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Disorders of the liver, gall bladder and pancreas

Published online by Cambridge University Press:  17 November 2008

D O'Shea  and
HA Wynne
D O'Shea
Affiliation:
Royal Victoria Infirmary, Newcastle upon Tyne, UK
HA Wynne*
Affiliation:
Royal Victoria Infirmary, Newcastle upon Tyne, UK
*
Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NEI 4LP, UK.
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Abstract

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Type
Clinical geriatrics
Information
Reviews in Clinical Gerontology , Volume 6 , Issue 3 , August 1996 , pp. 231 - 240
Copyright
Copyright © Cambridge University Press 1996

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References

1Calloway, NO, Foley, GF, Lagerbloom, O. Uncertainties in geriatric data. J Am Geriatr Soc 1965; 13: 20–28.CrossRefGoogle ScholarPubMed
2Wynne, HA, Cope, LH, Mutch, E, Rawlins, MD, Woodhouse, KW, James, OFW. The effect of age upon liver volume and apparent liver blood flow in healthy man. Hepatology 1989; 9: 297–300.CrossRefGoogle ScholarPubMed
3Lubarsch, O, Hartman, PC, Osterveld, BJ, Thijssen, JM, Rosenbursch, GJ. Variability of quantitative echographic parameters of the liver: intra and interindividual spread, temporal and age-related effects. Ultrasound Med Biol 1991; 17: 857–67.Google Scholar
4Bachman, KD. Uber das Lipofuscin der Leber. Virch Arch 1953; 323: 133–42.CrossRefGoogle Scholar
5Braendstrup, O, Dombernorsky, P. The content of lipofuscin in liver biopsies from patients operated for gallstones. Acta Pathol Microbici Scand A 1970; 78: 565–70.Google ScholarPubMed
6Tauchi, H, Hananouchi, M, Sato, T. The accumulation of lipofuscin pigment in human hepatic cells from different races and in different environmental conditions. Mech Age Dev 1980; 12: 183–95.Google Scholar
7Fisman, M. Hepatic aging as an etiological factor in the development of Alzheimer's disease. Med Hypotheses 1990; 33: 163–67.Google Scholar
8Findor, J, Perez, V, Buich Igantia, E, Gio Banetti, M, Fiaravanti, N. Structure and ultrasound of the liver in aged persons. Acta Hepatogastroenterol 1973; 20: 200–204.Google Scholar
9Kudryavtser, BN, Kudryavtseva, MV, Sakuta, GA, Stein, GI. Human hepatocyte polyploidization kinetics in the course of life cycle. Virchows Arch B Cell Pathol 1993; 64: 387–93.Google Scholar
10Tauchi, H, Sata, T, Ito, Y. Morphological aspects of aging liver: half a century of progress in Japan. Arch Gerontol Geriatr 1994; 19: 135–44.Google Scholar
11Sata, T, Tauchi, H. The formation of enlarged and giant mitochondria in the aging process of human hepatic cells. Acta Pathol Jap 1975; 25: 403–12.Google Scholar
12Yen, TC, King, KL, Lee, HC, Yeh, SH, Wei, YH. Age dependent increase of mitochondrial DNA deletions together with lipid peroxides and Superoxide dismutase in human liver mitochondria. Free Radie Biol Med 1994; 16: 207–14.Google Scholar
13Riboni, L, Acquotti, D, Casellato, R et al. Changes of the human liver G(M3) ganglioside molecular species during aging. Eur J Biochem 1992; 203: 107–13.Google Scholar
14Gunaskera, JBL, Lee, DR, Jones, L, Maskrey, VL, Swift, CG, Jackson, SHD. Does serum albumin fall with increasing age in the absence of disease? Age Ageing 1996; 25 (suppl 1): 29.Google Scholar
15Williams, FM, Wynne, H, Woodhouse, KW, Rawlins, MD. Plasma aspirin esterase: the influence of old age and frailty. Age Ageing 1989; 18: 39–42.CrossRefGoogle ScholarPubMed
16Ratanasvanh, D, Beaune, P, Morel, F, Flinois, JP, Guengurch, FP, Guillouzo, A. Intra lobular distribution and quantification of cytochrome P-450 enzyme in human liver as a function of age. Hepatology 1991; 13: 1142–51.CrossRefGoogle Scholar
