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An update on frailty diagnosis and management

Published online by Cambridge University Press:  19 July 2013

Andrew JB Deane*
Affiliation:
Elderly Care Department, Royal Victoria Infirmary, Newcastle upon Tyne, UK
Ahmed F Jaafar
Affiliation:
Elderly Care Department, Royal Victoria Infirmary, Newcastle upon Tyne, UK
*
Address for correspondence: Dr Andrew Deane, Elderly Care Department, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK. Email: [email protected]

Summary

Frailty as a clinical syndrome is becoming more widely recognized and current evidence shows the importance of early detection of pre-frail states with a potential for reversibility of poor outcomes. The purpose of this review is to present the latest literature on frailty since the last review in this journal in 2007, with a particular focus on interventions aimed at reversing the processes of frailty.

Type
Review Article
Copyright
Copyright © Cambridge University Press 2013 

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References

1Mitnitski, A, Mogilner, A, Rockwood, K. Accumulation of deficits as a proxy measure of aging. Scientific World J 2001; 1: 323–36.CrossRefGoogle ScholarPubMed
2Fried, LP, Tangen, CM, Walston, Jet al.Frailty in older adults: Evidence for a phenotype. J Gerontol A: Biol Sci Med Sci 2001; 3: 146.CrossRefGoogle Scholar
3Jaafar, AF, Heycock, R, George, J. Frailty – a clinical overview. Rev Clin Geront 2007; 17: 171–75.CrossRefGoogle Scholar
4Yassuda, MS, Lopes, A, Cachioni, Met al.Frailty criteria and cognitive performance are related: Data from the FIBRA study in Ermelino Matarazzo, Sao Paulo, Brazil. J Nutrition, Healt Aging 2012; 16: 5561.CrossRefGoogle ScholarPubMed
5Freiheit, EA, Hogan, DB, Eliasziw, Met al.Development of a frailty index for patients with coronary artery disease. J Am Geriatr Soc 2010; 58:1526–31.CrossRefGoogle ScholarPubMed
6Afilalo, J, Eisenberg, MJ, Morin, JFet al.Gait speed as an incremental predictor of mortality and major morbidity in elderly patients undergoing cardiac surgery. J Am Coll Cardiol 2010; 56: 1668–76.CrossRefGoogle ScholarPubMed
7Van Kan, GA, Rolland, Y, Andrieu, Set al.Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people: an international academy on nutrition and aging (IANA) task force. J Nutrition, Health Aging 2009; 13: 881–89.CrossRefGoogle Scholar
8Verghese, J, Holtzer, R, Lipton, RB, Wang, C. Mobility stress test approach to predicting frailty, disability, and mortality in high-functioning older adults. J Am Geriatr Soc 2012; 60: 1901–5.CrossRefGoogle ScholarPubMed
9Rolfson, DB, Majumdar, SR, Tsuyuki, RT, Tahir, A, Rockwood, K. Validity and reliability of the Edmonton Frail Scale. Age Ageing 2006; 35: 526–29.CrossRefGoogle ScholarPubMed
10Dasgupta, M, Rolfson, DB, Stolee, P, Borrie, MJ, Speechley, M. Frailty is associated with postoperative complications in older adults with medical problems. Archives Gerontol Geriatrics 2009; 48: 7883.CrossRefGoogle ScholarPubMed
11Farhat, JS, Velanovich, V, Falvo, AJet al.Are the frail destined to fail? Frailty Index as predictor of surgical morbidity and mortality in the elderly. J Trauma Acute Care Surgery 2011; 72: 1526–31.CrossRefGoogle Scholar
12Hubbard, RE, O'Mahony, MS, Savva, GM, Calver, BL, Woodhouse, KW. Inflammation and frailty measures in older people. J Cell Mol Med 2009; 13: 3103–9.CrossRefGoogle ScholarPubMed
13Rønning, B, Wyller, TB, Seljeflot, Iet al.Frailty measures, inflammatory biomarkers and post-operative complications in older surgical patients. Age Ageing 2010; 39: 758–61.CrossRefGoogle ScholarPubMed
