The sixteenth-century writer Ortensio Lando (ca. 1512–ca. 1553) wrote many of his works pseudonymously and borrowed liberally from the works of others. Part of a community of professional writers who experimented with collaborative modes of literary production, Lando was also deeply invested in the currents of religious reform that swept through sixteenth-century Italy. In his extensive literary recourse to female personas, Lando privileged contemporary women who shared his own heterodox religious views. This essay examines Lando's female impersonations with particular attention to his use of Lucrezia Gonzaga da Gazzuolo (ca. 1521–76), whose complex literary relationship with Lando is illustrated by her presence throughout his literary corpus, and by his role in the book of Lettere published under her name. It argues that the relationship between these two figures can be best understood as a literary and spiritual partnership, one that meshed Lando's editorial expertise with Gonzaga's fame as a woman of extraordinary virtue and spiritual authority, a reputation that Lando himself helped to create. In an era when print publication by women was still far from common, such collaboration constituted an alternative path to literary expression.