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The epidemiology of age-related neurological disease and dementia

Published online by Cambridge University Press:  17 November 2008

DWK Kay
DWK Kay*
Affiliation:
MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne, UK
*
DWK Kay, 8 Grosvenor Place, Newcastle upon Tyne NE2 2RE, UK.
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Abstract

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Type
Psychiatry of old age
Information
Reviews in Clinical Gerontology , Volume 5 , Issue 1 , February 1995 , pp. 39 - 56
Copyright
Copyright © Cambridge University Press 1995

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References

1 Kay, DWK. The epidemiology of dementia: a review of recent work. Rev Clin Geront 1991; 1: 55–66.Google Scholar
2 Calne, DB, Eisen, A. Parkinson's disease: motorneuron disease and Alzheimer's disease: origins and interrelationships. Adv Neurology 1990; 53: 355–60.Google Scholar
3 Cooper, B. The epidemiology of primary degenerative dementia and related neurological disorders. Eur Arch Psychiatr Clin Neurosci 1991; 240: 223–33.Google Scholar
4 Lobo, A, Dewey, ME, Copeland, JRM et al. The prevalence of dementia among elderly people living in Zaragoza and Liverpool. Psychol Med 1992; 22: 239–43.Google Scholar
5 Saunders, PA, Copeland, JRM, Dewey, ME et al. The prevalence of dementia, depression and neurosis in later life: the Liverpool MRC-ALPHA study. Int J Epidemiol 1993; 22: 838–47.Google Scholar
6 Fratiglioni, L, Grut, M, Forsell, Y et al. Prevalence of Alzheimer's disease and other dementias in an elderly urban population: relationship with age, sex, and education. Neurology 1991; 41: 1886–92.CrossRefGoogle Scholar
7 Breteler, MMB, van den Ouweland, FA, Grobbee, DE, Hofman, A. A community-based study of dementia: the Rotterdam elderly study. Neuroepidemiology 1992; 11 (suppl 1): 23–28.Google Scholar
8 Engedal, K, Haugen, PK. The prevalence of dementia in a sample of elderly Norwegians. Int J Geriatr Psychiatry 1993; 8: 565–70.Google Scholar
9 Juva, K, Sulkava, R, Erkinjuntti, et al. Prevalence of dementia in the city of Helsinki. Acta Neurol Scand 1993; 87: 106–10.Google Scholar
10 Jagger, C, Clarke, M, Anderson, J, Battcock, T. Dementia in Melton Mowbray–a validation of earlier findings. Age Ageing 1992; 21: 205–10.CrossRefGoogle ScholarPubMed
11 Heeren, TJ, Lagaay, AM, Hijmans, W, Rooymans, HGM. Prevalence of dementia in the ‘oldest old’ of a Dutch community. J Am Geriatr Soc 1991; 39: 755–59.Google Scholar
12 Bachman, MD, Wolf, PA, Linn, R et al. Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham study. Neurology 1992; 42: 115–19.CrossRefGoogle ScholarPubMed
13 Folstein, MF, Bassett, SS, Anthony, JC et al. Dementia: case ascertainment in a community survey. J Gerontol 1991; 46: M132–38.Google Scholar
14 Aronson, MK, Ooi, WL, Deva, DL et al. Age-dependent incidence, prevalence, and mortality in the old old. Arch Intern Med 1991; 151: 989–92.Google Scholar
15 Skoog, I, Nilsson, L, Palmertz, B et al. A population-based study of dementia in 85-year-olds. New Engl J Med 1993; 328: 153–58.Google Scholar
16 Wernicke, TF, Reischies, FM. Prevalence of dementia in old age: clinical diagnoses in subjects aged 95 years and older. Neurology 1994; 44: 250–53.Google Scholar
