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Visuospatial planning in unmedicated major depressive disorder and bipolar disorder: distinct and common neural correlates

Published online by Cambridge University Press:  20 May 2016

M. M. Rive ,
M. W. J. Koeter ,
D. J. Veltman ,
A. H. Schene  and
H. G. Ruhé
M. M. Rive*
Affiliation:
Program for Mood Disorders, Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
M. W. J. Koeter
Affiliation:
Program for Mood Disorders, Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
D. J. Veltman
Affiliation:
Department of Psychiatry, VU University medical center, Amsterdam, The Netherlands
A. H. Schene
Affiliation:
Program for Mood Disorders, Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands
H. G. Ruhé
Affiliation:
Program for Mood Disorders, Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Psychiatry, Mood and Anxiety Disorders, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
*
*Address for correspondence: M. M. Rive, Program for Mood Disorders, Department of Psychiatry, Academic Medical Center, University of Amsterdam, PA3-221, PO Box 22660, 1100 DD Amsterdam, The Netherlands. (Email: [email protected])
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Abstract

Background

Cognitive impairments are an important feature of both remitted and depressed major depressive disorder (MDD) and bipolar disorder (BD). In particular, deficits in executive functioning may hamper everyday functioning. Identifying the neural substrates of impaired executive functioning would improve our understanding of the pathophysiology underlying these disorders, and may eventually aid in discriminating between MDD and BD, which is often difficult during depression and remission. To date, mostly medicated MDD and BD subjects have been investigated, which may have influenced results. Therefore, we investigated executive functioning in medication-free depressed and remitted MDD and BD subjects.

Method

We used the Tower of London (ToL) visuospatial planning task to assess behavioural performance and blood oxygen-level dependent responses in 35 healthy controls, 21 remitted MDD, 23 remitted BD, 19 depressed MDD and nine depressed BD subjects.

Results

Visuospatial planning per se was associated with increased frontostriatal activity in depressed BD compared to depressed MDD. In addition, post-hoc analyses indicated that visuospatial planning load was associated with increased parietal activity in depressed compared to remitted subjects, and BD compared to MDD subjects. Task performance did not significantly differ between groups.

Conclusions

More severely affected, medication-free mood disorder patients require greater parietal activity to perform in visuospatial planning, which may be compensatory to maintain relatively normal performance. State-dependent frontostriatal hyperactivity during planning may be a specific BD characteristic, providing clues for further characterization of differential pathophysiology in MDD v. BD. This could potentially provide a biomarker to aid in the differentiation of these disorders.

Keywords

Bipolar disorderexecutive functioningfMRImajor depressive disordermood statevisuospatial planning
Type
Original Articles
Information
Psychological Medicine , Volume 46 , Issue 11 , August 2016 , pp. 2313 - 2328
Copyright
Copyright © Cambridge University Press 2016 

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References

Adler, CM, Holland, SK, Schmithorst, V, Tuchfarber, MJ, Strakowski, SM (2004). Changes in neuronal activation in patients with bipolar disorder during performance of a working memory task. Bipolar Disorders 6, 540–549.Google Scholar
