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Identification of neural circuits underlying P300 abnormalities in schizophrenia

Published online by Cambridge University Press:  25 September 2001

BRIAN F. O'DONNELL ,
ROBERT W. McCARLEY ,
GEOFFREY F. POTTS ,
DEAN F. SALISBURY ,
PAUL G. NESTOR ,
YOSHIO HIRAYASU ,
MARGARET A. NIZNIKIEWICZ ,
JOHN BARNARD ,
ZI JEN SHEN  and
DAVID M. WEINSTEIN
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BRIAN F. O'DONNELL
Affiliation:
Department of Psychiatry, Harvard Medical School and Brockton VA Medical Center, Brockton, MA, USA Department of Psychology, University of Indiana, Bloomington, USA
ROBERT W. McCARLEY
Affiliation:
Department of Psychiatry, Harvard Medical School and Brockton VA Medical Center, Brockton, MA, USA McLean Hospital Cognitive Neuroscience Laboratory, Belmont, MA, USA
GEOFFREY F. POTTS
Affiliation:
Department of Psychiatry, Harvard Medical School and Brockton VA Medical Center, Brockton, MA, USA
DEAN F. SALISBURY
Affiliation:
Department of Psychiatry, Harvard Medical School and Brockton VA Medical Center, Brockton, MA, USA McLean Hospital Cognitive Neuroscience Laboratory, Belmont, MA, USA
PAUL G. NESTOR
Affiliation:
Department of Psychiatry, Harvard Medical School and Brockton VA Medical Center, Brockton, MA, USA Department of Psychology, University of Massachusetts, Boston, USA
YOSHIO HIRAYASU
Affiliation:
Department of Psychiatry, Harvard Medical School and Brockton VA Medical Center, Brockton, MA, USA
MARGARET A. NIZNIKIEWICZ
Affiliation:
Department of Psychiatry, Harvard Medical School and Brockton VA Medical Center, Brockton, MA, USA
JOHN BARNARD
Affiliation:
Department of Statistics, Harvard University, Cambridge, MA, USA
ZI JEN SHEN
Affiliation:
Department of Statistics, Harvard University, Cambridge, MA, USA
DAVID M. WEINSTEIN
Affiliation:
Department of Computer Science, University of Utah, Salt Lake City, USA
FRED L. BOOKSTEIN
Affiliation:
Institute of Gerontology, University of Michigan, Ann Arbor, USA
MARTHA E. SHENTON
Affiliation:
Department of Psychiatry, Harvard Medical School and Brockton VA Medical Center, Brockton, MA, USA McLean Hospital Cognitive Neuroscience Laboratory, Belmont, MA, USA
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Abstract

Event-related potentials (ERPs) provide a noninvasive method to evaluate neural activation and cognitive processes in schizophrenia. The pathophysiological significance of these findings would be greatly enhanced if scalp-recorded ERP abnormalities could be related to specific neural circuits and/or regions of the brain. Using quantitative approaches in which scalp-recorded ERP components are correlated with underlying neuroanatomy in schizophrenia, we focused on biophysical and statistical procedures (partial least squares) to relate the auditory P300 component to anatomic measures obtained from quantitative magnetic resonance imaging. These findings are consistent with other evidence that temporal lobe structures contribute to the generation of the scalp-recorded P300 component and that P300 amplitude asymmetry over temporal recording sites on the scalp may reflect anatomic asymmetries in the volume of the superior temporal gyrus in schizophrenia.

Keywords

Event-related potentialsP300MRINeuroanatomySchizophrenia
Type
Research Article
Information
Psychophysiology , Volume 36 , Issue 3 , May 1999 , pp. 388 - 398
Copyright
© 1999 Society for Psychophysiological Research

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