17Kenny, RAM, Hodkinson, HM, Prendiville, OF, Hayes, MC, Flynn, MD. Abnormalities of liver function tests in infection and outcome of acutely ill elderly patients. Age Ageing 1984; 13: 224–29.Google Scholar
18Marchesini, G, Bianchi, GP, Fabbri, A et al. Synthesis of urea after a protein-rich meal in normal man in relation to aging. Age Ageing 1990; 19: 4–10.CrossRefGoogle Scholar
19Marchesini, G, Bua, V, Brunori, A et al. Galactose elimination capacity and liver volume in aging man. Hepatology 1988; 8: 1079–83.CrossRefGoogle ScholarPubMed
20Schnegg, M, Lauterburg, BH. Quantitative liver function in the elderly assessed by galactose elimination capacity, antipyrine demethylation and caffeine clearance. J Hepatol 1986; 3: 164–71.Google Scholar
21Fabbri, A, Marchesini, G, Bianchi, G, Bugianesi, E, Zoli, M, Pisi, E. Kinetics of hepatic amino-nitrogen conversion in aging man. Liver 1994; 14: 288–94.CrossRefGoogle Scholar
22Broughton, DL, James, OFW, Alberti, KG, Taylor, R. Peripheral and hepatic insulin sensitivity in healthy elderly subjects. Eur J Clin Invest 1991; 21: 13–21.Google Scholar
23Williamson, J, Chopin, JM. Adverse reactions to prescribed drugs in the elderly. A multicentre investigation. Age Ageing 1980; 9: 73–80.CrossRefGoogle ScholarPubMed
24Wynne, HA, Goudevenous, J, Rawlins, MD, James, OFW, Adams, PC, Woodhouse, KW. Hepatic drug clearance: the effect of age using indocyanine green as a model compound. Br J Clin Pharmacol 1990; 30: 634–37.Google Scholar
25Wynne, H, Cope, L, Mutch, E, Rawlins, MD, Woodhouse, KW, James, OFW. The effect of age upon liver size and liver blood flow in man. Hepatology 1989; 9: 297–301.Google Scholar
26Wynne, H, Cope, L, Kelly, P, Whittingham, T, Edwards, C, Kamali, F. The influence of age, liver size and enantiomer concentrations on warfarin requirements. Br J Clin Pharmacol 1995; 40: 203–207.Google Scholar
27Schmucker, DC. Ageing and drug disposition. An update. Pharmacol Rev 1985; 37: 133–48.Google Scholar
28Woodhouse, KW, Mutch, E, Williams, FM, James, OFW. The effect of age on pathways of drug metabolism in human liver. Age Ageing 1984; 13: 328–34.CrossRefGoogle ScholarPubMed
29Hunt, CM, Westerkam, WR, Stave, GM. Effect of age and gender on the activity of human hepatic CYP 3A. Biochem Pharmacol 1992; 44: 275–83.CrossRefGoogle Scholar
30Wynne, H, Mutch, E, James, OFW, Wright, P, Rawlins, MD, Woodhouse, KW. The effect of age upon the affinity of microsomal monooxygenase enzymes for substrate in human liver. Age Ageing 1988; 17: 401–405.CrossRefGoogle ScholarPubMed
31Schmucker, DL, Woodhouse, KW, Wang, RK et al. Intrinsic age or gender-related alterations in human hepatic, microsomal monooxygenases: fact or fiction? In: Kitani, K ed. Liver and ageing. Amsterdam: Elsevier Science Publishers, 1990: 33–41.Google Scholar
32Yelland, C, Summerbell, J, Nicholason, E, Herd, B, Wynne, H, Woodhouse, KW. The association of age with aspirin esterase activity in human liver. Age Ageing 1991; 20: 16–18.CrossRefGoogle ScholarPubMed
33Herd, B, Wynne, H, Wright, P, James, O, Woodhouse, K. The effect of age on glucuronidation and sulphation of paracetamol by human liver fractions. Br J Clin Pharmacol 1991; 32: 768–70.Google Scholar
34Wynne, HA, Cope, LH, Herd, B, Rawlins, MD, James, OFW, Woodhouse, KW. The effect of age and frailty upon paracetamol conjugation in man. Age Ageing 1990; 19: 419–24.CrossRefGoogle Scholar
35Lieber, CS. Interaction of alcohol with other drugs and nutrients. Drugs 1990; 40 (suppl 3): 23–44.Google Scholar
36Lieber, CS. Mechanism of ethanol induced hepatic injury. Pharmacol Ther 1990; 46: 1–41.CrossRefGoogle ScholarPubMed