17 Folstein, MF, Folstein, SE, McHugh, PR. ‘Minimental state’. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 89–98.Google Scholar
18 American Psychiatric Association. Diagnostic and statistical manual of mental disorders, third edition, revised. Washington DC: American Psychiatric Association, 1987.Google Scholar
19 Roth, M, Huppert, FA, Tym, E, Mountjoy, CQ. CAMDEX; the Cambridge examination for mental disorders in the elderly. Cambridge: Cambridge University Press, 1988.Google Scholar
20 Copeland, JRM, Dewey, ME, Griffiths-Jones, HM. Computerised psychiatric diagnostic system and case nomenclature for elderly subjects: GMS and AGECAT. Psychol Med 1986; 16: 89–99.Google Scholar
21 Berg, L. Clinical Dementia Rating (CDR). Psychopharm Bull 1988; 24; 637–39.Google Scholar
22 Park, J, Ko, HJ, Park, YN, Jung, C-H. Dementia among the elderly in a rural Korean community. Prevalence and cause. Br J Psychiatry 1994; 164: 796–801.Google Scholar
23 Copeland, JRM, Dewey, ME, Saunders, P. The epidemiology of dementia: GMS-AGECAT studies of prevalence and incidence, including studies in progress. Eur Arch Psychiatry Clin Neurosci 1991; 240: 212–17.Google Scholar
24 Hofman, A, Rocca, WA, Brayne, C, Breteler, MMB et al. The prevalence of dementia in Europe: a collaborative study of 1980–1990 findings. Int J Epidemiol 1991; 20: 736–48 (for the EURODEM Prevalence Research Group).Google Scholar
25 Jorm, AF, Korten, AE, Henderson, AS. The prevalence of dementia: a quantitative integration of the literature. Acta Psychiatr Scand 1987; 76: 465–79.Google Scholar
26 Ritchie, K, Kildea, D, Robine, J-M. The relationship between age and the prevalence of senile dementia: a meta-analysis of recent data. Int J Epidemiol 1992; 21: 763–69.Google Scholar
27 Burvill, PW. A critique of current criteria for early dementia in epidemiological studies. Int J Geriatr Psychiatry 1993; 8: 553–59.Google Scholar
28 Kay, DWK. Ageing and cognition: approaches to the diagnosis of dementia in the community. In: Robine, J-M, Mathers, CD, Bone, M, Romieu, I eds. Calculation of health expectancies: harmonization, consensus achieved and future prospectives. Montrouge: Colloque INSERM/John Libbey Eurotext Ltd, 1993: 51–61.Google Scholar
29 Barberger-Gateau, P, Commenges, D, Gagnon, M et al. Instrumental activities of daily living as a screening tool for cognitive impairment and dementia in elderly community dwellers. J Am Geriatr Soc 1992; 40: 1129–34.Google Scholar
30 Barberger-Gateau, P, Dartigues, J-F, Letenneur, L. Four instrumental activities of daily living score as a predictor of one-year incident dementia. Age Ageing 1993; 22: 457–63.Google Scholar
31 Laukkanen, P, Kauppinen, M, Era, P, Heikkinen, E. Factors related to coping with physical and instrumental activities of daily living among people born in 1904–1923. Int J Geriatr Psychiatry 1993; 8: 287–96.Google Scholar
32 Barberger-Gateau, P, Chaslerie, A, Dartigues, J-P et al. Health measures correlates in a French elderly community population: the PAQUID study. J Gerontol Soc Sci 1992; 47: S88–95.Google Scholar
33 Meller, I, Fichter, M, Schreppel, H, Beck-Eichinger, M. Mental and somatic health and need for care in octo- and nonagenarians. Eur Arch Psychiatry Clin Neurosci 1993; 242: 286–92.Google Scholar
34 Mutch, WJ, Strudwick, A, Roy, SK, Downie, AW. Parkinson's disease: disability, review, and management. Br Med J 1986; 293: 675–77.Google Scholar
