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Roles of electrostatic interaction in proteins

Published online by Cambridge University Press:  17 March 2009

Haruki Nakamura
Haruki Nakamura
Affiliation:
Protein Engineering Research Institute, Furuedai, Suita, Osaka 565. Japan
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Extract

Electrostatic effects play an essential role in specific molecular recognition and molecular assembly in many biologically important molecules. The specific electric field at the active site also regulates the catalytic reaction of a protein. Moreover, intramolecular or inter-subunit electrostatic interactions, such as saltbridges, hydrogen bonds, and charge-dipole interactions, are considered to work to stabilize protein molecules. Those electrostatic roles recently observed in proteins are reviewed with a description of the origins and principles of electrostatic forces, and analyses will be made using simple models to illuminate the physical basis.

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 29 , Issue 1 , February 1996 , pp. 1 - 90
Copyright
Copyright © Cambridge University Press 1996

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