Altshuler, LL, Post, RM, Mikalauskas, K, Rosoff, A, Leverich, S, Ackerman, L (1995). Antidepressant-induced mania and cycle acceleration: a controversy revisited. American Journal of Psychiatry 152, 1130–1138.Google Scholar
Alvarez, JA, Emory, E (2006). Executive function and the frontal lobes: a meta-analytic review. Neuropsychology Review 16, 17–42.Google Scholar
Baune, BT, Li, X, Beblo, T (2013). Short- and long-term relationships between neurocognitive performance and general function in bipolar disorder. Journal of Clinical and Experimental Neuropsychology 35, 759–774.Google Scholar
Baune, BT, Renger, L (2014). Pharmacological and non-pharmacological interventions to improve cognitive dysfunction and functional ability in clinical depression – a systematic review. Psychiatry Research 219, 25–50.Google Scholar
Bearden, CE, Glahn, DC, Monkul, ES, Barrett, J, Najt, P, Villarreal, V, Soares, JC (2006). Patterns of memory impairment in bipolar disorder and unipolar major depression. Psychiatry Research 142, 139–150.Google Scholar
Beblo, T, Sinnamon, G, Baune, BT (2011). Specifying the neuropsychology of affective disorders: clinical, demographic and neurobiological factors. Neuropsychology Review 21, 337–359.Google Scholar
Bell, EC, Willson, MC, Wilman, AH, Dave, S, Silverstone, PH (2005). Differential effects of chronic lithium and valproate on brain activation in healthy volunteers. Human Psychopharmacology 20, 415–424.Google Scholar
Blumberg, HP, Leung, H-C, Skudlarski, P, Lacadie, CM, Fredericks, CA, Harris, BC, Charney, DS, Gore, JC, Krystal, JH, Peterson, BS (2003). A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices. Archives of General Psychiatry 60, 601–609.Google Scholar
Blumberg, HP, Stern, E, Martinez, D, Ricketts, S, De Asis, J, White, T, Epstein, J, McBride, PA, Eidelberg, D, Kocsis, JH, Silbersweig, DA (2000). Increased anterior cingulate and caudate activity in bipolar mania. Biological Psychiatry 48, 1045–1052.CrossRefGoogle ScholarPubMed
Bonelli, RM, Kapfhammer, H-P, Pillay, SS, Yurgelun-Todd, DA (2006). Basal ganglia volumetric studies in affective disorder: what did we learn in the last 15 years? Review. Journal of Neural Transmission 113, 255–268. Google Scholar
Bora, E, Harrison, BJ, Davey, CG, Yücel, M, Pantelis, C (2012). Meta-analysis of volumetric abnormalities in cortico-striatal-pallidal-thalamic circuits in major depressive disorder. Psychological Medicine 42, 671–681.Google Scholar
Bora, E, Harrison, BJ, Yücel, M, Pantelis, C (2013). Cognitive impairment in euthymic major depressive disorder: a meta-analysis. Psychological Medicine 43, 2017–2026.Google Scholar
Borkowska, A, Rybakowski, JK (2001). Neuropsychological frontal lobe tests indicate that bipolar depressed patients are more impaired than unipolar. Bipolar Disorders 3, 88–94.CrossRefGoogle ScholarPubMed
Bourne, C, Aydemir, O, Balanze-Marinez, V, Bora, E, Brissos, S, Cavanagh, JTO, Clark, L, Cubukcuoglu, Z, Videira Dias, V, Dittmann, S, Ferrier, IN, Fleck, DE, Frangou, S, Gallagher, P, Jones, L, Kieseppa, T, Martínez-Arán, A, Melle, I, Moore, PB, Mur, M, Pfennig, A, Raust, A, Senturk, V, Simonse, C, Smith, DJ, Bio, DS, Soeiro-de-Souza, MG, Stoddart, SDR, Sundet, K, Szoke, A, Thompson, JM, Torrent, C, Zalla, T, Craddock, N, Andreassen, OA, Leboyer, M, Vieta, E, Bauer, M, Worhunsky, PD, Tzagarakis, C, Rogers, RD, Geddes, JR, Goodwin, GM (2013). Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis. Acta Psychiatrica Scandinavica 128, 149–162.Google Scholar