35 O'Connor, DW, Pollitt, PA, Brook, CPB, Reiss, BB. A community survey of mental and physical infirmity in nonagenarians. Age Ageing 1989; 18: 411–14.Google Scholar
36 Ritchie, K, Jagger, C, Brayne, C, Letenneur, L. Life expectancy free of mental impairment: methods and preliminary calculations. In: Robine, J-M, Mathers, CD, Bone, M, Romieu, I eds. Calculation of health expectancies: harmonization, consensus achieved and future prospectives. Montrouge: Colloque INSERM/John Libbey Eurotext Ltd, 1993: 233–44.Google Scholar
37 Brewis, M, Poskanzer, CR, Miller, H. Neurological disease in an English city. Acta Neurol Scand 1966; 42 (suppl): 1–89.Google Scholar
38 Anderson, DW, Schoenberg, DG eds. Neuroepidemiology: a tribute to Bruce Schoenberg. Boca Raton, FL: CRC Press, 1991.Google Scholar
39 Cockerell, OC, Sander, JWAS, Shorvon, SD. Neuroepidemiology in the United Kingdom [Editorial]. J Neurol Neurosurg Psychiatry 1993; 56: 735–38.Google Scholar
40 Copeland, JRM, Davidson, IA, Dewey, ME et al. Alzheimer's disease, other dementias, depression and pseudo-dementia: prevalence, incidence and three-year outcome in Liverpool. Br J Psychiatry 1992; 161: 230–39.Google Scholar
41 Rocca, WA, Hofman, A, Brayne, C et al. Frequency and distribution of Alzheimer's disease in Europe: a collaborative study of 1980–1990 prevalence findings. Ann Neurol 1991; 30: 381–90 (for the EURODEM-Prevalence Research Group).Google Scholar
42 Rocca, WA, Hofman, A, Brayne, C et al. The prevalence of vascular dementia in Europe: facts and fragments from 1980–1990 studies. Ann Neurol 1991; 30: 817–24 (for the EURODEM-Prevalence Research Group).Google Scholar
43 Newens, AJ, Forster, DP, Kay, DWK et al. Clinically diagnosed presenile dementia of the Alzheimer type in the Northern Health Region: ascertainment, prevalence, incidence and survival. Psychol Med 1993; 23: 631–44.Google Scholar
44 Mutch, WJ, Dingwall-Fordyce, I, Downie, AW et al. Parkinson's disease in a Scottish city. Br Med J 1986; 292: 534–36.Google Scholar
45 Mogante, L, Rocca, WA, Di Rosa, AE et al. Prevalence of Parkinson's disease and other types of parkinsonism: a door-to-door survey in three Sicilian municipalities. Neurology 1992: 42: 1901–907.Google Scholar
46 Rosati, G, Pinna, L, Granieri, E et al. Studies on epidemiological, clinical and etiological aspects of ALS disease in Sardinia, Southern Italy. Acta Neurol Scand 1977; 55: 231–44.Google Scholar
47 Clark, ID, Opit, LJ. The prevalence of stroke in those at home and the need for care. J Pub Health Med 1994; 16: 93–96.Google Scholar
48 Kokmen, E, Beard, M, Offord, KP, Kurland, LT. Prevalence of medically diagnosed dementia in a defined United States population: Rochester, Minnesota, 1 January 1975. Neurology 1989; 39: 773–75.Google Scholar
49 Marder, K, Leung, D, Tang, M et al. Are demented patients with Parkinson's disease accurately reflected in prevalence surveys? A survival analysis. Neurology 1991; 41: 1240–43.Google Scholar
50 Neary, D. Non-Alzheimer's disease forms of cerebral atrophy. J Neurol Neurosurg Psychiatry 1990; 53: 929–31.Google Scholar
51 The Lund and Manchester Groups. Clinical and neuropathological criteria for frontotemporal dementia. J Neurol Neurosurg Psychiatry 1994; 57: 416–18.Google Scholar
52 Hudson, AJ. Amyotrophic lateral sclerosis and its association with dementia, parkinsonism and other neurological disorders: a review. Brain 1981; 104: 217–47.Google Scholar