37Chambers, GK. The genetics of human alcohol metabolism. Gen Pharmacol 1990; 21: 267–72.CrossRefGoogle ScholarPubMed
38Kim, RB, O'Shea, D, Wilkinson, GR. Interindividual variability of 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms. Clin Pharmacol Ther 1995; 57: 645–55.CrossRefGoogle ScholarPubMed
39Wynne, HA, Wood, P, Herd, B, Wright, P, Rawlins, MD, James, OFW. The association of age with the activity of alcohol dehydrogenase in human liver. Age Ageing 1992; 21: 417–20.Google Scholar
40Potter, JF, James, OFW. Clinical features and prognosis of alcoholic liver disease in respect of advancing age. Gerontology 1987; 33: 380–87.CrossRefGoogle ScholarPubMed
41Chedid, A, Mendenhall, CL, Garside, P, French, SW, Chen, T, Rabin, L. Prognostic factors in alcoholic liver disease. Am J Gastroenterol 1991; 82: 210–16.Google Scholar
42Carithers, RL, Herlong, HF, Dichl, AN et al. Methylprednisolone therapy in patients with severe alcoholic hepatitis: a randomized multicenter trial. Ann Intern Med 1989; 110: 685–90.CrossRefGoogle ScholarPubMed
43Watson, RGP, Angus, PW, Dewar, M et al. , Low prevalence of primary biliary cirrhosis in Victoria, Australia. Gut 1995; 36: 927–30.CrossRefGoogle ScholarPubMed
44Myszor, M, James, OFW. The epidemiology of primary biliary cirrhosis in North East England: an increasingly common disease. Q J Med 1990; 276: 377–85.Google Scholar
45Metcalf, JV, James, OFW. Descriptive epidemiology of primary biliary cirrhosis (PBC): possible lessons for future transplantation requirements in Britain. Age Ageing 1996 (in press).Google Scholar
46O'Shea, D, James, OFW, Metcalf, JV. Are we missing primary biliary cirrhosis (PBC)? Does it matter anyway? Age Ageing 1996 (in press).Google Scholar
47Roll, J, Boyer, JL, Barry, D, Klatskin, G. The prognostic importance of clinical and histologic features in asymptomatic and symptomatic primary biliary cirrhosis. N Engl J Med 1983; 308: 1–7.CrossRefGoogle ScholarPubMed
48Lehmann, AB, Bassendine, MF, James, OFW. Is primary biliary cirrhosis a different disease in the elderly? Gerontology 1985; 31: 186–94.CrossRefGoogle ScholarPubMed
49Sherlock, S. Primary biliary cirrhosis. In: Sherlock, S ed. Diseases of the liver and biliary system, eighth edition. Oxford: Blackwell, 1989: 273–88.Google Scholar
50Kahng, KU, Roslyn, JJ. Surgical issues for the elderly patient with hepatobiliary disease. Surg Clin North Am 1994; 74: 345–73.CrossRefGoogle ScholarPubMed
51Friedman, GD, Kannel, WB, Dawber, TR. The epidemiology of gallbladder disease: Observations in the Framingham study. Chron Dis 1966; 19: 273–92.Google Scholar
52Heaton, KW. The epidemiology of gallstones and suggested aetiology. Clin Gastroenterol 1973; 2: 67–83.Google Scholar
53Bruckstein, AH. Nonsurgical management of cholelithiasis. Arch intern Med 1990; 150: 960–64.Google Scholar
54Glenn, F. Surgical management of acute cholecystitis in patients 65 years of age and older. Ann Surg 1981; 193: 56–59.Google Scholar
55Gracie, WA, Ranshoff, DF. The natural history of silent gallstones: the innocent gallstone is not a myth. N EnglJ Med 1982; 307: 798–800.Google Scholar
56Ranshoff, DF, Gracie, WA, Wolfsen, LB, Neuhauser, D. Prophylactic cholecystectomy or expectant management for silent gallstones: a decision analysis. Ann Intern Med 1983; 99: 199–204.Google Scholar
57Krasman, ML, Gracie, WA, Strasius, SR. Biliary tract disease in the elderly. Clin Geriatr Med 1991; 7: 347–70.Google Scholar
58Trotman, BW, Petrella, EJ, Soloway, RD. Evaluation of radiographie lucency or opaqueness of gallstones as a means of identifying cholesterol or pigment stones. Gastroenterology 1975; 68: 1563–66.Google Scholar
