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Why was early therapeutic research on psychedelic drugs abandoned?

Published online by Cambridge University Press:  21 October 2021

Wayne Hall Open the ORCID record for Wayne Hall [Opens in a new window]
Wayne Hall*
Affiliation:
National Centre for Youth Substance Use Research and Queensland Alliance for Environmental Health Sciences, The University of Queensland, St Lucia, Australia
*
Author for correspondence: Wayne Hall, E-mail: [email protected]
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Abstract

Background

Advocates of the therapeutic use of psychedelic drugs have argued that a promising approach to treatment was prematurely abandoned in the 1960s primarily because of Richard Nixon's ‘War on Drugs’.

This paper (1) briefly describes research in the 1950s and 1960s in North America on the use of LSD to treat alcohol dependence, anxiety in terminal illness, and anxiety and depression; and (2) discusses the factors that led to its abandonment.

Method

An analysis of historical scholarship on psychedelic research in the 1950s, 1960s and 1970s in North America.

Results

Research on psychedelic drugs in psychiatry was abandoned for a number of reasons that acted in concert. A major factor was that clinical research on psychedelic drugs was caught up in the tighter regulation of pharmaceutical research after the Thalidomide disaster in 1963. Psychedelic drugs also presented special challenges for randomised, placebo-controlled clinical trials in the 1970s that were not as positive as the claims made by their advocates in the 1950s and 1960s. Clinical research became more difficult after 1965 when Sandoz ceased providing psychedelic drugs for research and their nonmedical use was prohibited in 1970.

Conclusions

The demise of psychedelic drug research was not solely due to the ‘War on Drugs’. It was hastened by tighter regulation of pharmaceutical research, the failure of controlled clinical trials to live up to the claims of psychedelic advocates, and the pharmaceutical industry's lack of interest in funding clinical trials.

Keywords

Early psychedelic treatment researchaddictionanxietydepressionreasons for abandonment
Type
Review Article
Information
Psychological Medicine , Volume 52 , Issue 1 , January 2022 , pp. 26 - 31
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Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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