53 Xuereb, JH, Tomlinson, BE, Irving, D et al. Cortical and subcortical pathology in Parkinson's disease: relationship to parkinsonian dementia. In: Streiffler, MB, Korczyn, AD, Melamed, E, Youdim, MBH eds. Advances in neurology, Volume 53: Parkinson's disease: anatomy, pathology, and therapy. New York: Raven Press, 1990: 35–40.Google Scholar
54 Brown, RG, Marsden, CD. How common is dementia in Parkinson's disease? Lancet 1984; ii: 1262–65.Google Scholar
55 Hofman, A, Schulte, W, Tanja, TA et al. History of dementia and Parkinson's disease in 1st-degree relatives of patients with Alzheimer's disease. Neurology 1989; 39: 1589–92.Google Scholar
56 Biggins, CA, Boyd, JL, Harrop, FM et al. A controlled, longitudinal study of dementia in Parkinson's disease. J Neurol Neurosurg Psychiatry 1992; 55: 566–71.Google Scholar
57 Mayeux, R, Chen, J, Mirabello, E et al. An estimate of the incidence of dementia in idiopathic Parkinson's disease. Neurology 1990; 40: 1513–17.Google Scholar
58 Mayeux, R, Denaro, J, Hemenegildo, N et al. A population-based investigation of Parkinson's disease with and without dementia. Arch Neurol 1992; 49: 492–97.Google Scholar
59 Stern, Y, Marder, K, Tang, MX, Mayeux, R. Antecedent clinical features associated with dementia in Parkinson's disease. Neurology 1993; 43: 1690–92.Google Scholar
60 Ebmeier, KP, Calder, SA, Crawford, JR et al. Parkinson's disease in Aberdeen: survival after 3.5 years. Acta Neurol Scand 1989; 81: 294–99.CrossRefGoogle Scholar
61 Sorensen, PS, Boysen, G, Jensen, G, Schnohr, P. Prevalence of stroke in a district of Copenhagen. Acta Neurol Scand 1982; 66: 68–81.Google Scholar
62 McKeith, IG, Perry, RH, Jabeen, S et al. Operational criteria for senile dementia of the Lewy body type (SDLT). Psychol Med 1992; 22: 911–22.Google Scholar
63 Gustafson, L. Clinical picture of frontal lobe degeneration of non-Alzheimer type. Dementia 1993; 4: 143–48.Google Scholar
64 Gregory, CA, Hodges, D. Dementia of frontal lobe type and the focal lobar atrophies. Int Rev Psychiatry 1993; 5: 397–406.Google Scholar
65 Orrell, MW, Sahakian, BJ, Bergmann, K. Self-neglect and frontal lobe dysfunction. Br J Psychiatry 1989; 155: 101–105.Google Scholar
66 Paykel, ES, Brayne, C, Huppert, FA et al. Incidence of dementia in a population older than 75 years in the United Kingdom. Arch Gen Psychiatry 1994; 51: 325–32.Google Scholar
67 Bachman, DL, Wolf, PSA, Linn, RT et al. Incidence of dementia and probable Alzheimer's disease in a general population: The Framingham Study. Neurology 1993; 43: 515–19.Google Scholar
68 Boothby, H, Blizard, R, Livingston, G, Mann, AH. The Gospel Oak study stage III: the incidence of dementia. Psychol Med 1994; 24: 89–95.Google Scholar
69 Morgan, K, Lilley, JM, Arie, T et al. Incidence of dementia in a representative British sample. Br J Psychiatry 1993; 163: 467–70.Google Scholar
70 Kokmen, E, Beard, CM, O'Brien, PC et al. Is the incidence of dementing illness changing? A 25-year time trend study in Rochester, Minnesota (1960–1984). Neurology 1993; 43: 1887–92.Google Scholar
71 Li, G, Shen, YC, Zhau, YW et al. A three-year follow up study of age-related dementia in an urban area of Beijing. Acta Psychiatr Scand 191; 83: 99–104.Google Scholar
