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Integrins in the endometrium

Published online by Cambridge University Press:  03 June 2009

Bruce A Lessey  and
Arthur J Castelbaum
Bruce A Lessey*
Affiliation:
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Arthur J Castelbaum
Affiliation:
Northern Fertility and Reproduction, Abington, Pennsylvania, USA
*
CB#7570 MacNider Building, University of North Carolina, Chapel Hill, NC 27599, USA.
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The endometrium expresses many of the same integrins displayed by other tissues. Endometrial epithelial cells maintain the ‘classic’ epithelial integrins, including α2, α3, α6, and β4, while the stroma expresses the fibronectin receptor, α5β1. During the menstrual cycle, the endometrium undergoes dynamic changes in morphology in preparation for implantation. With these histological changes are concomitant alterations in integrin expression that appear to ‘frame’ the window of implantation, by the co-expression of glandular αvβ3 and α4β1 during days 20 to 24 of the menstrual cycle. The changes in integrin expression shift from epithelial to stroma predominance late in the menstrual cycle, extending into early pregnancy. Decidual integrins that appear upregulated in pregnancy include α1β1, α3β1, α6β1 and αvβ3. Markers of uterine receptivity hold promise for a better understanding of the implantation process and may help to explain many different types of infertility. These markers will be essential for monitoring and improving infertility therapies. The importance of integrins in the human endometrium now seems well established and promises to be an area of great clinical and basic science activity in the future.

Type
Articles
Information
Reproductive Medicine Review , Volume 4 , Issue 1 , March 1995 , pp. 43 - 58
Copyright
Copyright © Cambridge University Press 1995

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