Clark, L, Sarna, A, Goodwin, GM (2005). Impairment of executive function but not memory in first-degree relatives of patients with bipolar I disorder and in euthymic patients with unipolar depression. American Journal of Psychiatry 162, 1980–1982.CrossRefGoogle Scholar
Daniel, BD, Montali, A, Gerra, ML, Innamorati, M, Girardi, P, Pompili, M, Amore, M (2013). Cognitive impairment and its associations with the path of illness in affective disorders: a comparison between patients with bipolar and unipolar depression in remission. Journal of Psychiatric Practice 19, 275–287.Google Scholar
Deckersbach, T, Rauch, SL, Buhlmann, U, Ostacher, MJ, Beucke, J-C, Nierenberg, AA, Sachs, G, Dougherty, DD (2008). An fMRI investigation of working memory and sadness in females with bipolar disorder: a brief report. Bipolar Disorders 10, 928–942.Google Scholar
Delvecchio, G, Fossati, P, Boyer, P, Brambilla, P, Falkai, P, Gruber, O, Hietala, J, Lawrie, SM, Martinot, J-L, McIntosh, AM, Meisenzahl, E, Frangou, S (2012). Common and distinct neural correlates of emotional processing in bipolar disorder and major depressive disorder: a voxel-based meta-analysis of functional magnetic resonance imaging studies. European Neuropsychopharmacology 22, 100–113.Google Scholar
De Ruiter, MB, Reneman, L, Boogerd, W, Veltman, DJ, Van Dam, FSAM, Nederveen, AJ, Boven, E, Schagen, SB (2011). Cerebral hyporesponsiveness and cognitive impairment 10 years after chemotherapy for breast cancer. Human Brain Mapping 32, 1206–1219.Google Scholar
Drevets, WC, Price, JL, Furey, ML (2008). Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression. Brain Structure & Function 213, 93–118.Google Scholar
Dunkin, JJ, Leuchter, AF, Cook, IA, Kasl-Godley, JE, Abrams, M, Rosenberg-Thompson, S (2000). Executive dysfunction predicts nonresponse to fluoxetine in major depression. Journal of Affective Disorders 60, 13–23.Google Scholar
Elliott, R (2003). Executive functions and their disorders. British Medical Bulletin 65, 49–59.Google Scholar
Elliott, R, Baker, SC, Rogers, RD, O'Leary, DA, Paykel, ES, Frith, CD, Dolan, RJ, Sahakian, BJ (1997). Prefrontal dysfunction in depressed patients performing a complex planning task: a study using positron emission tomography. Psychological Medicine 27, 931–942.CrossRefGoogle ScholarPubMed
Ernst, M, Nelson, EE, McClure, EB, Monk, CS, Munson, S, Eshel, N, Zarahn, E, Leibenluft, E, Zametkin, A, Towbin, K, Blair, J, Charney, D, Pine, DS (2004). Choice selection and reward anticipation: an fMRI study. Neuropsychologia 42, 1585–1597.CrossRefGoogle ScholarPubMed
Fitzgerald, PB, Srithiran, A, Benitez, J, Daskalakis, ZZ, Oxley, TJ, Kulkarni, J, Egan, GF (2008). An fMRI study of prefrontal brain activation during multiple tasks in patients with major depressive disorder. Human Brain Mapping 29, 490–501.Google Scholar
Forbes, EE, Hariri, AR, Martin, SL, Silk, JS, Moyles, DL, Fisher, PM, Brown, SM, Ryan, ND, Birmaher, B, Axelson, DA, Dahl, RE (2009). Altered striatal activation predicting real-world positive affect in adolescent major depressive disorder. American Journal of Psychiatry 166, 64–73.CrossRefGoogle ScholarPubMed
Frangou, S, Kington, J, Raymont, V, Shergill, SS (2008). Examining ventral and dorsal prefrontal function in bipolar disorder: a functional magnetic resonance imaging study. European Psychiatry 23, 300–308.Google Scholar
Funahashi, S (2001). Neuronal mechanisms of executive control by the prefrontal cortex. Neuroscience Research 39, 147–165.CrossRefGoogle ScholarPubMed
