrid, IJ et al. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science 1990; 248: 1124–26.CrossRefGoogle ScholarPubMed
47Lemaire, HG, Salbaum, JM, Multhaup, G et al. The PreA4695 precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons. Nucleic Acids Res 1989; 17: 517–22.CrossRefGoogle ScholarPubMed
48Neve, RL, Finch, EA, Dawes, LR. Expression of the Alzheimer amyloid precursor gene transcripts in the human brain. Neuron 1988; 1: 669–77.CrossRefGoogle ScholarPubMed
49Higgins, GA, Lewis, DA, Bahamanyar, S et al. Differential regulation of amyloid-beta-protein mRNA expression within hippocampal neuronal subpopulations in Alzheimer's disease. Proc Natl Acad Sci USA 1988; 85: 12971301.CrossRefGoogle Scholar
50Cohen, ML, Golde, TE, Usiak, MF, Younkin, LH, Younkin, SG. In situ hybridization of nucleus basalis neurones shows increased beta-amyloid mRNA in Alzheimer's disease. Proc Natl Acad Sci USA 1988; 85: 1227–31.CrossRefGoogle Scholar
51Clark, AW, Krekoski, CA, Parhad, IM, Listen, D, Julien, J-P, Hoar, DI. Altered expression of genes for amyloid and cytoskeletal proteins in Alzheimer cortex. Ann Neural 1989; 25: 331–39.CrossRefGoogle ScholarPubMed
52Palmert, MR, Golde, TE, Cohen, ML et al. Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease. Science 1988; 241: 1080–84.CrossRefGoogle ScholarPubMed
53Sisodia, SS, Koo, EH, Beyreuther, K, Unterbeck, A, Price, DL. Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science 1990; 248: 492–95.CrossRefGoogle Scholar
54Esch, FS, Keim, PS, Beattie, EC et al. Cleavage of amyloid beta-peptide during constitutive processing of its precursor. Science 1990; 248: 1122–24.CrossRefGoogle ScholarPubMed
55Joachim, CL, Mori, H, Selkoe, DJ, Amyloid B-protein deposition in tissues other than brain Alzheimer's disease. Nature 1989; 341: 226–30.CrossRefGoogle Scholar
56Yankner, BA, Dawes, LR, Fisher, S, Villa-Komaroff, L, Oster-Grannite, ML, Neve, RL. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 199; 245: 417–20.CrossRefGoogle Scholar
57Whitson, JS, Selkoe, DJ, Cotman, CW. Amyloid beta-protein enhances the survival of hippocampal neurons in vitro. Science 1989; 243: 1488–90.CrossRefGoogle ScholarPubMed