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Pulmonary retention of actinidesafter dissolution of PuO2 aerosols:interest in modelling DTPA decorporation

Published online by Cambridge University Press:  12 June 2008

A.-L. Sérandour  and
P. Fritsch
A.-L. Sérandour
Affiliation:
Laboratoire de Radiotoxicologie, CEA/DSV/iRCM/SREIT, B.P. 12, 91680 Bruyères-le-Châtel, France.
P. Fritsch
Affiliation:
Laboratoire de Radiotoxicologie, CEA/DSV/iRCM/SREIT, B.P. 12, 91680 Bruyères-le-Châtel, France.
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Abstract

This study estimates in terms of amount and localisation the pulmonary retention of dissociated Pu/Am in the rat for the first week following an inhalation exposure to industrial PuO2 aerosols by combining standard biokinetic methods, quantitative analysis of contact autoradiograph obtained from lung section, and treatments by DTPA performed either in vivo or in vitro. The dissociated actinides mainly involved dissolved forms which are homogeneously distributed within lung parenchyma. Most of these chemical forms appears to come from the fraction (fr) of radioelements which seems to dissolve before particles phagocytosis mainly by alveolar macrophages. Early pulmonary administration of dry diethylenetriaminepentaacetic acid (DTPA) powder (+2 hours) decorporates ~90% of these actinide forms, whereas, a delayed treatment (+1 week) is far less efficient. By contrast, a similar extraction (~90%) of the dissolved actinides from lung sections of rat untreated by the chelating agent is measured after their incubation in a DTPA solution for both 2 hours and 7 days post-exposure times. These results can be explained by a gradual internalisation of a fraction of the early dissolved actinides (mainly Am) in alveolar cells, but not preferentially in alveolar macrophages, whereas the remaining fraction of dissolved actinides are transferred to blood. From these observations, a new model is proposed to help for interpretation of human bioassay data obtained after internal contamination and DTPA treatments.

Keywords

PuO2 aerosolsdissolution parametersbound fractionDTPAmodelling
Type
Research Article
Information
Radioprotection , Volume 43 , Issue 2 , April 2008 , pp. 239 - 253
Copyright
© EDP Sciences, 2008