Ghaemi, SN, Boiman, EE, Goodwin, FK (2000). Diagnosing bipolar disorder and the effect of antidepressants: a naturalistic study. Journal of Clinical Psychiatry 61, 804–808.Google Scholar
Ghaemi, SN, Rosenquist, KJ, Ko, JY, Baldassano, CF, Kontos, NJ, Baldessarini, RJ (2004). Antidepressant treatment in bipolar versus unipolar depression. American Journal of Psychiatry 161, 163–165.Google Scholar
Gildengers, AG, Butters, MA, Chisholm, D, Anderson, SJ, Begley, A, Holm, M, Rogers, JC, Reynolds, CF, Mulsant, BH (2012). Cognition in older adults with bipolar disorder versus major depressive disorder. Bipolar Disorders 14, 198–205.Google Scholar
Goethals, I, Audenaert, K, Jacobs, F, Van de Wiele, C, Ham, H, Pyck, H, Vandierendonck, A, Van Heeringen, C, Dierckx, R (2005). Blunted prefrontal perfusion in depressed patients performing the Tower of London task. Psychiatry Research 139, 31–40.CrossRefGoogle ScholarPubMed
Goodwin, GM, Anderson, I, Arango, C, Bowden, CL, Henry, C, Mitchell, PB, Nolen, WA, Vieta, E, Wittchen, H-U (2008 a). ECNP consensus meeting. Bipolar depression. Nice, March 2007. European Neuropsychopharmacology 18, 535–549.Google Scholar
Goodwin, GM, Martínez-Arán, A, Glahn, DC, Vieta, E (2008 b). Cognitive impairment in bipolar disorder: neurodevelopment or neurodegeneration? An ECNP expert meeting report. European Neuropsychopharmacology 18, 787–793.CrossRefGoogle ScholarPubMed
Gotlib, IH, Joormann, J (2010). Cognition and depression: current status and future directions. Annual Review of Clinical Psychology 6, 285–312.Google Scholar
Gruber, S, Rathgeber, K, Bräunig, P, Gauggel, S (2007). Stability and course of neuropsychological deficits in manic and depressed bipolar patients compared to patients with major depression. Journal of Affective Disorders 104, 61–71.Google Scholar
Gruber, SA, Rogowska, J, Yurgelun-Todd, DA (2004). Decreased activation of the anterior cingulate in bipolar patients: an fMRI study. Journal of Affective Disorders 82, 191–201.Google Scholar
Hajek, T, Alda, M, Hajek, E, Ivanoff, J (2013). Functional neuroanatomy of response inhibition in bipolar disorders – Combined voxel based and cognitive performance meta-analysis. Elsevier Ltd Journal of Psychiatric Research 47, 1955–1966.Google Scholar
Haldane, M, Jogia, J, Cobb, A, Kozuch, E, Kumari, V, Frangou, S (2008). Changes in brain activation during working memory and facial recognition tasks in patients with bipolar disorder with Lamotrigine monotherapy. European Neuropsychopharmacology 18, 48–54.Google Scholar
Hamilton, M (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry 23, 56–62.Google Scholar
Hamilton, M (1967). Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology 6, 278–296.CrossRefGoogle ScholarPubMed
Harvey, P-O, Fossati, P, Pochon, J-B, Levy, R, Lebastard, G, Lehéricy, S, Allilaire, J-F, Dubois, B (2005). Cognitive control and brain resources in major depression: an fMRI study using the n-back task. NeuroImage 26, 860–869.Google Scholar
Hirschfeld, RMA, Lewis, L, Vornik, LA (2003). Perceptions and impact of bipolar disorder: how far have we really come? Results of the National depressive and Manic-Depressive Association 2000 Survey of individuals with bipolar disorder. Journal of Clinical Psychiatry 64, 161–174.Google Scholar
Jaeger, J, Berns, S, Uzelac, S, Davis-Conway, S (2006). Neurocognitive deficits and disability in major depressive disorder. Psychiatry Research 145, 39–48.Google Scholar
Jogia, J, Dima, D, Kumari, V, Frangou, S (2012). Frontopolar cortical inefficiency may underpin reward and working memory dysfunction in bipolar disorder. World Journal of Biological Psychiatry 13, 605–615.Google Scholar
