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Calcium movement in nerve fibres

Published online by Cambridge University Press:  17 March 2009

J. Requena  and
L. J. Mullins
J. Requena
Affiliation:
Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas (IVIC), Apartado 1827, Caracas 101, Venezuela, and Department of Biophysics, School of Medicine University of Maryland, Baltimore, Md., 21201, U.S.A.
L. J. Mullins
Affiliation:
Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas (IVIC), Apartado 1827, Caracas 101, Venezuela, and Department of Biophysics, School of Medicine University of Maryland, Baltimore, Md., 21201, U.S.A.
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Extract

Given the existence of a difference in electrical potential between the interior of a nerve cell and the media surrounding it, where the cytoplasm is some 70 mV negative (Hodgkin, 1958), it must be expected that any positively charged ion to which the cell membrane is permeable is more concentrated in the cell interior. For monovalent cations such as Na and divalent cations such as Ca and Mg this is not the case in the majority of the cells such as the squid giant axon. In other words, nerve cells maintain a lower intracellular concentration of these ions, as compared with their concentration in the extracellular fluid. For Mg, Ca and Na ions, this lower internal concentration must, in the steady state, be effected by some membrane based mechanism which consumes energy.

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 12 , Issue 3 , August 1979 , pp. 371 - 460
Copyright
Copyright © Cambridge University Press 1979

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