14Ensrud, KE, Blackwell, TL, Cauley, JAet al.Osteoporotic Fractures in Men Study Group. Circulating 25-hydroxyvitamin D levels and frailty in older men: the osteoporotic fractures in men study. J Am Geriatr Soc 2011; 59: 101–6.CrossRefGoogle Scholar
15Shardell, M, Hicks, GE, Miller, RRet al.Association of low vitamin D levels with the frailty syndrome in men and women. J Gerontol A Biol Sci Med Sci 2009; 64A: 6975.CrossRefGoogle Scholar
16Sinha, A, Hollingsworth, KG, Ball, S, Cheetham, T. Improving the vitamin D status of vitamin D deficient adults is associated with improved mitochondrial oxidative function in skeletal muscle. J Clin Endocrinol Metab 2013; 98: E50913.CrossRefGoogle ScholarPubMed
17Schabitz, WR, Steigleder, T, Cooper-Kuhn, CMet al.Intravenous brain-derived neurotrophic factor enhances post-stroke sensorimotor recovery and stimulates neurogenesis. Stroke 2007; 38: 2165–72.CrossRefGoogle Scholar
18Ciammola, A, Sassone, J, Cannella, Met al.Low brain-derived neurotrophic factor (BDNF) levels in serum of Huntington's disease patients. Am J Med Genetics B: Neuropsychiatric Genetics 2007; 144B: 574–77.CrossRefGoogle ScholarPubMed
19Schindowski, K, Belarbi, K, Buee, L. Neurotrophic factors in Alzheimer's disease: role of axonal transport. Genes Brain Behaviour 2008; 7: 4356.CrossRefGoogle ScholarPubMed
20Krabbe, KS, Mortensen, EL, Pedersen, AN, Pedersen, BK, Jorgensen, T, Bruunsgaard, H. Brain-derived neurtotrophic factor predicts mortality risk in older women. J Am Geriatr Soc 2009; 57: 1447–52.CrossRefGoogle ScholarPubMed
21Coelho, FM, Pereira, DS, Lustosa, LPet al.Physical therapy intervention (PTI) increases plasma brain-derived neurotrophic factor (BDNF) levels in non-frail and pre-frail elderly women. Archives Gerontol Geriatrics 2012; 54: 415–20.CrossRefGoogle ScholarPubMed
22Romero-Ortuno, R, Walsh, CD, Lawlor, BA, Kenny, RA. A frailty instrument for primary care: findings from the Survey of Health, Ageing and Retirement in Europe (SHARE). BMC Geriatrics 2010; 10: 57. doi: 10.1186/1471-2318-10-57.CrossRefGoogle ScholarPubMed
24Boyle, PA, Buchman, AS, Wilson, RS, Leurgans, SE, Bennett, DA. Physical frailty is associated with incident mild cognitive impairment in community-based older persons. J Am Geriatr Soc 2010; 58: 248–55.CrossRefGoogle ScholarPubMed
25Avila-Funes, JA, Carcaillon, L, Helmer, Cet al.Is frailty a prodromal stage of vascular dementia? Results from the Three-City Study. J Am Geriatr Soc 2012; 60: 1708–12.CrossRefGoogle ScholarPubMed
26Di Bari, M, van de Poll-Franse, LV, Onder, Get al.Antihypertensive medications and differences in muscle mass in older persons: the Health, Aging and Body Composition Study. 2004. J Am Geriatr Soc 52: 961–66.CrossRefGoogle ScholarPubMed
27Sumukadas, D, Witham, MD, Struthers, AD, McMurdo, MET. Effect of perindopril on physical function in elderly people with functional impairment: a randomised controlled trial. 2007. Canadian Med Assoc J 2007; 177: 867–74.CrossRefGoogle Scholar
28Gray, SL, LaCroix, AZ, Aragaki, AKet al.Angiotensin-converting enzyme inhibitor use and incident frailty in women aged 65 and older: prospective findings from the Women's Health Initiative Observational Study. J Am Geriatr Soc 2009; 57: 297303.CrossRefGoogle ScholarPubMed
29Jacobsen, DE, Melis, RJ, Verhaar, HJ, Olde Rikkert, MG. Raloxifene and tibolone in elderly women: a randomized, double-blind, double-dummy, placebo-controlled trial. J Am Med Directors Assoc 2012; 13: 189.e17.CrossRefGoogle ScholarPubMed
30Kenny, AM, Boxer, RS, Kleppinger, A, Brindisi, J, Feinn, R, Burleson, JA. Dehydroepiandrosterone combined with exercise improves muscle strength and physical function in frail older women. J Am Geriatr Soc 2010; 58: 1707–14.CrossRefGoogle ScholarPubMed