Kaneda, Y (2009). Verbal working memory impairment in patients with current episode of unipolar major depressive disorder and in remission. Clinical Neuropharmacology 32, 346–347.Google Scholar
Kempton, MJ, Salvador, Z, Munafo, MR, Geddes, JR, Simmons, A, Frangou, S, Williams, SCR, With, C, Disorder, B (2011). Structural neuroimaging studies in major depressive disorder. Archives of General Psychiatry 68, 675–690.Google Scholar
Korgaonkar, MS, Grieve, SM, Etkin, A, Koslow, SH, Williams, LM (2013). Using standardized fMRI protocols to identify patterns of prefrontal circuit dysregulation that are common and specific to cognitive and emotional tasks in major depressive disorder: first wave results from the iSPOT-D study. Neuropsychopharmacology 38, 863–871.CrossRefGoogle ScholarPubMed
Kulkarni, S, Jain, S, Janardhan Reddy, YC, Kumar, KJ, Kandavel, T (2010). Impairment of verbal learning and memory and executive function in unaffected siblings of probands with bipolar disorder. Bipolar Disorders 12, 647–656.Google Scholar
Larson, ER, Shear, PK, Krikorian, R, Welge, J, Strakowski, SM (2005). Working memory and inhibitory control among manic and euthymic patients with bipolar disorder. Journal of the International Neuropsychological Society 11, 163–172.Google Scholar
Lazeron, RHC, Rombouts, SARB, Machielsen, WCM, Scheltens, P, Witter, MP, Uylings, HBM, Barkhof, F (2000). Visualizing brain activation during planning: the Tower of London test adapted for functional MR imaging. American Journal of Neuroradiology 21, 1407–1414.Google Scholar
Lim, CS, Baldessarini, RJ, Vieta, E, Yucel, M, Bora, E, Sim, K, Lim, SC (2013). Longitudinal neuroimaging and neuropsychological changes in bipolar disorder patients: review of the evidence. Neuroscience and Biobehavioral Reviews 37, 418–435.Google Scholar
Maldjian, J, Laurienti, P, Burdette, J (2004). Precentral gyrus discrepancy in electronic versions of the Talairach atlas. NeuroImage 21, 450–455.Google Scholar
Maldjian, J, Laurienti, P, Burdette, J, Kraft, R (2003). An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. NeuroImage 19, 1233–1239.Google Scholar
Marchand, WR, Yurgelun-Todd, D (2010). Striatal structure and function in mood disorders: a comprehensive review. Bipolar Disorders 12, 764–785.Google Scholar
Marquand, AF, Mourão-Miranda, J, Brammer, MJ, Cleare, AJ, Fu, CHY (2008). Neuroanatomy of verbal working memory as a diagnostic biomarker for depression. NeuroReport 19, 1507–1511.Google Scholar
Matsuo, K, Glahn, DC, Peluso, MAM, Hatch, JP, Monkul, ES, Najt, P, Sanches, M, Zamarripa, F, Li, J, Lancaster, JL, Fox, PT, Gao, J-H, Soares, JC (2007). Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder. Molecular Psychiatry 12, 158–166.Google Scholar
Martínez-Arán, A, Vieta, E, Reinares, M, Colom, F, Torrent, C, Sánchez-Moreno, J, Benabarre, A, Goikolea, JM, Comes, M, Salamero, M (2004). Cognitive function across manic or hypomanic, depressed, and euthymic states in bipolar disorder. American Journal of Psychiatry 161, 262–270.Google Scholar
McIntyre, RS, Cha, DS, Soczynska, JK, Woldeyohannes, HO, Gallaugher, LA, Kudlow, P, Alsuwaidan, M, Baskaran, A (2013). Cognitive deficits and functional outcomes in major depressive disorder: determinants, substrates, and treatment interventions. Depression and Anxiety 30, 515–527.Google Scholar
Miyake, A, Friedman, NP, Emerson, MJ, Witzki, AH, Howerter, A, Wager, TD (2000). The unity and diversity of executive functions and their contributions to complex ‘Frontal Lobe’ tasks: a latent variable analysis. Cognitive Psychology 41, 49–100.Google Scholar