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References

André, S., Charuau, J., Rateau, G., Vavasseur, C., Métivier, H. (1989) Design of a new inhalation device for rodents and primates, J. Aerosol. Sci. 6, 647-656. CrossRef
Birchall A., Bailey M.R., Jarvis N.S. (1995) Application of the new ICRP respiratory tract model to inhaled plutonium nitrate using experimental biokinetic data. In: Proceedings of the international conference on radiation dose management in the nuclear industry, Windermere, UK, 9-11 October, 1995. pp. 216-223. British Nuclear Energy Society.
Cooper, J.R., Stradling, G.N. Smith, H., Breadmore, S.E. (1979) The reactions of 1.0 nanometre diameter plutonium-238 dioxide particles with rat lung fluid, Int. J. Radiat. Biol. 36, 453-466.
Diel, J.H., Mewhninney, J.A. (1983) Fragmentation of inhaled 238PuO2 particles in lung, Health Phys. 44, 135-143. CrossRef
Fleischer, R.L., Raabe, O.G. (1977) Fragmentation of respirable PuO2 in water by alpha decay: a mode of "dissolution", Health Phys. 32, 253-257. CrossRef
Fritsch P. (2007) The distribution of the number of alpha hits per target cell: a new parameter to improve risk assessment for cancer induction using ICRP models, Radiat. Prot. Dosim. DOI: 10.1093/rpd/ncm466. CrossRef
Fritsch, P., Dudoignon, N., Guillet, K., Oghiso, Y., Morlier, J.P., Monchaux, G. (2003) Does mean lung dose calculated after inhalation of alpha emitters actually reflect the risk of induction of malignant lung tumour? Radiat. Prot. Dosim. 105, 149-152. CrossRef
Fritsch P., Grappin L., Guillermin A.M., Fottorino R., Ruffin M., Miele A. (2007) Modelling of bioassay data from a Pu wound treated by repeated DTPA perfusions: biokinetics and dosimetric approaches. Radiat. Prot. Dosim. DOI: 10.1093/rpd/ncm260. CrossRef
Gervelas, C., Sérandour, A.L., Geiger, S., Grillon, G., Fritsch, P., Taulelle, C., Le Gall, B., Benech, H., Deverre, J.R., Fattal, E., Tsapis, N. (2007) Direct lung delivery of a dry powder formulation of DTPA with improved aerosolization properties: Effect on lung and systemic decorporation of plutonium, J. Control. Release 118, 78-86. CrossRef
Hahn, F.F., Romanov, S.A., Guilmette, R.A., Nifatov, A.P., Zaytseva, Y.V., Diel, J.H., Allen, S.W., Lyovkina, Y.V. (2003) Distribution of plutonium particles in the lungs of Mayak workers, Radiat. Prot. Dosim. 105, 81-84. CrossRef
Guilmette, R.A., Muggenburg, B.A. (1988) Reducing the radiation dose from inhaled americium-241 using continuously administered DTPA therapy, Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 53, 261-271. CrossRef
Guilmette, R.A., Griffith, W.C., Hickman, A.W. (1994) Intake assessment for workers who have inhaled 238Pu aerosols. Radiat. Prot. Dosim. 53, 127-131. CrossRef
ICRP Publication 30 (1979) Limits of intakes of radionuclides by workers, Ann. ICRP 2(3-4).
ICRP Publication 66 (1994) Human respiratory tract model for radiological protection, Ann. ICRP 24(1-3).
ICRP Supporting guidance 3 (2002) Guide for the practical application of the ICRP human respiratory tract model, Oxford: Pergamon Press, 32.
James A.C., Sasser L.B., Stuit D.B., Glover S.E., Carbaugh E.H. (2007) USTUR whole body case 0269: demonstrating effectiveness of I.V. Ca-DTPA for Pu, Radiat. Prot. Dosim. DOI: 10.1093/rpd/ncm473. CrossRef
Lataillade, G., Verry, M., Rateau, G., Métivier, H., Masse, R. (1995) Translocation of plutonium from rat and monkey lung after inhalation of industrial plutonium oxide and mixed uranium and plutonium oxide, Int. J. Radiat. Biol. 67, 373-380. CrossRef
Métivier H. (1997) Plutonium, "Toxiques nucléaires", P. Galle (Ed.). Masson, Paris, pp. 225-245.
Métivier, H., Masse, R., Rateau, G., Lafuma, J. (1980) Experimental study of respiratory contamination by a mixed oxide aerosol formed from the combustion of a plutonium magnesium alloy, Health Phys. 38, 769-776. CrossRef
Ramounet, B., Matton, S., Guezingar-Liebard, F., Abram, M.C., Rateau, G., Grillon, G., Fritsch, P. (2000) Comparative biokinetics of plutonium and americium after inhalation of PuO2 and mixed oxides (U, Pu)O2 in rat, Int. J. Radiat. Biol. 76, 215-222. CrossRef
Rateau-Matton, S., Ansoborlo, E., Hodgson, A. (2004) Comparative absorption parameters of Pu and Am from PuO2 and mixed oxide aerosols measured after in vitro dissolution test and inhalation in rats, Int. J. Radiat. Biol. 80, 777-785. CrossRef
Sato, H., Bulman, R.A., Takahashi, S., Kubota, Y. (1994) Effects of macromolecular chelating agents on the release of 239Pu and 59Fe from alveolar macrophages after phagocytic uptake of 239Pu-59Fe-iron hydroxide colloid, Health Phys. 66, 545-549. CrossRef
Sérandour A.L., Tsapis N., Gervelas C., Grillon G., Frechou M., Deverre J.R., Benech H., Fattal E., Fritsch P., Poncy J.L. (2007) Decorporation of plutonium by pulmonary administration of Ca-DTPA dry powder: a study in rat after lung contamination with different plutonium forms, Radiat. Prot. Dosim. DOI: 10.1093/rpd/ncm300. CrossRef
Stather, J.W., Stradling, G.N., Smith, H., Payne, S., James, A.C., Strong, J.C., Ham, S., Sumner, S., Bulman, R.A., Hodgson, A., Towndrow, C., Ellender, M. (1982) Decorporation of 238PuO2 from the hamster by inhalation of chelating agents, Health Phys. 42, 520-525.
Stradling, G.N., Loveless, B.W., Ham, G.J., Smith, H. (1978a) The biological solubility in the rat of plutonium present in mixed plutonium-sodium aerosols, Health Phys. 35, 229-235. CrossRef
Stradling, G.N., Ham, G.J., Smith, H., Cooper, J., Breadmore, S.E. (1978b) Factors affecting the mobility of plutonium-238 dioxide in the rat, Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 34, 37-47. CrossRef
Stradling, G.N., Stather, J.W., Sumner, S.A., Strong, J.C., Lennox, A.M., Ham, S.E. (1984) Decorporation of inhaled plutonium nitrate from hamsters using Zn-DTPA, Health Phys. 46, 919-924.