59Whiting, MJ, Bradley, BM, Watts, JM. Chemical and physical properties of gall stones in South Australia; Implications for dissolution therapy. Gut 1983; 24: 11–15.CrossRefGoogle Scholar
60Podda, M, Zuin, M, Battezzati, PM. Efficacy and safety of a combination of chenodeoxycholic and ursodeoxycholic acid for gallstone dissolution: a comparison with ursodeoxycholic acid alone. Gastroenterology 1989; 96: 222–29.CrossRefGoogle ScholarPubMed
61O'Donnell, LD, Heaton, KW. Recurrence and rerecurrence of gallstones after medical dissolution: a longterm follow up. Gut 1988; 29: 655–58.Google Scholar
62Salen, G. Gallstone dissolution therapy with ursodiol: efficacy and safety. Dig Dis Sci 1989; 34: 395–455.Google Scholar
63Villanova, N, Bazzoli, F, Taroni, F. Gallstone recurrence after successful oral bile acid treatment. Gastroenterology 1989; 97: 726–31.Google Scholar
64Logan, GM, Duane, WC. Lovastatin added to ursodeoxycholic acid further reduces biliary cholesterol saturation. Gastroenterology 1990; 98: 1572–76.CrossRefGoogle ScholarPubMed
65Duane, WC, Hunninghake, DB, Freeman, ML. Simvastatin, a competitive inhibitor of HMG-CoA reductase lowers cholesterol saturation index of gallbladder bile. Hepatology 1988; 8: 1147–50.CrossRefGoogle ScholarPubMed
66Magnuson, TH, Lillemoe, KD, Pitt, HA. How many Americans will be eligible for lithotripsy? Arch Surg 1989; 124: 1195–99.CrossRefGoogle Scholar
67Sackman, M, Delius, M, Sauerbach, T. Shock wave lithotripsy of gallbladder stones: the first 175 patients. N Engl Med 1988; 318: 393–97.Google Scholar
68Albert, MB, Fromm, H. US multicenter study of safety and efficacy in treating gallstones with piezoelectric lithotripsy [abstract]. Gastroenterology 1990; 98: A564.Google Scholar
69Thistle, JF, May, GR. Dissolution of cholesterol gallstones by methyl tert-butyl ether administered by percutaneous transhepatic catheter. N Engl J Med 1989; 320: 633–39.Google Scholar
70Nenner, RP, Imperato, PJ, Alcorn, CM. Complications of laparoscopie cholecystectomy in a geriatric population group. Ny State J Med 1992; 92: 518–20.Google Scholar
71Fried, GM, Clas, D, Meakins, JL. Minimally invasive surgery in the elderly patient. Surg Clin North Am 1994; 74: 375–87.CrossRefGoogle ScholarPubMed
72Rosyln, JJ, Binns, GS, Hughes, EF et al. Open cholecystectomies. A contemporary analysis of 42 474 patients. Ann Surg 1993; 218: 129–37.CrossRefGoogle Scholar
73Ikeda, M, Sato, T, Morozumi, A et al. Morphological changes in the pancreas detected by screening ultrasonography in a mass survey, with special reference to main duct dilatation, cyst formation and calcification. Pancreas 1994; 9: 508–12.Google Scholar
74Vellas, B, Balas, D, Moreau, J et al. Exocrine pancreatic secretion in the elderly. Int J Pancreatol 1998; 3: 497–502.Google Scholar
75Gullo, L, Ventrucci, M, Naldoni, P, Pezzilli, R. Ageing and exocrine pancreatic function. J Am Geriatr Soc 1986; 34: 790–92.CrossRefGoogle ScholarPubMed
76Gumbiner, B, Polonsky, KS, Beltz, WF, Wallace, P, Brechtel, G, Funk, RI. Effects of aging on insulin secretion. Diabetes 1989; 38: 1549–56.Google Scholar
77Pacini, G, Beccaro, F, Valeri, A, Nozadini, R, Gepaldi, G. Reduced beta-cell secretion and insulin hepatic excretion in healthy elderly subjects. J Am Geriatr Soc 1990; 38: 128–39.Google Scholar
78Corfield, AP, Cooper, NJ, Williamson, RCN. Acute pancreatitis: a lethal disease of increasing incidence. Gut 1985; 26: 724–29.Google Scholar
79Guyan, PM, Urden, S, Braganza, JM. Heightened free radical activity in pancreatitis. Free Radic Biol Med 1990; 8: 347–54.Google Scholar