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Acetylcholine receptors

Published online by Cambridge University Press:  17 March 2009

H. P. Rang
H. P. Rang
Affiliation:
Department of Pharmacology, Medical and Biological Sciences Building, University of Southampton
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Extract

The idea that certain drugs and neurotransmitters produce their effects by combining with specific receptors was first clearly expressed by Langley (1905) on the basis of the selective and localized effect of nicotine on striated muscle fibres. In 1914, Langley published a paper in which the antagonism between ‘curari’ and nicotine was analysed and measured as the ratio by which the nicotine concentration had to be increased in order to produce a standard response in the presence of tubocurarine. It was clear that Langley had in mind the idea of competition between nicotine and curare for the receptor sites and it was surprising that he did not formulatethe theory quantitatively, particularly since Hill, working in Langley's laboratory in 1909, published a mathematical analysis of the action of nicotine on frog muscle giving kinetic and equilibrium equations based on the law of mass action, which could easily have been extended to give an account of competitive antagonism. Barger & Dale (1910) did not favour the idea of specific receptors for sympathomimetic amines.

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 7 , Issue 3 , July 1974 , pp. 283 - 399
Copyright
Copyright © Cambridge University Press 1974

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References

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