72 Bickel, H, Cooper, B. Incidence and relative risk of dementia in an urban elderly population: findings of a prospective field study. Psychol Med 1994; 24: 179–92.Google Scholar
73 Hagnell, O, Essen-Muller, E, Lanke, J et al. The incidence of mental illness over a quarter of a century. The Lundby longitudinal study. Stockholm: Almquist & Wiksell International, 1990: Table 92c.Google Scholar
74 Dartigues, J-F. Quoted in Breteler, MMB, Claus, JJ, van Duijn, CM et al. Epidemiology of Alzheimer's disease. Epidemiol Reviews 1992; 14: 59–82.Google Scholar
75 Copeland, JRM. Quoted in Breteler, MMB, Claus, JJ, van Duijn, CM et al. Epidemiology of Alzheimer's disease. Epidemiol Reviews 1992; 14: 59–82.Google Scholar
76 Hagnell, O, Ojesjo, L, Rorsman, B. Incidence of dementia in the Lundby study. Neuroepidemiology 1992; 11 (suppl 1): 61–66.Google Scholar
77 Launer, LJ. Overview of incidence studies of dementia conducted in Europe. Neuroepidemiology 1992; 11 (suppl 1): 2–13.Google Scholar
78 Marttila, RL, Rinne, UK. Epidemiology of Parkinson's disease in Finland. Acta Neurol Scand 1976; 53: 81–102.Google Scholar
79 Rajput, AH, Offord, KP, Beard, CM, Kurland, LT. A case–control study of smoking habits, dementia, and other illnesses in idiopathic Parkinson's disease. Neurology 1987; 37: 226–32.Google Scholar
80 Yoshida, S, Mulder, DW, Kurland, LT et al. Follow-up study on amyotrophic lateral sclerosis in Rochester, Minn., 1925 through 1984. Neuroepidemiology 1986; 5: 61–70.CrossRefGoogle ScholarPubMed
81 Bamford, J, Sandercock, P, Dennis, M et al. A prospective study of acute cerebrovascular disease in the community: the Oxfordshire Community Stroke Project 1981–86. 1. Methodology, demography and incident cases of first-ever stroke. J Neurol Neurosurg Psychiatry 1988; 51: 1373–80.Google Scholar
82 Chandra, V, Kokmen, E, Whisnant, J. Epidemiology of dementia from cerebral infarction: a population-based study. Neurology 1987; 37 (suppl 1): 279–80.Google Scholar
83 Koller, W, O'Hara, R, Weiner, W et al. Relationship of aging to Parkinson's disease. In: Yahr, MD, Bergmann, KJ eds. Advances in neurology, Volume 45. New York: Raven Press, 1987: 317–21.Google Scholar
84 Aronson, MK, Ooi, WL, Morgenstern, H et al. Women, myocardial infarction, and dementia in the very old. Neurology 1990; 40: 1102–106.Google Scholar
85 Davis, PH, Hachinski, V. Epidemiology of cerebrovascular disease. In: Anderson, DW, Schoenberg, DG eds. Neuroepidemiology: A tribute to Bruce Schoenberg. Boca Raton, FL: CRC Press, 1991: 27–53.Google Scholar
86 Ebmeier, KP, Calder, SA, Crawford, JR et al. Dementia in idiopathic Parkinson's disease: prevalence and relationship with symptoms and signs of Parkinsonism. Psychol Med 1991; 21: 69–76.Google Scholar
87 Breteler, MMB, de Groot, RRM, van Romunde, LKJ, Hofman, A. Risk of dementia for patients with Parkinson's disease, epilepsy, and severe head trauma: a register based follow-up study. Neurology 1993; 43: A172.Google Scholar
88 Growdon, JH, Corkin, S, Rosen, TJ. Distinctive aspects of cognitive dysfunction in Parkinson's disease. In: Streiffler, MB, Korczyn, AD, Melamed, E, Youdim, MBH eds. Advances in neurology, Volume 53: Parkinson's disease: anatomy, pathology, and therapy. New York: Raven Press, 1990: 365–76.Google Scholar
89 Starkstein, SE, Robinson, RG. Dementia of depression in Parkinson's disease and stroke. J Nerv Ment Dis 1991; 179: 593–601.Google Scholar
