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Ca2+ and activation mechanisms in skeletal muscle

Published online by Cambridge University Press:  17 March 2009

Christopher C. Ashley ,
Ian P. Mulligan  and
Trevor J. Lea
Christopher C. Ashley
Affiliation:
University Laboratory of Physiology, Parks Road, Oxford OXi 3PT, UK
Ian P. Mulligan
Affiliation:
University Laboratory of Physiology, Parks Road, Oxford OXi 3PT, UK
Trevor J. Lea
Affiliation:
University Laboratory of Physiology, Parks Road, Oxford OXi 3PT, UK
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Extract

It has been known for a number of years that calcium ions play a crucial role in excitation-contraction (e-c) coupling (Sandow, 1952). The majority of the calcium required for this process is derived, at least in vertebrate striated muscle fibres, from discrete intracellular stores located at sites within the cell: the terminal cysternae (tc)/junctional SR of the sarcoplasmic reticulum (SR) (Fig. 1 a). These storage sites not only form a compartment that is distinct from the sarcoplasm of the fibre, but they are also closely associated with the contractile elements, the myofibrils. The SR release sites are activated following the spread of electrical activity (Huxley and Taylor, 1958) along the transverse (T) tubular system (Eisenberg and Gage, 1967; Adrian et al. 1969a, b; Peachey, 1973) from the surface membrane (Bm).

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 24 , Issue 1 , February 1991 , pp. 1 - 73
Copyright
Copyright © Cambridge University Press 1991

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