31Kenny, AM, Kleppinger, A, Annis, Ket al.Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels, low bone mass, and physical frailty. J Am Geriatr Soc 2010; 58: 1134–43.CrossRefGoogle Scholar
32Basaria, S, Coviello, AD, Travison, TGet al.Adverse events associated with testosterone administration. N Engl J Med 2010; 363: 109–22.CrossRefGoogle ScholarPubMed
33Liu, H, Bravata, DM, Olkin, Iet al.Systematic Review: the safety and efficacy of growth hormone in the healthy elderly. Annals Internal Med 2007; 146: 104–15.CrossRefGoogle ScholarPubMed
34Nass, R, Pezzoli, SS, Oliveri, MCet al.Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Annals Internal Med 2008; 149: 601–11.CrossRefGoogle ScholarPubMed
35Li, CM, Chen, CY, Li, CY, Wang, WD, Wu, SC. The effectiveness of a comprehensive geriatric assessment intervention program for frailty in community-dwelling older people: a randomized, controlled trial. Archives Gerontol Geriatrics 2010; 50 suppl 1: S3942.CrossRefGoogle ScholarPubMed
36Monteserin, R, Brotons, C, Moral, Iet al.Effectiveness of a geriatric intervention in primary care: a randomized clinical trial. Family Practice 2010; 27: 239–45.CrossRefGoogle ScholarPubMed
37Fairhall, N, Sherrington, C, Kurrle, SE, Lord, SR, Lockwood, K, Cameron, ID. Effect of a mutifactorial interdisciplinary intervention on mobility related disability in frail older people: randomised controlled trial. BMC Medicine 2012; 10: 120.CrossRefGoogle Scholar
38Chan, DC, Tsou, HH, Yang, RSet al.A pilot randomized controlled trial to improve geriatric frailty. BMC Geriatrics 2012; 12: 58.CrossRefGoogle ScholarPubMed
39Gustafsson, S, Wilhelmson, K, Eklund, Ket al.Health-promoting interventions for persons aged 80 and older are successful in the short term – results from the randomized and three-armed Elderly Persons in the Risk Zone study. J Am Geriatr Soc 2012; 60: 447–54.CrossRefGoogle ScholarPubMed
40Schuurmans, H, Steverink, N, Lindenberg, SM, Frieswijk, N, Slaets, JPJ. Old or frail: what tells us more? J Geronotol Biol 2004; 59: 962–65.CrossRefGoogle ScholarPubMed
41Frieswijk, N, Steverink, N, Buunk, BP, Slaets, JP. The effectiveness of a bibliotherapy in increasing the self-management ability of slightly to moderately frail older people. Patient Educ Counsel 2006; 61: 219–27.CrossRefGoogle ScholarPubMed
42Tieland, M, van de, Rest O. Dirks MLet al.Protein supplementation improves physical performance in frail elderly people: a randomized, double-blind, placebo-controlled trial. J Am Med Directors Assoc 2012; 13: 720–26.CrossRefGoogle ScholarPubMed
43Tieland, M, Dirks, ML, van der Zwaluw, Net al.Protein supplementation increases muscle mass gain during prolonged resistance-type exercise training in frail elderly people: a randomized, double-blind, placebo-controlled trial. J Am Med Directors Assoc 2012; 13: 713–19.CrossRefGoogle ScholarPubMed
44Leenders, M, Verdijk, LB, Van der Hoeven, Let al.Protein supplementation during resistance-type exercise training in the elderly. Med Sci Sports Exerc 2013; 45: 542–52.CrossRefGoogle ScholarPubMed
45Singh, NA, Quine, S, Clemson, LMet al.Effects of high-intensity progressive resistance training and targeted multidisciplinary treatment of frailty on mortality and nursing home admissions after hip fracture: a randomized controlled trial. J Am Med Directors Assoc 2012; 13: 2430.CrossRefGoogle ScholarPubMed
46Gine-Garriga, M, Guerra, M, Pages, E, Manini, TM, Jimenez, R, Unnithan, VB. The effect of functional circuit training on physical frailty in frail older adults: a randomized controlled trial. J Aging Physical Activity 2010; 18: 401–24.CrossRefGoogle ScholarPubMed