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Ligand–receptor interactions: facts and fantasies

Published online by Cambridge University Press:  17 March 2009

Irving M. Klotz
Irving M. Klotz
Affiliation:
Department of Chemistry, Northwestern University, Evanston, IL 60201, U.S.A.
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Extract

Except when radiation participates, all biological activities involve contact interactions between constituent reactants. At the molecular level, if one of the participants is smaller than its complementary partner, the former is usually designated the ‘ligand’ and the latter the ‘receptor’. Thus in an enzyme–substrate complex, the substrate is the ligand, the enzyme is the receptor. In immunological interactions, the ligand is the hapten or antigen, the receptor is the immunoglobulin. Neurotransmitters or hormones are effector ligands when they are bound to receptor sites at synapses or on cell membranes.

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 18 , Issue 3 , August 1985 , pp. 227 - 259
Copyright
Copyright © Cambridge University Press 1985

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