Mur, M, Portella, MJ, Martínez-Arán, A, Pifarre, J, Vieta, E (2009). Influence of clinical and neuropsychological variables on the psychosocial and occupational outcome of remitted bipolar patients. Psychopathology 42, 148–156.Google Scholar
Mur, M, Portella, MJ, Martínez-Arán, A, Pifarré, J, Vieta, E (2008). Long-term stability of cognitive impairment in bipolar disorder: a 2-year follow-up study of lithium-treated euthymic bipolar patients. Journal of Clinical Psychiatry 69, 713–720.Google Scholar
Newman, SD, Greco, JA, Lee, D (2009). An fMRI study of the Tower of London: a look at problem structure differences. Brain Research 1286, 123–132.Google Scholar
Norbury, R, Selvaraj, S, Taylor, MJ, Harmer, C, Cowen, PJ (2010). Increased neural response to fear in patients recovered from depression: a 3T functional magnetic resonance imaging study. Psychological Medicine 40, 425–432.Google Scholar
Owen, AM (1997). Cognitive planning in humans: neuropsychological, neuroanatomical and neuropharmacological perspectives. Progress in Neurobiology 53, 431–450.Google Scholar
Paelecke-Habermann, Y, Pohl, J, Leplow, B (2005). Attention and executive functions in remitted major depression patients. Journal of Affective Disorders 89, 125–135.Google Scholar
Perlis, RH, Ostacher, MJ, Goldberg, JF, Miklowitz, DJ, Friedman, E, Calabrese, J, Thase, ME, Sachs, GS (2010). Transition to mania during treatment of bipolar depression. Neuropsychopharmacology 35, 2545–2552.Google Scholar
Pizzagalli, DA, Holmes, AJ, Dillon, DG, Goetz, EL, Birk, JL, Bogdan, R, Dougherty, DD, Iosifescu, DV, Rauch, SL, Fava, M (2009). Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder. American Journal of Psychiatry 166, 702–710.Google Scholar
Pompei, F, Dima, D, Rubia, K, Kumari, V, Frangou, S (2011). Dissociable functional connectivity changes during the Stroop task relating to risk, resilience and disease expression in bipolar disorder. NeuroImage 57, 576–582.Google Scholar
Porter, RJ, Gallagher, P, Thompson, JM, Young, AH (2003). Neurocognitive impairment in drug-free patients with major depressive disorder. British Journal of Psychiatry 182, 214–220.Google Scholar
Pu, S, Yamada, T, Yokoyama, K, Matsumura, H, Kobayashi, H, Sasaki, N, Mitani, H, Adachi, A, Kaneko, K, Nakagome, K (2011). A multi-channel near-infrared spectroscopy study of prefrontal cortex activation during working memory task in major depressive disorder. Neuroscience Research 70, 91–97.Google Scholar
Quraishi, S, Frangou, S (2002). Neuropsychology of bipolar disorder: a review. Journal of Affective Disorders 72, 209–226.Google Scholar
Rive, MM, Mocking, RJT, Koeter, MWJ, van Wingen, G, De Wit, S, Van den Heuvel, OA, Veltman, DJ, Ruhé, HG, Schene, AH (2015). State dependent differences in emotion regulation between unmedicated bipolar and major depressive disorder. JAMA Psychiatry 72, 687–696.Google Scholar
Rose, EJ, Simonotto, E, Spencer, EP, Ebmeier, KP (2006). The effects of escitalopram on working memory and brain activity in healthy adults during performance of the n-back task. Psychopharmacology 185, 339–347.Google Scholar
Ruh, N, Rahm, B, Unterrainer, JM, Weiller, C, Kaller, CP (2012). Dissociable stages of problem solving (II): first evidence for process-contingent temporal order of activation in dorsolateral prefrontal cortex. Brain and Cognition 80, 170–176.Google Scholar
