Hostname: page-component-848d4c4894-tn8tq Total loading time: 0 Render date: 2024-07-02T22:18:53.917Z Has data issue: false hasContentIssue false
  • English
  • Français

TRH by slow, continuous infusion: an antidepressant?

Published online by Cambridge University Press:  09 July 2009

W. Van Den Burg ,
H. M. Van Praag ,
E. R. H. Bos ,
D. A. Piers ,
A. K. Van Zanten  and
H. Doorenbos
W. Van Den Burg*
Affiliation:
Department of Biological Psychiatry, Department of Internal Medicine, Division of Endocrinology and Isotope Laboratory, University Hospital, Groningen, The Netherlands
H. M. Van Praag
Affiliation:
Department of Biological Psychiatry, Department of Internal Medicine, Division of Endocrinology and Isotope Laboratory, University Hospital, Groningen, The Netherlands
E. R. H. Bos
Affiliation:
Department of Biological Psychiatry, Department of Internal Medicine, Division of Endocrinology and Isotope Laboratory, University Hospital, Groningen, The Netherlands
D. A. Piers
Affiliation:
Department of Biological Psychiatry, Department of Internal Medicine, Division of Endocrinology and Isotope Laboratory, University Hospital, Groningen, The Netherlands
A. K. Van Zanten
Affiliation:
Department of Biological Psychiatry, Department of Internal Medicine, Division of Endocrinology and Isotope Laboratory, University Hospital, Groningen, The Netherlands
H. Doorenbos
Affiliation:
Department of Biological Psychiatry, Department of Internal Medicine, Division of Endocrinology and Isotope Laboratory, University Hospital, Groningen, The Netherlands
*
11Address for correspondence: Dr W. van den Burg, Department of Biological Psychiatry, Oostersingel 59, Groningen, The Netherlands.
Get access Rights & Permissions [Opens in a new window]

Synopsis

A slow, continuous infusion of 1000 μg TRH (thyrotropin releasing hormone) over a period of 4 h had a very faint and diffuse short-lasting beneficial effect on a group of 10 depressive patients. This was assessed in a double blind cross-over trial with placebo. The effect was of no therapeutic value. No difference was found between the depressive patients and a control group of normal subjects in TSH response, T3 resin uptake, T4 or free thyroxine index values as a consequence of the TRH infusion.

Type
Research Article
Information
Psychological Medicine , Volume 6 , Issue 3 , August 1976 , pp. 393 - 397
Copyright
Copyright © Cambridge University Press 1976

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Aitken, R. C. B. (1969). Measurement of feelings using visual analogue scales. Proceedings of the Royal Society of Medicine 62, 989–996.CrossRefGoogle ScholarPubMed
Burg, W. van den, Praag, H. M. van, Bos, E. R. H., Piers, D. A., Zanten, A. K. van & Doorenbos, H. (1975). TRH as a possible quick-acting, but short-lasting antidepressant. Psychological Medicine 5, 404–412.CrossRefGoogle ScholarPubMed
Coppen, A., Montgomery, S., Peet, M., Baily, J., Marks, V. & Woods, P. (1974). Thyrotropin-releasing hormone in the treatment of depression. Lancer ii, 433–435.CrossRefGoogle Scholar
Dixon, W. J. & Mood, A. M. (1946). The statistical sign test. American Statistical Association Journal, 41, 557–566. Reprinted in Statistical Issues: a Reader for the Behaviour Sciences, pp. 339–345. Edited by R. E. Kirk (1972), Wack-worth: Belmont, California.CrossRefGoogle ScholarPubMed
Hamilton, M. (1967). Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology 6, 278–296.CrossRefGoogle ScholarPubMed
Howorth, P. J. N. & MacLagan, N. F. (1969). Clinical application of serum total thyroxine estimation, resin-uptake, and free thyroxine index. Lancet i, 224–228.CrossRefGoogle Scholar
Kastin, A. J., Ehrensing, R. H., Schalch, D. S. & Anderson, M. S. (1972). Improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone. Lancet ii, 740–742.CrossRefGoogle Scholar
Kersen, F. van, Doorenbos, H., Waringa, B. H. & Woldring, M. G. (1972 a). Serum thyroxine after infusion of TRH, Clinica Chimica Acta 38, 239–241.CrossRefGoogle ScholarPubMed
Kersen, F. van, Sluiter, W. J., Wijnands, P. N. & Vaalburg, W. (1972 b). The advantages of a specific thyroxine assay in combination with a trijodothyroxine resinuptake test: the free thyroxine index. Folia Medica Neerlandia 15, 177–183.Google Scholar
Leppäluoto, J., Virkkunen, P. & Lybeck, H. (1972). Elimination of TRH in man. The Journal of Clinical Endocrinology and Metabolism 35, 477–478.CrossRefGoogle ScholarPubMed
Maggini, C., Guazzelli, M., Mauri, M., Carraca, S., Fornaro, P., Martino, E., Macchia, E. & Baschieri, L. (1974). Sleep, clinical and endocrine studies in depressive patients treated with thyrotropin releasing hormone.Presented to the Second European Congress on Sleep ResearchRomeApril 8–11, 1974.Google Scholar
Prange, A. J. Jr, Wilson, I. C., Lara, P. P., Alltop, L. B. & Breese, G. R. (1972). Effects of thyrotropin-releasing hormone in depression. Lancet ii, 999–1002.CrossRefGoogle Scholar
Proceedings of the 1974 Meeting of the Early Clinical Drug Evaluation Units (ECDEU), Psychopharmacology Research Brain NIMH (1975). Psychopharmacology Bulletin 11, 19–20.Google Scholar
Sluiter, W. J., Kersen, F. van, Zanten, A. K. van, Beekhuis, H. & Doorenbos, H. (1972). A radioimmunoassay of human TRH, employing a solid phase second antibody, and a purified globulin preparation for standardization of nonspecific protein interactions. Clinica Chimica Acta 42, 255–262.CrossRefGoogle Scholar
Takahashi, S., Kondo, H., Yoshima, M. & Ochi, Y. (1973). Antidepressant effect of thyrotropin-releasing hormone (TRH) and the plasma thyrotropin levels in depression. Folia Psychiatrica et Neurologica Japonica 27, 305–314.Google ScholarPubMed
Vis-Melsen, M. J. E. van der & Wiener, J. D. (1972). Improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone. Lancet ii, 1415.CrossRefGoogle Scholar
Wilber, J. F. (1971). Stimulation of 14C-glucosamine and 14C-alanine incorporation into thyrotrophin by synthetic thyrotropin-releasing hormone. Endocrinology 89, 873–877.CrossRefGoogle Scholar
Zeally, A. K. & Aitken, R. C. B. (1969). Measurement of mood. Proceedings of the Royal Society of Medicine 62, 993–996.CrossRefGoogle Scholar