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GnRH analogues in the treatment of fibroids

Published online by Cambridge University Press:  02 March 2009

Christine P West
Christine P West*
Affiliation:
University of Edinburgh, UK
*
Christine P West, Department of Obstetrics and Gynaecology, University of Edinburgh, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9EW, UK.
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Extract

Uterine fibroids are estimated to affect up to 25% of women of reproductive age and are a common cause of morbidity, being associated with menstrual dysfunction, iron deficiency anaemia, pregnancy wastage and subfertility. Their pathogenesis remains unknown but their association with ovarian function and oestrogen production is undisputed and supported by their occurrence only after puberty and the shrinkage observed after the menopause. This oestrogen dependency has recently been exploited therapeutically through investigation of the use of agents that induce a hypo-oestrogenic state, the gonadotrophin-releasing hormone (GnRH) or luteinizing hormone-releasing hormone (LHRH) analogues.

Type
Articles
Information
Reproductive Medicine Review , Volume 2 , Issue 3 , October 1993 , pp. 181 - 197
Copyright
Copyright © Cambridge University Press 1993

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