90 Langston, JW, Tetrud, JW. MPTP-induced Parkinsonism in humans: new insights into Parkinson's disease. In: Kennard, C ed. Recent advances in clinical neurology. London: Churchill Livingston, 1988: 153–73.Google Scholar
91 Bonita, R. Epidemiology of stroke. Lancet 1992; 339: 342–44.CrossRefGoogle ScholarPubMed
92 Tatemichi, TK, Desmond, DW, Paik, M et al. Clinical determinants of dementia related to stroke. Ann Neurol 1993; 33: 568–75.Google Scholar
93 Kase, CS. Epidemiology of multi-infarct dementia. Alzheimer Dis Assoc Disord 1991; 5: 71–76.Google Scholar
94 Román, GC, Tatemichi, TK, Erkinjuntti, T et al. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN international workshop. Neurology 1993; 43: 250–60.Google Scholar
95 Chui, HC, Victoroff, JI, Margolin, D et al. Criteria for the diagnosis of ischaemic vascular dementia proposed by the State of California Alzheimer's Disease Diagnostic and Treatment Centers. Neurology 1992; 42: 473–80.Google Scholar
96 Drachman, DA. New criteria for the diagnosis of vascular dementia. Neurology 1993: 43: 243–45.Google Scholar
97 Hachinski, V. Vascular dementia: a radical redefinition. Dementia 1994; 5: 130–32.Google Scholar
98 Chancellor, AM, Warlow, CP. Adult onset motor neuron disease: worldwide mortality, incidence and distribution since 1950. J Neurol Neurosurg Psychiatry 1992; 55: 1106–15.Google Scholar
99 Tanner, CM, Langston, JW. Do environmental toxins cause Parkinson's disease? A critical review. Neurology 1990; 40 (suppl 3): 17–30.Google Scholar
100 Chancellor, AM, Slattery, JM, Fraser, H, Warlow, CP. Risk factors for motor neuron disease: a case–control study based on patients from the Scottish Motor Neuron Disease Register. J Neurol Neurosurg Psychiatry 1993; 56: 1200–206.Google Scholar
101 Friedland, RP. Epidemiology, education, and the ecology of Alzheimer's disease. Neurology 1993; 43: 246–49.Google Scholar
102 Katzman, R. Education and the prevalence of dementia and Alzheimer's disease. Neurology 1993; 43: 13–20.Google Scholar
103 Mortimer, JA, Graves, AB. Education and other socioeconomic determinants of dementia and Alzheimer's disease. Neurology 1993; 43 (suppl 4): S39–S44.Google Scholar
104 Boniauto, S, Rocca, WA, Lippi, A et al. Impact of education and occupation on the prevalence of Alzheimer's disease (AD) and multi-infarct dementia (MID) in Appignano, Macerata province, Italy [Abstract]. Neurology 1990; 40 (suppl 1): 346.Google Scholar
105 Hill, LR, Klauber, MR, Salmon, DP et al. Functional status, education, and the diagnosis of dementia in the Shanghai study. Neurology 1993; 43: 138–45.Google Scholar
106 Dartigues, J-F, Gagnon, M, Mazaux, JM et al. Occupation during life and memory performance in nondemented French elderly community residents. Neurology 1992; 42: 1697–701.Google Scholar
107 Beard, CM, Kokmen, E, Offord, KP, Kurland, LT. Lack of association between Alzheimer's disease and education, occupation, marital status, or living arrangement. Neurology 1992; 42: 2063–68.Google Scholar
108 Prince, M, Cullen, M, Mann, A. Risk factors for Alzheimer's disease and dementia: a case–control study based on the MRC elderly hypertension trial. Neurology 1994; 43: 97–104.Google Scholar
109 O'Connor, DW, Pollitt, PA, Treasure, FP. The influence of education and social class on the diagnosis of dementia in a community population. Psychol Med 1991; 21: 219–24.Google Scholar