Sachs, GS (2004). Strategies for improving treatment of bipolar disorder: integration of measurement and management. Acta Psychiatrica Scandinavica 10, S7–17.Google Scholar
Savitz, J, Solms, M, Ramesar, R (2005). Neuropsychological dysfunction in bipolar affective disorder: a critical opinion. Bipolar Disorders 7, 216–235.Google Scholar
Schlösser, RGM, Wagner, G, Koch, K, Dahnke, R, Reichenbach, JR, Sauer, H (2008). Fronto-cingulate effective connectivity in major depression: a study with fMRI and dynamic causal modeling. NeuroImage 43, 645–655.Google Scholar
Schmand, B, Bakker, D, Saan, R, Louman, J (1991). The dutch reading test for adults: a measure of premorbid intelligence level. Tijdschrift voor Gerontologie en Geriatrie 22, 15–19.Google Scholar
Shallice, T (1982). Specific impairments of planning. Philosophical Transactions of the Royal Society of London B: Biological Sciences 298, 199–209.Google Scholar
Sheline, YI (2003). Neuroimaging studies of mood disorder effects on the brain. Biological Psychiatry 54, 338–352.Google Scholar
Silverstone, PH, Bell, EC, Willson, MC, Dave, S, Wilman, AH (2005). Lithium alters brain activation in bipolar disorder in a task- and state-dependent manner: an fMRI study. Annals of General Psychiatry 4.Google Scholar
Smith, DJ, Muir, WJ, Blackwood, DH (2006). Neurocognitive impairment in euthymic young adults with bipolar spectrum disorder and recurrent major depressive disorder. Bipolar Disorders 8, 40–46.Google Scholar
Smith, EE, Jonides, J (1999). Storage and executive processes in the frontal lobes. Science 283, 1657–1662.Google Scholar
Smoski, MJ, Rittenberg, A, Dichter, GS (2011). Major depressive disorder is characterized by greater reward network activation to monetary than pleasant image rewards. Psychiatry Research 194, 263–270.Google Scholar
Snyder, HR (2013). Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review. Psychological Bulletin 139, 81–132.Google Scholar
Stefanopoulou, E, Manoharan, A, Landau, S, Geddes, JR, Goodwin, G, Frangou, S (2009). Cognitive functioning in patients with affective disorders and schizophrenia: a meta-analysis. International Review of Psychiatry 21, 336–356.Google Scholar
Stordal, KI, Lundervold, AJ, Egeland, J, Mykletun, A, Asbjørnsen, A, Landrø, NI, Roness, A, Rund, BR, Sundet, K, Oedegaard, KJ, Lund, A (2004). Impairment across executive functions in recurrent major depression. Nordic Journal of Psychiatry 58, 41–47.Google Scholar
Strakowski, SM, Adler, CM, Delbello, MP (2002). Volumetric MRI studies of mood disorders: do they distinguish unipolar and bipolar disorder? Bipolar Disorders 4, 80–88.Google Scholar
Strakowski, SM, Adler, CM, Holland, SK, Mills, N, DelBello, MP (2004). A preliminary FMRI study of sustained attention in euthymic, unmedicated bipolar disorder. Neuropsychopharmacology 29, 1734–1740.Google Scholar
Strakowski, SM, Adler, CM, Holland, SK, Mills, NP, DelBello, MP, Eliassen, JC (2005). Abnormal fMRI brain activation in euthymic bipolar disorder patients during a counting Stroop interference task. American Journal of Psychiatry 162, 1697–1705.Google Scholar
Sweeney, JA, Kmiec, JA, Kupfer, DJ (2000). Neuropsychologic impairments in bipolar and unipolar mood disorders on the CANTAB neurocognitive battery. Biological Psychiatry 48, 674–684.Google Scholar
Taylor Tavares, JV, Clark, L, Cannon, DM, Erickson, K, Drevets, WC, Sahakian, BJ (2007). Distinct profiles of neurocognitive function in unmedicated unipolar depression and bipolar II depression. Biological Psychiatry 62, 917–924.Google Scholar
