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Mild cognitive impairment and mood: a systematic review

Published online by Cambridge University Press:  06 November 2013

Jennifer A Yates ,
Linda Clare  and
Robert T Woods
Jennifer A Yates*
Affiliation:
Dementia Services Development Centre, Bangor University, Bangor, UK
Linda Clare
Affiliation:
Dementia Services Development Centre, Bangor University, Bangor, UK
Robert T Woods
Affiliation:
Dementia Services Development Centre, Bangor University, Bangor, UK
*
Address for correspondence: Miss Jennifer Yates, Dementia Services Development Centre, 45 College Road, Bangor Gwynedd LL57 2DG Email: [email protected]
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Summary

This systematic review, with meta-analyses conducted where data were available, aimed to investigate the prevalence of symptoms of depression and anxiety in mild cognitive impairment (MCI), and to establish how symptoms of depression and anxiety relate to the progression from no cognitive impairment to MCI, and from MCI to dementia. Sixty studies were included in the review. Meta-analyses indicated that symptoms of depression and anxiety were more prevalent in people with MCI than in people with normal cognitive function, and increased the risk of progression from no cognitive impairment to MCI. There were mixed results regarding the effect of such symptoms on progression from MCI to dementia. The findings highlight the need for more research in this area, which can inform attempts to slow or halt the progression of cognitive impairment in later life, with resulting benefits for quality of life.

Keywords

depressionanxietymemorymeta-analysisneuropsychiatric symptoms
Type
Review Article
Information
Reviews in Clinical Gerontology , Volume 23 , Issue 4 , November 2013 , pp. 317 - 356
Copyright
Copyright © Cambridge University Press 2013 

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