110 Popovitch, ER, Wisniewski, HM, Barcikowska, M et al. Alzheimer neuropathology in non-Down's syndrome mentally retarded adults. Acta Neuropathol 1990; 80: 362–67.Google Scholar
111 Jorm, AF, Henderson, AS, Scott, R et al. Does education protect against cognitive impairment? A comparison of the elderly in two Australian cities. Int J Geriatr Psychiatry 1994; 9: 357–63.Google Scholar
112 Baltes, PB, Sowarka, D, Kliegl, R. Cognitive training research on fluid intelligence in old age: what can older adults achieve by themselves? Psychol Aging 1989; 4: 217–21.Google Scholar
113 Christensen, H, Henderson, AS. Is age kinder to the initially more able? A study of eminent scientists and academics. Psychol Med 1991; 21: 935–46.Google Scholar
114 van Duijn, CM, Hofman, A. Risk factors of Alzheimer's disease: the EURODEM collaborative re-analysis of case–control studies. Neuroepidemiology 1992; 11 (suppl 1): 106–13.Google Scholar
115 van Duijn, CM, Clayton, D, Chandra, V et al. Familial aggregation of Alzheimer's disease and related disorders: a collaborative re-analysis of case–control studies. Int J Epidemiol 1991; 20 (suppl 2): S13–20 (for the EURODEM Risk Factors Research Group).Google Scholar
116 Duvoisin, RC. The genetics of Parkinson's disease. Adv Neurol 1993; 60: 306–15.Google Scholar
117 Williams, DB, Floate, DA, Leicester, J. Familial motor neuron disease: differing penetrance in large pedigrees. J Neurol Sci 1988; 86: 215–30.Google Scholar
118 Mendez, MF, Underwood, KL, Zander, BA et al. Risk factors in Alzheimer's disease: a clinico-pathologic study. Neurology 1992; 42: 770–75.Google Scholar
119 Roberts, GW, Gentleman, SM, Lynch, A et al. β-Amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease. J Neurol Neurosurg Psychiatry 1994; 57: 419–25.Google Scholar
120 Semchuk, KM, Love, EJ, Lee, RG. Parkinson's disease: a test of the multifactorial etiologic hypothesis. Neurology 1993; 43: 1173–80.Google Scholar
121 Harrington, CR, Wischik, CM, McArthur, FK et al. Alzheimer's-disease-like changes in tau protein processing: association with aluminium accumulation in brains of renal dialysis patients. Lancet 1994; 343: 993–97.Google Scholar
122 Doll, R. Alzheimer's disease and environmental aluminium [Review]. Age Ageing 1993; 22: 138–53.Google Scholar
123 Rifat, SL. Aluminium hypothesis lives. Lancet 1994; 343: 3–4.Google Scholar
124 Brenner, DE, Kukull, WA, van Belle, G et al. Relationship between cigarette smoking and Alzheimer's disease in a population-based case–control study. Neurology 1993; 43: 292–300.Google Scholar
125 Breteler, MMB, Claus, JJ, Grobbee, DE, Hofman, A. Cardiovascular disease and the distribution of cognitive function in an elderly population: the Rotterdam study. Br Med J 1994; 308: 1604–608.Google Scholar
126 Breteler, MMB, Bots, ML, Mosterd, A et al. Atherogenic and hemostatic factors and cognitive function in the elderly. The Rotterdam Study. In: Breteler, MMB ed. Cognitive decline in the elderly. Epidemiological studies on cognitive function and dementia. Rotterdam: Erasmus University, 1993: 74–85.Google Scholar
127 Breteler, MMB, Grobbee, DE, Hofman, A. Blood pressure, orthostatic hypotension, and cognitive function in the elderly. The Rotterdam study. Ann Neurol 1993; 34: A260–1.Google Scholar