Tiihonen, J, Haukka, J, Henriksson, M, Cannon, M, Kieseppä, T, Laaksonen, I, Sinivuo, J, Lönnqvist, J (2005). Premorbid intellectual functioning in bipolar disorder and schizophrenia: results from a cohort study of male conscripts. American Journal of Psychiatry 162, 1904–1910.Google Scholar
Unterrainer, J, Owen, A (2006). Planning and problem solving: from neuropsychology to functional neuroimaging. Journal of Physiology Paris 99, 308–317.Google Scholar
Van den Heuvel, OA, Groenewegen, HJ, Barkhof, F, Lazeron, RHC, van Dyck, R, Veltman, DJ (2003). Frontostriatal system in planning complexity: a parametric functional magnetic resonance version of tower of London task. NeuroImage 18, 367–374.Google Scholar
Van Tol, MJ, Van der Wee, NJA, Demenescu, LR, Nielen, MMA, Aleman, A, Renken, R, Van Buchem, MA, Zitman, FG, Veltman, DJ (2011). Functional MRI correlates of visuospatial planning in out-patient depression and anxiety. Acta Psychiatrica Scandinavica 124, 273–284.CrossRefGoogle ScholarPubMed
Völlm, B, Richardson, P, McKie, S, Elliott, R, Deakin, JFW, Anderson, IM (2006). Serotonergic modulation of neuronal responses to behavioural inhibition and reinforcing stimuli: an fMRI study in healthy volunteers. European Journal of Neuroscience 23, 552–560.Google Scholar
Wagner, G, Koch, K, Reichenbach, JR, Sauer, H, Schlösser, RGM (2006). The special involvement of the rostrolateral prefrontal cortex in planning abilities: an event-related fMRI study with the Tower of London paradigm. Neuropsychologia 44, 2337–2347.Google Scholar
Weiland-Fiedler, P, Erickson, K, Waldeck, T, Luckenbaugh, DA, Pike, D, Bonne, O, Charney, DS, Neumeister, A (2004). Evidence for continuing neuropsychological impairments in depression. Journal of Affective Disorders 82, 253–258.Google Scholar
Wekking, EM, Bockting, CLH, Koeter, MWJ, Schene, AH (2012). Cognitive functioning in euthymic recurrently depressed patients: relationship with future relapses and prior course of disease. Journal of Affective Disorders 141, 300–307.Google Scholar
Welander-Vatn, A, Jensen, J, Otnaess, MK, Agartz, I, Server, A, Melle, I, Andreassen, OA (2013). The neural correlates of cognitive control in bipolar I disorder: an fMRI study of medial frontal cortex activation during a Go/No-go task. Neuroscience Letters 549, 51–56.Google Scholar
Wessa, M, Houenou, J, Paillère-Martinot, M-L, Berthoz, S, Artiges, E, Leboyer, M, Martinot, J-L (2007). Fronto-striatal overactivation in euthymic bipolar patients during an emotional go/nogo task. American Journal of Psychiatry 164, 638–646.Google Scholar
Wingen, M, Kuypers, KPC, Van de Ven, V, Formisano, E, Ramaekers, JG (2008). Sustained attention and serotonin: a pharmaco-fMRI study. Human Psychopharmacology: Clinical and Experimental 23, 221–230.Google Scholar
Wolfe, J, Granholm, E, Butters, N, Saunders, E, Janowsky, D (1987). Verbal memory deficits associated with major affective disorders: a comparison of unipolar and bipolar patients. Journal of Affective Disorders 13, 83–92.CrossRefGoogle ScholarPubMed
Xu, G, Lin, K, Rao, D, Dang, Y, Ouyang, H, Guo, Y, Ma, J, Chen, J (2012). Neuropsychological performance in bipolar I, bipolar II and unipolar depression patients: a longitudinal, naturalistic study. Journal of Affective Disorders 136, 328–339.Google Scholar
Yatham, LN, Torres, IJ, Malhi, GS, Frangou, S, Glahn, DC, Bearden, CE, Burdick, KE, Martínez-Arán, A, Dittmann, S, Goldberg, JF, Ozerdem, A, Aydemir, O, Chengappa, KNR (2010). The international society for bipolar disorders-battery for assessment of neurocognition (ISBD-BANC). Bipolar Disorders 12, 351–363.Google Scholar
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