128 Breteler, MMB, van Swieten, JC, Bots, ML et al. Cerebral white matter lesions, vascular risk factors and cognitive function in a population-based study: the Rotterdam Study. Neurology 1994; 44: 1246–52.Google Scholar
129 Crook, TH, Bartus, RT, Ferris, SH et al. Age- associated memory impairment: proposed diagnostic criteria and measures of clinical change–report of a National Institute of Mental Health Work Group. Dev Neuropsychol 1986; 2: 126–76.Google Scholar
130 Smith, G, Malec, JF, Petersen, RC et al. Age-Associated Memory Impairment diagnoses: problems of reliability and concerns for terminology. Psychol Aging 1991; 6: 551–58.Google Scholar
131 Barker, A, Jones, R. Age-associated memory impairment: diagnostic and treatment issues. Int J Geriatr Psychiatry 1993; 8: 305–10.Google Scholar
132 Larrabee, GJ, Crook, TH. Estimated prevalence of age-associated memory impairment derived from standardized tests of memory function. Int Psychogeriatr 1994; 6: 95–104.CrossRefGoogle ScholarPubMed
133 American Psychiatric Association. Diagnostic and statistical manual of mental disorders, fourth edition. Washington, DC: American Psychiatric Association, 1994.Google Scholar
134 World Health Organization. The ICD-10 classification of mental and behavioural disorders. Clinical descriptions and diagnostic guidelines. Geneva: World Health Organization, 1993.Google Scholar
135 Levy, R. Report: aging-associated cognitive decline. Working Party of IPA in collaboration with WHO. Int Psychogeriatr 1994; 6: 63–68.Google Scholar
136 Bolla, KI, Lindgren, KM, Bonaccorsy, C, Bleecker, ML. Memory complaints in older adults. Arch Neurol 1991; 48: 61–64.Google Scholar
137 Christensen, H. The validity of memory complaints by elderly persons. Int J Geriatr Psychiatry 1991; 6: 307–12.Google Scholar
138 O'Connor, DW, Pollitt, PA, Roth, M et al. Memory complaints and impairment in normal, depressed and demented elderly people identified in a community sample. Arch Gen Psychiatry 1990; 47: 224–27.Google Scholar
139 Grut, M, Jorm, AF, Fratiglioni, L et al. Memory complaints of elderly people in a population survey: variation according to dementia stage and depression. J Am Geriatr Soc 1993; 41: 1295–1300.Google Scholar
140 O'Brien, JT, Beats, B, Hill, K et al. Do subjective memory complaints precede dementia? A three-year follow up of patients with supposed ‘benign senescent forgetfulness’. Int J Geriatr Psychiatry 1992; 7: 481–86.Google Scholar
141 Flicker, C, Ferris, SH, Reisberg, B. A longitudinal study of cognitive function in elderly persons with subjective memory complaints. J Am Geriatr Soc 1993; 41: 1029–32.Google Scholar
142 Fuhrer, R, Antonucci, TC, Gagnon, M et al. Depressive symptomatology and cognitive functioning: an epidemiological survey in an elderly community sample in France. Psychol Med 1992; 22: 159–72.Google Scholar
143 McGlone, J, Gupta, S, Humphrey, D et al. Screening for early dementia using memory complaints from patients and relatives. Arch Neurol 1990; 46: 1189–93.Google Scholar
144 Henderson, AS. Co-occurrence of affective and cognitive symptoms: the epidemiological evidence. Dementia 1990; 1: 119–23.Google Scholar
145 Brayne, C. Clinicopathological studies of the dementias from an epidemiological viewpoint. Br J Psychiatry 1993; 162: 439–46.Google Scholar
146 Ritchie, K, Ledesert, B, Touchon, J. The Eugeria study of cognitive ageing: who are the ‘normal’ elderly? Int J Geriatr Psychiatry 1994 (in press).Google Scholar